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J Viral Hepat. 2020 Feb 12. doi: 10.1111/jvh.13272. [Epub ahead of print]
Serum hepatitis B virus rna predicts response to peginterferon treatment in HBeAg-positive chronic hepatitis B.
van Campenhout MJH1, van Bömmel F2, Pfefferkorn M2, Fischer J2, Deichsel D2, Boonstra A1, van Vuuren AJ1, Berg T2, Hansen BE1,3,4, Janssen HLA1,4.
Author information
1
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
2
University Hospital Leipzig, Department of Gastroenterology and Rheumatology, Section of Hepatology, Leipzig, Germany.
3
Institute of Health Policy, Management and Evaluation, University of Toronto.
4
Toronto Center for Liver Disease, Toronto Western and General Hospital, University Health Network, Toronto, Canada.
Abstract
Hepatitis B virus (HBV) RNA in serum is a novel biomarker that reflectscccDNA activity. We investigated whether HBV RNA can predict serological response to peginterferon (PEG-IFN) treatment.Serum HBV RNA levels were retrospectively measured at weeks 0, 12, 24, and 52 of therapy and after treatment discontinuation (week 78) in 266 HBeAg-positive chronic HBV patients who had participated in a global randomized controlled trial (HBV99-01 study). Patients received 52 weeks PEG-IFN monotherapy (n=136) orPEG-IFN and lamivudine (n=130). The primary endpoint was HBeAg loss 24 weeks after PEG-IFN discontinuation. At baseline, the mean serum level of HBV RNA was 6.8 (SD 1.2) log c/mL. HBV RNA levels declined to 4.7 (1.7) log c/mL after one year of PEG-IFN therapy alone and to 3.3 (1.2)log c/mL after combination therapy. From week 12 onward, HBV RNA level was significantly lower in patients who achieved HBeAg loss at the end of follow-up as compared to those who did not, regardless of treatment allocation (week 12: 4.4 vs. 5.1 log c/mL, p=0.01; week 24: 3.7 vs. 4.9 log c/mL, p<0.001). The performance of a multivariable model based on HBV RNA level was comparable at week 12 (AUC 0.68)and 24 (AUC 0.72) of therapy. HBV RNA level above 5.5 log c/mL at week 12 showed negative predictive values of 93/67/90/64% for HBV genotypes A/B/C/D for the prediction of HBeAg loss. In conclusion, HBV RNA in serum declines profoundly during PEG-IFN treatment. Early on-treatment HBV RNA level may be used to predict non-response.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Chronic hepatitis B infection; Functional cure; Peginterferon treatment; Serum marker; Treatment response
PMID:
32052503
DOI:
10.1111/jvh.13272
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