HBV与肝细胞先天免疫之间的相互作用

StephenW

Viruses. 2020 Mar 5;12(3). pii: E285. doi: 10.3390/v12030285.
The Interactions between HBV and the Innate Immunity of Hepatocytes.
Megahed FAK1,2, Zhou X1, Sun P1.
Author information

1
    Stem Cell Research Center, Research Center for Reproductive Medicine, Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou 515041, China.
2
    Department of Nucleic Acid Researches, Genetic Engineering and Biotechnology Research Institute, General Autority- City of Scientific Researches and Technological Applications, Alexandria 21934, Egypt.

Abstract

Hepatitis B virus (HBV) infection affects ~350 million people and poses a major public health problem worldwide. HBV is a major cause of cirrhosis and hepatocellular carcinoma. Fewer than 5% of HBV-infected adults (but up to 90% of HBV-infected infants and children) develop chronic HBV infection as indicated by continued, detectable expression of hepatitis B surface antigen (HBsAg) for at least 6 months after the initial infection. Increasing evidence indicates that HBV interacts with innate immunity signaling pathways of hepatocytes to suppress innate immunity. However, it is still not clear how HBV avoids monitoring by the innate immunity of hepatocytes and whether the innate immunity of hepatocytes can be effective against HBV if re-triggered. Moreover, a deep understanding of virus-host interactions is important in developing new therapeutic strategies for the treatment of HBV infection. In this review, we summarize the current knowledge regarding how HBV represses innate immune recognition, as well as recent progress with respect to in vitro models for studying HBV infection and innate immunity.
KEYWORDS:

HBV; hepatocytes; in-vitro cell models; innate immunity

PMID:
    32151000
DOI:
    10.3390/v12030285

StephenW

病毒。 2020年3月5日； 12（3）。 pii：E285。 doi：10.3390 / v12030285。
HBV与肝细胞先天免疫之间的相互作用。
Megahed FAK1,2，周X1，孙P1。
作者信息

1个
    汕头大学医学院广东省传染病与分子免疫病理学重点实验室，生殖医学研究中心干细胞研究中心，广东汕头515041。
2
    通用技术研究与技术应用之城，基因工程与生物技术研究所核酸研究系，埃及亚历山大21934。

抽象

乙型肝炎病毒（HBV）感染影响了约3.5亿人，并在全球范围内构成了主要的公共卫生问题。乙肝病毒是肝硬化和肝细胞癌的主要原因。初次感染后至少6个月内可检测到的乙型肝炎表面抗原持续表达可表明，少于5％的HBV感染成人（但高达90％的HBV感染婴儿和儿童）发展为慢性HBV感染。感染。越来越多的证据表明，HBV与肝细胞的先天免疫信号通路相互作用，以抑制先天免疫。然而，尚不清楚HBV如何避免通过肝细胞的先天免疫力进行监测，以及如果再次触发，肝细胞的先天免疫力是否能有效抵抗HBV。此外，对病毒-宿主相互作用的深入了解对于开发用于治疗HBV感染的新治疗策略非常重要。在这篇综述中，我们总结了有关HBV如何抑制先天免疫识别的当前知识，以及有关研究HBV感染和先天免疫的体外模型的最新进展。
关键字：

乙肝病毒肝细胞体外细胞模型；先天免疫

PMID：
    32151000
DOI：
    10.3390 / v12030285

StephenW

https://www.mdpi.com/1999-4915/12/3/285/pdf