北美慢性乙型肝炎感染者的烟酒和咖啡消费量及肝病严重程

StephenW

Ann Hepatol. 2020 Feb 8. pii: S1665-2681(20)30009-0. doi: 10.1016/j.aohep.2020.01.005. [Epub ahead of print]
Alcohol, tobacco and coffee consumption and liver disease severity among individuals with Chronic Hepatitis B infection in North America.
Brahmania M1, Liu S2, Wahed AS3, Yim C1, Hansen BE4, Khalili M5, Terrault NA5, Lok AS6, Ghany M7, Wang J2, Wong D1, Janssen HLA8; Hepatitis B Research Network.
Author information

1
    Division of Gastroenterology, Toronto General Hospital, University Health Network, Toronto, Canada.
2
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, United States.
3
    Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, United States.
4
    Division of Gastroenterology, Toronto General Hospital, University Health Network, Toronto, Canada; IHPME, University of Toronto, Toronto, Canada.
5
    Division of Gastroenterology and Hepatology, University of California-San Francisco, San Francisco, CA, United States.
6
    Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, United States.
7
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
8
    Division of Gastroenterology, Toronto General Hospital, University Health Network, Toronto, Canada. Electronic address: [email protected].

Abstract
INTRODUCTION AND OBJECTIVES:

The prevalence of alcohol, tobacco, and coffee use and association with liver health among North Americans with Chronic Hepatitis B (CHB) infection has not been well described.
MATERIALS AND METHODS:

The Hepatitis B Research Network includes an observational study of untreated CHB adults enrolled at 21 sites in the United States and Canada. Alcohol use was categorized as none, moderate, and at-risk based on the definition from the National Institute on Alcohol Abuse and Alcoholism; tobacco use as never, current and former; coffee use as none, 1-2 cups/day, and ≥3 cups/day. Linear regression and linear mixed models were used to associate lifestyle behaviors with ALT and FIB-4 values.
RESULTS:

1330 participants met eligibility: 53% males, 71% Asian and the median age was 42 years (IQR: 34-52). Median ALT was 33U/L (IQR: 22-50), 37% had HBV DNA <103IU/mL, 71% were HBeAg negative, and 65% had a FIB-4 <1.45. At baseline, 8% of participants were at-risk alcohol drinkers, 11% were current smokers and 92% drank <3 cups of coffee/day. Current tobacco and 'at-risk' alcohol use, were significantly associated with elevated ALT levels in univariable analyses, however, these associations were not statistically significant when controlling for sociodemographic and HBV characteristics.
CONCLUSIONS:

In this large diverse cohort of untreated CHB participants, at-risk alcohol use, current tobacco use and limited coffee consumption did not have an association with high ALT and FIB-4 values. In contrast, significant associations were found between the frequency of these lifestyle behaviors and sociodemographic factors.

Copyright © 2020 Fundación Clínica Médica Sur, A.C. Published by Elsevier España, S.L.U. All rights reserved.
KEYWORDS:

Alcohol; Chronic Hepatitis B; Coffee; Hepatitis B Research Network; Tobacco

PMID:
    32139262
DOI:
    10.1016/j.aohep.2020.01.005

StephenW

安·赫帕托尔。 2020年2月8日。pii：S1665-2681（20）30009-0。 doi：10.1016 / j.aohep.2020.01.005。 [Epub提前发行]
北美慢性乙型肝炎感染者的烟酒和咖啡消费量及肝病严重程度。
Brahmania M1，Liu S2，Wahed AS3，Yim C1，Hansen BE4，Khalili M5，Terrault NA5，Lok AS6，Ghany M7，Wang J2，Wong D1，Janssen HLA8;乙肝研究网络。
作者信息

1个
    加拿大多伦多大学健康网络多伦多总医院消化内科。
2
    美国宾夕法尼亚州匹兹堡，匹兹堡大学流行病学系。
3
    美国宾夕法尼亚州匹兹堡，匹兹堡大学生物统计学系。
4
    加拿大多伦多大学健康网络多伦多总医院消化内科； IHPME，多伦多大学，加拿大多伦多。
5
    加利福尼亚大学旧金山分校胃肠病学和肝病学系，美国加利福尼亚。
6
    美国密西根州安阿伯市，密歇根大学胃肠病学和肝病学系。
7
    美国马里兰州贝塞斯达市国立卫生研究院国立糖尿病，消化与肾脏疾病研究所肝病科。
8
    加拿大多伦多大学健康网络多伦多总医院消化内科。电子地址：[email protected]。

抽象
简介和目标：

尚未充分描述北美慢性乙型肝炎（CHB）感染者中酒精，烟草和咖啡的使用率及其与肝脏健康的关系。
材料和方法：

乙型肝炎研究网络包括一项在美国和加拿大的21个站点进行的未经治疗的CHB成人的观察性研究。根据国家酒精滥用和酒精中毒研究所的定义，酒精的使用分为无，中度和有风险。当前和以前从未使用过烟草；不使用咖啡，每天1-2杯和≥3杯/天。使用线性回归和线性混合模型将生活方式行为与ALT和FIB-4值相关联。
结果：

符合资格的1330名参与者：男性53％，亚洲71％，中位年龄为42岁（IQR：34-52）。 ALT中位数为33U / L（IQR：22-50），HBV DNA <103IU / mL为37％，HBeAg阴性为71％，FIB-4 <1.45为65％。在基线时，有8％的参与者是高危饮酒者，有11％是经常吸烟者，有92％的人每天喝少于3杯咖啡。在单变量分析中，当前使用烟草和“高风险”酒精与ALT水平升高显着相关，但是，在控制社会人口统计学和HBV特征时，这些相关性在统计学上并不显着。
结论：

在未经治疗的CHB参与者这一庞大的队列中，高危饮酒，当前吸烟和有限的咖啡消费与高ALT和FIB-4值无关。相反，在这些生活方式的频率与社会人口统计学因素之间发现了显着的关联。

版权所有©2020FundaciónClínicaMédicaSur，A.C.由ElsevierEspaña，S.L.U发布。版权所有。
关键字：

醇;慢性乙型肝炎；咖啡;乙肝研究网络；烟草

PMID：
    32139262
DOI：
    10.1016 / j.aohep.2020.01.005

StephenW

https://www.sciencedirect.com/sc ... 20300090?via%3Dihub