血清HBV RNA组成动力学作为肝内HBV cccDNA转换的标志

StephenW

J Med Virol. 2020 Apr 22. doi: 10.1002/jmv.25925. [Epub ahead of print]
Serum HBV RNA Composition Dynamics as Marker for Intrahepatic HBV cccDNA Turnover.
Hong X1, Hu J1.
Author information

1
    Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.

Abstract

Current therapies can suppress the replication of hepatitis B virus (HBV) but cannot clear chronic HBV infection, which afflicts hundreds of millions worldwide. HBV persistence is sustained by the viral covalently closed circular DNA (cccDNA), an episome in the nucleus of infected hepatocytes. cccDNA is refractory to current therapies and its clearance is the holy grail for HBV cure. However, it has been difficult to monitor the fate of cccDNA in the liver directly. The current study takes a novel approach to this critical issue by monitoring the dynamic change in the genetic composition of the serum HBV RNA, which appears to reflect the dynamics of intrahepatic cccDNA turnover. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.
KEYWORDS:

Anti-hepatitis B virus antivirals; Antiviral agents; Hepatitis B virus; Infection; Nucleoside analog reverse transcriptase; Persistent infection; Virus classification

PMID:
    32320077
DOI:
    10.1002/jmv.25925

StephenW

J Med Virol。 2020年4月22日。doi：10.1002 / jmv.25925。 [Epub提前发行]
血清HBV RNA组成动力学作为肝内HBV cccDNA转换的标志。
洪X1，胡J1。
作者信息

1个
    宾夕法尼亚州立大学医学院微生物学和免疫学系，美国宾夕法尼亚州赫尔希。

抽象

当前的疗法可以抑制乙型肝炎病毒（HBV）的复制，但不能清除慢性HBV感染，这种感染困扰着全球数亿人。 HBV持久性由病毒共价闭合的环状DNA（cccDNA）维持，这是被感染肝细胞核中的一种附加体。 cccDNA对目前的治疗是难治的，其清除率是治愈HBV的圣杯。但是，很难直接监测肝脏中cccDNA的命运。本研究通过监测血清HBV RNA遗传组成的动态变化，采用了一种新颖的方法来解决这一关键问题，该动态变化似乎反映了肝内cccDNA转换的动态。本文受版权保护。版权所有。

本文受版权保护。版权所有。
关键字：

抗乙型肝炎病毒抗病毒药；抗病毒药；乙型肝炎病毒;感染;核苷类似物逆转录酶；持续感染；病毒分类

PMID：
    32320077
DOI：
    10.1002 / jmv.25925