协助肝炎携带者夫妇繁殖。

StephenW

Best Pract Res Clin Obstet Gynaecol. 2020 Mar 7. pii: S1521-6934(20)30041-9. doi: 10.1016/j.bpobgyn.2020.02.013. [Epub ahead of print]
Assisted reproduction in hepatitis carrier couples.
Mak JSM1, Lao TT2.
Author information

1
    Assisted Reproduction Technology Unit, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong. Electronic address: [email protected].
2
    Department of Obstetrics & Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong. Electronic address: [email protected].

Abstract

Chronic Hepatitis B virus (HBV) infection is endemic worldwide, and the prevalence is especially high in the Asia-Pacific regions. Despite its high prevalence, the literature regarding the impact of HBV infection on subfertility and fertility treatment remains limited and conflicting. Latest studies do not suggest any detrimental effect of HBV infection on the outcome of IVF/ICSI treatment in women having chronic HBV infection. There is evidence that HBV exists in ovarian tissue including oocyte and follicular fluid, and therefore has the potential risk of transmission to the embryo, which can explain the finding of vertical transmission despite immunoprophylaxis. Most recently, we have observed the evidence of HBV viral replication in female HBV carriers undergoing IVF/ICSI treatment. This raises the question of whether antiviral medication should be administered during ovarian stimulation in IVF/ICSI treatment cycles for women with chronic HBV infection to help reduce the chance of vertical transmission.

Copyright © 2020. Published by Elsevier Ltd.
KEYWORDS:

Follicular fluid; Hepatitis B virus Infection; In vitro fertilization; Vertical transmission; Virus replication

PMID:
    32278628
DOI:
    10.1016/j.bpobgyn.2020.02.013

StephenW

最佳实践研究临床妇产科。 2020年3月7日。pii：S1521-6934（20）30041-9。 Doi：10.1016 / j.bpobgyn.2020.02.013。 [Epub提前发行]
协助肝炎携带者夫妇繁殖。
Mak JSM1，老挝TT2。
作者信息

1个
香港中文大学，威尔斯亲王医院，辅助生殖技术科，香港沙田。电子地址：[email protected]。
2
香港中文大学，香港沙田，威尔斯亲王医院妇产科。电子地址：[email protected]。

抽象

慢性乙型肝炎病毒（HBV）感染是世界范围内的流行病，在亚太地区的患病率尤其高。尽管HBV感染率很高，但有关HBV感染对不育和不育治疗的影响的文献仍然有限且相互矛盾。最新研究表明，对于患有慢性HBV感染的妇女，HBV感染对IVF / ICSI治疗的结果没有任何有害影响。有证据表明，HBV存在于包括卵母细胞和卵泡液的卵巢组织中，因此具有传播至胚胎的潜在风险，这可以解释尽管进行了免疫预防也发现了垂直传播。最近，我们观察到接受IVF / ICSI治疗的女性HBV携带者中HBV病毒复制的证据。这就提出了一个问题，对于患有慢性HBV感染的女性，在IVF / ICSI治疗周期的卵巢刺激过程中是否应使用抗病毒药物，以帮助减少静脉传播的机会。

版权所有©2020。由Elsevier Ltd.发布。
关键字：

卵泡液乙型肝炎病毒感染；体外受精；垂直传输；病毒复制

PMID：
32278628
DOI：
10.1016 / j.bpobgyn.2020.02.013

StephenW

https://www.sciencedirect.com/sc ... 20300419?via%3Dihub