酒精在乙型肝炎病毒感染的发病机理中的作用。

StephenW

World J Gastroenterol. 2020 Mar 7;26(9):883-903. doi: 10.3748/wjg.v26.i9.883.
Role of alcohol in pathogenesis of hepatitis B virus infection.
Ganesan M1, Eikenberry A1, Poluektova LY2, Kharbanda KK1, Osna NA1.
Author information

1
    Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, United States.
2
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, United States.

Abstract

Hepatitis B virus (HBV) and alcohol abuse often contribute to the development of end-stage liver disease. Alcohol abuse not only causes rapid progression of liver disease in HBV infected patients but also allows HBV to persist chronically. Importantly, the mechanism by which alcohol promotes the progression of HBV-associated liver disease are not completely understood. Potential mechanisms include a suppressed immune response, oxidative stress, endoplasmic reticulum and Golgi apparatus stresses, and increased HBV replication. Certainly, more research is necessary to gain a better understanding of these mechanisms such that treatment(s) to prevent rapid liver disease progression in alcohol-abusing HBV patients could be developed. In this review, we discuss the aforementioned factors for the higher risk of liver diseases in alcohol-induced HBV pathogenies and suggest the areas for future studies in this field.

©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
KEYWORDS:

Alcohol; Hepatitis B virus; Immunity; Liver disease; Oxidative stress

PMID:
    32206001
PMCID:
    PMC7081008
DOI:
    10.3748/wjg.v26.i9.883

Free PMC Article

StephenW

世界J胃肠病学杂志。 2020年3月7日； 26（9）：883-903。 Doi：10.3748 / wjg.v26.i9.883。
酒精在乙型肝炎病毒感染的发病机理中的作用。
Ganesan M1，Eikenberry A1，Poluektova LY2，Kharbanda KK1，Osna NA1。
作者信息

1个
内布拉斯加州西部爱荷华州医疗体系退伍军人事务研究服务局，美国内华达州68105。
2
内布拉斯加州大学医学中心药理学和实验神经科学系，美国内布拉斯加州68198。

抽象

乙型肝炎病毒（HBV）和酒精滥用通常会导致晚期肝病的发展。酗酒不仅会导致HBV感染患者快速发展肝病，而且会使HBV长期持续存在。重要的是，酒精促进HBV相关肝病发展的机制尚未完全了解。潜在的机制包括抑制的免疫反应，氧化应激，内质网和高尔基体应激以及增加的HBV复制。当然，需要更多的研究来更好地理解这些机制，从而可以开发出预防滥用酒精的HBV患者迅速发展肝病的治疗方法。在这篇综述中，我们讨论了上述因素在酒精引起的HBV病原体中引起肝脏疾病的风险较高，并为该领域的未来研究提供了建议。

©作者2020。由百世登出版集团有限公司出版。保留所有权利。
关键字：

醇;乙型肝炎病毒;免疫;肝病;氧化应激

PMID：
32206001
PMCID：
PMC7081008
DOI：
10.3748 / wjg.v26.i9.883

免费PMC文章

StephenW

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081008/