停止抗病毒药物治疗后继发HBsAg丧失后，慢性乙型肝炎再激活

StephenW

[Acute exacerbation of reactivated chronic hepatitis-b after stopping antiviral medication followed by loss of HBsAg].
[Article in German; Abstract available in German from the publisher]
Bert F1, Rossol S1.
Author information

1
    Department of internal medicine, Krankenhaus Nordwest, Frankfurt/Main, Germany.

Abstractin English, German
HISTORY AND CLINICAL FINDINGS:

 A 66-year-old women with chronic hepatitis-b and antiviral therapy was presented with icterus and sickness 2 weeks after cold symptoms. The treatment was stopped by patient 6 month before. The liver was enlarged, the abdomen and further body status unsuspicious.
FINDINGS AND DIAGNOSIS:

 The chemical results showed elevated liver enzymes and bilirubin values. The hepatitis-b status revealed signs of chronical course (HBsAg positive), the virus amount was > 21 Mio IU/ml. The sonographic abdominal status was normal.
THERAPY AND COURSE:

 The antiviral therapy was re-established and liver enzymes improved. The virus amount was falling and after 22 weeks antiviral therapy seroconversion (HBsAg negative) and healing up of hepatitis-b was objectified.
CONCLUSION:

 Acute exacerbation of chronic hepatitis-b followed stopping antiviral treatment can lead to healing by loss of HBsAg.

© Georg Thieme Verlag KG Stuttgart · New York.

PMID:
    32294781
DOI:
    10.1055/a-1120-3930

StephenW

停止抗病毒药物治疗后继发HBsAg丧失后，慢性乙型肝炎再激活急性加重。
[德语文章；可从出版商获得德语摘要]
伯特F1，罗索尔S1。
作者信息

1个
    德国美因河畔法兰克福西北医院Krankenhaus，内科。

摘要英文，德文
历史和临床发现：

一名患有慢性b型肝炎和抗病毒治疗的66岁妇女在感冒症状出现后2周出现黄疸和疾病。患者在6个月前停止治疗。肝脏肿大，腹部和进一步的身体状况令人怀疑。
结果和诊断：

化学结果显示肝酶和胆红素值升高。乙型肝炎显示出慢性病程的迹象（HBsAg阳性），病毒量> 21 Mio IU / ml。腹部超声检查正常。
治疗和课程：

重新建立了抗病毒疗法，改善了肝酶。病毒数量下降，经过22周的抗病毒治疗血清转化（HBsAg阴性）和b型肝炎的治愈是客观的。
结论：

停止抗病毒治疗后，慢性乙型肝炎的急性加重可导致HBsAg丢失而导致治愈。

©Georg Thieme Verlag KG斯图加特·纽约。

PMID：
    32294781
DOI：
    10.1055 / a-1120-3930