血清标志物的动态变化及其在乙型肝炎相关肝细胞癌所有阶

StephenW

Onco Targets Ther. 2020 Jan 28;13:827-840. doi: 10.2147/OTT.S229835. eCollection 2020.
Dynamic Changes in Serum Markers and Their Utility in the Early Diagnosis of All Stages of Hepatitis B-Associated Hepatocellular Carcinoma.
Wu M1, Liu Z1, Li X1, Zhang A2, Li N1,2.
Author information

1
    Department of General Surgery, Beijing Youan Hospital, Capital Medical University, Beijing, People's Republic of China.
2
    Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, People's Republic of China.

Abstract
Objective:

This study aimed to evaluate the individual and combined diagnostic values of serum alpha-fetoprotein (AFP), des-gamma-carboxyprothrombin (DCP), glypican-3 (GPC3) and golgi protein 73 (GP73) in diagnosing hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).
Methods:

Participants from Beijing YouAn Hospital were enrolled and divided into seven groups. Serum was collected and the levels of AFP, GPC3, GP73 and DCP were simultaneously measured with a protein array. Pearson's χ2 test was applied to compare the clinicopathological characteristics. Receiver operating characteristic (ROC) curves were used to analyse the diagnostic performance of the four markers.
Results:

As a single biomarker for differentiating HCC from all controls, AFP had a larger area under the curve (AUC) (0.798, 95% CI (0.754-0.838) than the other biomarkers, with a sensitivity of 77.3% and a specificity of 71.1%. Among the other combinations, AFP plus GPC3 and DCP (0.871, 95% CI (0.833-0.903)) was the best at differentiating HCC from all controls. In discriminating very early stage and early stage HCC from all controls, the AUC of GPC3 (0.744, 95% CI (0.690-0.793); sensitivity 62.8%; specificity 83.3%) was better than that of AFP (0.723, 95% CI (0.668-0.774); sensitivity 67.3%; specificity 71.7%). Among all biomarker combinations, the combination of AFP, GPC3 and GP73 had the largest AUC (0.843, 95% CI (0.796-0.883); sensitivity 84.1%; specificity 71.7%). AFP (AUC 0.726, 95% CI (0.662-0.784)) showed the best performance in the very early diagnosis of HBV-related HCC.
Conclusion:

As a single biomarker, AFP has an advantage in the very early and early diagnosis of HBV-related HCC. The combination of AFP, GPC3 and GP73 is the most suitable marker for the early diagnosis of HBV-related HCC. However, AFP remains the best biomarker for the very early diagnosis of HBV-related HCC, and the adding of one or more markers does not significantly improve the diagnostic accuracy.

© 2020 Wu et al.
KEYWORDS:

diagnosis; hepatitis B virus; hepatocellular carcinoma; protein array

PMID:
    32095079
PMCID:
    PMC6995291
DOI:
    10.2147/OTT.S229835

StephenW

Onco瞄准目标。 2020年1月28日； 13：827-840。 doi：10.2147 / OTT.S229835。 eCollection 2020。
血清标志物的动态变化及其在乙型肝炎相关肝细胞癌所有阶段的早期诊断中的作用。
吴M1，刘Z1，李X1，张A2，李N1,2。
作者信息

1个
    首都医科大学附属北京佑安医院普外科，北京。
2
    首都医科大学附属北京佑安医院北京肝病研究所，中华人民共和国北京。

抽象
目的：

这项研究旨在评估血清α-甲胎蛋白（AFP），des-γ-羧基凝血酶原（DCP），glypican-3（GPC3）和高尔基蛋白73（GP73）在诊断乙型肝炎病毒（HBV）中的个别和综合诊断价值相关的肝细胞癌（HCC）。
方法：

来自北京佑安医院的参与者被分为七个组。收集血清，并用蛋白质阵列同时测量AFP，GPC3，GP73和DCP的水平。应用皮尔逊氏χ2检验比较临床病理特征。接收器工作特性（ROC）曲线用于分析这四个标记物的诊断性能。
结果：

作为将HCC与所有对照区分开的单一生物标志物，AFP的曲线下面积（AUC）（0.798，95％CI（0.754-0.838））比其他生物标志物大，敏感性为77.3％，特异性为71.1％ 。在其他组合中，AFP加GPC3和DCP（0.871，95％CI（0.833-0.903））是区分所有对照中HCC的最佳方法。在区分所有对照的早期和早期HCC时，GPC3的AUC （0.744，95％CI（0.690-0.793）;敏感性62.8％;特异性83.3％）优于AFP（0.723，95％CI（0.668-0.774）;敏感性67.3％;特异性71.7％）。组合中，AFP，GPC3和GP73的组合具有最大的AUC（0.843，95％CI（0.796-0.883）;敏感性84.1％;特异性71.7％）。AFP（AUC 0.726，95％CI（0.662-0.784））显示在HBV相关HCC的早期诊断中表现最佳。
结论：

作为单一生物标志物，AFP在早期和早期诊断HBV相关HCC方面具有优势。 AFP，GPC3和GP73的组合是最适合早期诊断HBV相关HCC的标志物。但是，AFP仍然是早期诊断HBV相关HCC的最佳生物标志物，添加一种或多种标志物并不能显着提高诊断准确性。

©2020 Wu等。
关键字：

诊断;乙型肝炎病毒；肝细胞癌；蛋白质阵列

PMID：
    32095079
PMCID：
    PMC6995291
DOI：
    10.2147 / OTT.S229835

StephenW

https://www.dovepress.com/getfile.php?fileID=55681