慢性乙型肝炎病毒感染的表观遗传调控。

StephenW

Semin Immunopathol. 2020 Mar 17. doi: 10.1007/s00281-020-00780-6. [Epub ahead of print]
Epigenetic modulation in chronic hepatitis B virus infection.
Dandri M1,2.
Author information

1
    I. Department of Internal Medicine, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. [email protected].
2
    German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, Hamburg, Germany. [email protected].

Abstract

The human hepatitis B virus (HBV) is a small-enveloped DNA virus causing acute and chronic hepatitis. Despite the existence of an effective prophylactic vaccine and the strong capacity of approved antiviral drugs to suppress viral replication, chronic HBV infection (CHB) continues to be a major health burden worldwide. Both the inability of the immune system to resolve CHB and the unique replication strategy employed by HBV, which forms a stable viral covalently closed circular DNA (cccDNA) minichromosome in the hepatocyte nucleus, enable infection persistence. Knowledge of the complex network of interactions that HBV engages with its host is still limited but accumulating evidence indicates that epigenetic modifications occurring both on the cccDNA and on the host genome in the course of infection are essential to modulate viral activity and likely contribute to pathogenesis and cancer development. Thus, a deeper understanding of epigenetic regulatory processes may open new venues to control and eventually cure CHB. This review summarizes major findings in HBV epigenetic research, focusing on the epigenetic mechanisms regulating cccDNA activity and the modifications determined in infected host cells and tumor liver tissues.
KEYWORDS:

HBV; HBx; Interferon; Minichromosome; cccDNA

PMID:
    32185454
DOI:
    10.1007/s00281-020-00780-6

StephenW

赛明免疫病。 2020年3月17日。doi：10.1007 / s00281-020-00780-6。 [Epub提前发行]
慢性乙型肝炎病毒感染的表观遗传调控。
丹德里M1,2。
作者信息

1个
    I.汉堡-埃彭多夫大学医学中心内科中心内科中心，马丁内斯。 52，20246，德国汉堡。 [email protected]。
2
    德国感染研究中心（DZIF），德国汉堡-吕贝克-伯斯特尔-里姆斯基地。 [email protected]。

抽象

人乙型肝炎病毒（HBV）是一种小包膜DNA病毒，可引起急性和慢性肝炎。尽管存在有效的预防性疫苗，并且已获批准的抗病毒药物具有抑制病毒复制的强大能力，但慢性HBV感染（CHB）仍然是全球范围内的主要健康负担。免疫系统无法分辨CHB和HBV所采用的独特复制策略（在肝细胞核中形成稳定的病毒共价闭合环状DNA（cccDNA）微染色体）均使感染持续存在。乙肝病毒与其宿主相互作用的复杂相互作用网络的知识仍然有限，但是越来越多的证据表明，在感染过程中，在cccDNA和宿主基因组上发生的表观遗传修饰对于调节病毒活性是必不可少的，并且可能有助于发病和癌症发展。因此，对表观遗传调控过程的更深入了解可能会为控制和最终治愈CHB开辟新的场所。这篇综述总结了HBV表观遗传学研究的主要发现，着重于调控cccDNA活性的表观遗传机制以及在感染的宿主细胞和肿瘤肝组织中确定的修饰。
关键字：

乙肝病毒HBx;干扰素微染色体基因

PMID：
    32185454
DOI：
    10.1007 / s00281-020-00780-6

StephenW

https://link.springer.com/conten ... 281-020-00780-6.pdf

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