白蛋白与碱性磷酸酶的比率与乙型肝炎病毒阳性肝癌患者的

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Albumin-to-Alkaline Phosphatase Ratio Associates with Good Prognosis of Hepatitis B Virus-Positive HCC Patients
         

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Authors Li Q, Lyu Z, Wang L, Li F, Yang Z, Ren W

Received 12 December 2019

Accepted for publication 26 February 2020

Published 20 March 2020 Volume 2020:13 Pages 2377—2384

DOI https://doi.org/10.2147/OTT.S242034

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Prof. Dr. Takuya Aoki

Qun Li,1,* Zhuozhen Lyu,1,* Liguang Wang,2,* Feifei Li,1 Zhen Yang,1 Wanhua Ren1

1Department of Infectious Disease, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, People’s Republic of China; 2Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Wanhua Ren
Department of Infectious Disease, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, People’s Republic of China
Email [email protected]

Purpose: The aim of this study was to investigate the prognostic significance of preoperative AAPR in hepatitis B virus-related hepatocellular carcinoma patients after curative hepatectomy.
Patients and Methods: A total of 221 patients with hepatitis B virus-related HCC patients who received curative liver resection were included. After propensity matching analysis, 188 patients were enrolled in the final analysis. COX regression analyses were used to analyze the prognosis value of AAPR and other prognostic factors. The overall survival (OS) and recurrence-free survival (RFS) curves were constructed and compared between different groups.
Results: The optimal cutoff of AAPR was defined as 0.40 with X-tile software. According to cutoff value, patients were divided into low-AAPR group (≤ 0.40) and high-AAPR group (> 0.40). The cumulative 1-, 3-, and 5-year OS rates were 97.1%, 78.2%, and 67.3% in patients with AAPR> 0.40 group, respectively, which were significantly higher than those in the AAPR≤ 0.40 group (80.2%, 54.4%, and 40.1%, respectively) (P < 0.001). In the multivariate COX regression analysis, AAPR, tumor number, ascites, and portal vein tumor thrombus (PVTT) were independent risk factors for OS and RFS.
Conclusion: AAPR shows promise as a reliable prognostic factor in patients with hepatitis B virus-related HCC after curative hepatectomy, which could be used as a routine inspection of HCC patients before surgery.

Keywords: albumin-to-alkaline phosphatase ratio, prognosis, hepatitis B virus, hepatocellular carcinoma

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白蛋白与碱性磷酸酶的比率与乙型肝炎病毒阳性肝癌患者的良好预后相关


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作者李Q，吕Z，王L，李F，杨Z，任W

2019年12月12日收到

2020年2月26日接受发布

2020年3月20日发布2020卷：13页2377-2384

DOI https://doi.org/10.2147/OTT.S242034

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批准发表的编辑：青木卓ya教授

李群1，*卓振L，1，*王立光2、2，*飞飞李，杨振1，万华1

1山东大学附属省立医院传染病科，山东济南250021； 2山东第一医科大学附属山东省立医院肿瘤科，山东大学附属山东省立医院，山东济南250021

* 这些作者同等贡献这项工作

通讯：任万华
山东大学附属山东省立医院传染病科，山东济南250021
电子邮件[email protected]

目的：本研究旨在探讨根治性肝切除术后乙型肝炎病毒相关肝细胞癌患者术前AAPR的预后意义。
患者与方法：纳入221例接受根治性肝切除的乙型肝炎病毒相关HCC患者。经过倾向匹配分析后，有188例患者参加了最终分析。使用COX回归分析分析AAPR的预后价值和其他预后因素。构建了总生存期（OS）和无复发生存期（RFS）曲线，并在不同组之间进行了比较。
结果：使用X-tile软件将AAPR的最佳临界值定义为0.40。根据临界值将患者分为低AAPR组（≤0.40）和高AAPR组（> 0.40）。 AAPR> 0.40组的患者的1年，3年和5年OS累积累积率分别为97.1％，78.2％和67.3％，显着高于AAPR≤0.40组（80.2％，分别为54.4％和40.1％）（P <0.001）。在多元COX回归分析中，AAPR，肿瘤数目，腹水和门静脉肿瘤血栓（PVTT）是OS和RFS的独立危险因素。
结论：AAPR有望将其作为治愈性肝切除术后乙型肝炎病毒相关性HCC患者的可靠预后因素，可作为术前对HCC患者的常规检查。

关键词：白蛋白与碱性磷酸酶比值，预后，乙型肝炎病毒，肝细胞癌

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