IFN-γ信号通路中的单核苷酸多态性与中国儿童乙型肝炎病毒

StephenW

Can J Infect Dis Med Microbiol. 2020 Jan 22;2020:8121659. doi: 10.1155/2020/8121659. eCollection 2020.
Single Nucleotide Polymorphisms in IFN-γ Signaling Pathway Associated with Risk of Hepatitis B Virus Infection in Chinese Children.
Zhuo Y1, Yang Y1, Zhang M2, Xu Y1, Chen Z2, Mu L1, Tang X1, Zhong Z1, Chen J3, Zhou L1.
Author information

1
    Department of Epidemiology, School of Public Health and Management, Chongqing Medical University, Chongqing, China.
2
    The People's Hospital of Jiulongpo District, Chongqing, China.
3
    The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Abstract

Hepatitis B virus (HBV) infection is a challenging public health problem in China and worldwide. Mother-to-child transmission is one of the main transmission routes of HBV in highly endemic regions. However, the mechanisms of HBV perinatal transmission in children have not been clearly defined. The aim of this study was to demonstrate the association between single-nucleotide polymorphisms (SNPs) in IFN-γ signaling pathway and HBV infection or breakthrough infection in children. Two hundred and seventy-four HBV-infected children defined as test positive for hepatitis B surface antigen (HBsAg) and 353 controls defined as negative for HBsAg in China were recruited from October 2013 to May 2015. SNPs in IFN-γ signaling pathway including IFNG, IFNGR1, IFNGR2, and IL12B were genotyped. Rs2234711 in IFNGR1 was significantly associated with HBV infection in children (OR = 0.641, 95% CI: 0.450-0.913). In addition, rs2234711 was also significantly associated with HBV breakthrough infection in children born to HBsAg-positive mothers (OR = 0.452, 95% CI: 0.205-0.998). Our study confirmed that genetic variants in IFN-γ signaling pathway have significant associations with HBV infection, especially with HBV breakthrough in children. This study provides insight into HBV infection in children and could be used to help design effective strategies for reducing immunoprophylaxis failure.

Copyright © 2020 Yang Zhuo et al.

PMID:
    32047575
PMCID:
    PMC7001665
DOI:
    10.1155/2020/8121659

StephenW

可以J感染Dis Med微生物。 2020年1月22日； 2020：8121659。土井：10.1155 / 2020/8121659。 ECollection 2020。
IFN-γ信号通路中的单核苷酸多态性与中国儿童乙型肝炎病毒感染的风险相关。
卓Y1，杨Y1，张M2，徐Y1，陈Z2，穆L1，唐X1，钟Z1，陈J3，周L1。
作者信息

1个
重庆医科大学公共卫生与管理学院流行病学教研室，重庆
2
重庆市九龙坡区人民医院。
3
重庆医科大学附属第二医院传染病科，病毒性肝炎研究所，中国教育部指定的传染病分子生物学重点实验室。

抽象

乙型肝炎病毒（HBV）感染是中国乃至全球范围内一个充满挑战的公共健康问题。母婴传播是高流行地区乙肝病毒的主要传播途径之一。但是，儿童HBV围产期传播的机制尚未明确。这项研究的目的是证明儿童IFN-γ信号通路中的单核苷酸多态性（SNP）与HBV感染或突破性感染之间的关联。 2013年10月至2015年5月，在中国招募了274名被乙型肝炎表面抗原（HBsAg）测试阳性的儿童和353名被定义为HBsAg阴性的对照。在IFN-γ信号通路中包括IFNG的SNP分别对IFNGR1，IFNGR2和IL12B进行基因分型。 IFNGR1中的Rs2234711与儿童HBV感染显着相关（OR = 0.641，95％CI：0.450-0.913）。此外，rs2234711也与HBsAg阳性母亲出生的孩子的HBV突破感染密切相关（OR = 0.452，95％CI：0.205-0.998）。我们的研究证实，IFN-γ信号通路中的遗传变异与HBV感染，尤其是儿童的HBV突破有显着关联。这项研究提供了对儿童HBV感染的见识，可用于帮助设计减少免疫预防失败的有效策略。

版权所有©2020杨卓等。

PMID：
32047575
PMCID：
PMC7001665
DOI：
10.1155 / 2020/8121659

StephenW

http://downloads.hindawi.com/journals/cjidmm/2020/8121659.pdf