HBV感染母亲的胎儿的长期生长和骨骼发育，无论胎儿是否接

StephenW

J Hepatol. 2020 Feb 7. pii: S0168-8278(20)30062-3. doi: 10.1016/j.jhep.2020.01.021. [Epub ahead of print]
Long-term growth and bone development in children of HBV-infected mothers with and without fetal exposure to tenofovir disoproxil fumarate.
Wen WH1, Chen HL2, Ting-Fang Shih T3, Wu JF4, Ni YH4, Lee CN5, Zhao LL6, Lai MW7, Mu SC8, Tung YC4, Hsu HY2, Chang MH9; Taiwan Study Group for the Prevention of Mother-to-Infant Transmission of HBV (PreMIT study).
Author information

1
    Department of Pediatrics, Cardinal Tien Hospital, New Taipei City, Taiwan; School of Medicine, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.
2
    Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan; Department and Graduate Institute of Medical Education and Bioethics, College of Medicine, National Taiwan University, Taipei, Taiwan.
3
    Department of Radiology, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan.
4
    Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan.
5
    Department of Obstetrics and Gynecology, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan.
6
    Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
7
    Division of Pediatric Gastroenterology, Department of Pediatrics; Liver Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taiwan.
8
    Department of Pediatrics, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
9
    Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan. Electronic address: [email protected].

Abstract
BACKGROUND & AIMS:

Long-term safety outcome of children with fetal exposure to tenofovir disoproxil fumarate (TDF) to prevent maternal transmission of hepatitis B virus (HBV) is lacking.
METHODS:

Children participating in a prospective, multisite trial of maternal TDF treatment during late pregnancy were recruited for follow-up visit once a year. Growth parameters, serum biochemistry, HBV serology, and bone mineral density (BMD) by dual-energy x-ray absorptiometery scan were measured.
RESULTS:

One hundred and twenty-eight children, 71 in TDF and 57 in control group, completed 255 follow-up visits at the age of 2 to 7 (median, 4.08) years. No differences in z-scores for weight-for-age (0.26 ± 0.90 vs. 0.22 ± 0.99, P = 0.481), z-scores for height-for-age (0.20 ± 1.02 vs. 0.25 ± 0.98, P = 0.812), and estimated glomerular filtration rate (169.12 ± 50.48 vs. 169.06 ± 34.46 ml/min/1.73mˆ2, P = 0.479) were detected. After adjustment for age, sex and HBV status by multiple linear regression, children in TDF and control group had comparable levels of serum calcium (2.61 ± 0.02 vs. 2.57 ± 0.02 mmol/L, P = 0.115), phosphorus (5.29 ± 0.05 vs. 5.23 ± 0.05 mg/dL, P = 0.379), bone specific alkaline phosphatase (64.22 ± 1.68 vs. 63.35 ± 1.90 μg/L, P = 0.736), calcidiol (33.25 ± 0.70 vs. 32.82 ± 0.80 ng/mL, P = 0.687) and BMD of lumbar spines (0.55 ± 0.01 vs. 0.57 ± 0.01 g/cmˆ2, P = 0.159) and left hip (0.56 ± 0.01 vs. 0.56 ± 0.01 g/cmˆ2, P = 0.926).
CONCLUSIONS:

Children of HBV mothers with and without TDF treatment during late pregnancy had comparable long-term growth, renal function, and bone development up to 6-7 years after delivery.

Copyright © 2020 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
KEYWORDS:

antiviral therapy; bone mineral density; maternal transmission; mother-to-infant transmission; perinatal transmission; pregnancy; vertical transmission

PMID:
    32044401
DOI:
    10.1016/j.jhep.2020.01.021

StephenW

J肝素。 2020年2月7日。pii：S0168-8278（20）30062-3。 doi：10.1016 / j.jhep.2020.01.021。 [Epub提前发行]
HBV感染母亲的胎儿的长期生长和骨骼发育，无论胎儿是否接触富马酸替诺福韦酯。
温WH1，陈HL2，施廷芳T3，吴JF4，倪YH4，李CN5，赵LL6，赖MW7，穆SC8，董YC4，许HY2，张MH9;台湾预防乙肝母婴传播研究小组（PreMIT研究）。
作者信息

1个
    台湾新北市红衣主教医院儿科台湾新北市辅仁大学医学院医学院。
2
    国立台湾大学医学院附属医院儿科，台湾台北；国立台湾大学医学院医学教育与生命伦理学系和研究生院，台湾台北。
3
    国立台湾大学医学院附属医院放射科，台湾台北。
4
    国立台湾大学医学院附属医院儿科，台湾台北。
5
    国立台湾大学医学院附属医院妇产科，台北。
6
    台湾新北市佛教慈济医学基金会台北慈济医院儿科。
7
    儿科消化科台湾林口分院长庚纪念医院肝脏研究中心。
8
    台湾台北市新光吴和-纪念医院儿科。
9
    国立台湾大学医学院附属医院儿科，台湾台北。电子地址：[email protected]。

抽象
背景与目的：

缺乏胎儿暴露于替诺福韦二富马酸富马酸盐（TDF）预防儿童乙型肝炎病毒（HBV）母婴传播的长期安全性结局。
方法：

招募参加妊娠晚期母体TDF治疗的前瞻性，多地点试验的儿童，每年进行一次随访。通过双能X线骨密度仪测量生长参数，血清生化，HBV血清学和骨矿物质密度（BMD）。
结果：

一百二十八名儿童，其中在TDF中为71名，在对照组中为57名，在2至7岁（中位数为4.08）岁时完成了255次随访。年龄别体重的z得分无差异（0.26±0.90 vs.0.22±0.99，P = 0.481），年龄别体重的z得分（0.20±1.02 vs. 0.25±0.98，P = 0.812） ，并检测出估计的肾小球滤过率（169.12±50.48 vs. 169.06±34.46 ml / min / 1.73mˆ2，P = 0.479）。通过多元线性回归调整年龄，性别和HBV状况后，TDF组和对照组的儿童血清钙水平（2.61±0.02 vs. 2.57±0.02 mmol / L，P = 0.115），磷（5.29±0.05vs。 .5.23±0.05 mg / dL，P = 0.379），骨特异性碱性磷酸酶（64.22±1.68 vs. 63.35±1.90μg/ L，P = 0.736），骨化二醇（33.25±0.70 vs. 32.82±0.80 ng / mL，P = 0.687）和腰椎的BMD（0.55±0.01 vs. 0.57±0.01 g / cmˆ2，P = 0.159）和左髋骨（0.56±0.01 vs. 0.56±0.01 g / cmˆ2，P = 0.926）。
结论：

怀孕晚期接受或不接受TDF治疗的HBV母亲的孩子在分娩后的6-7年内具有相当的长期生长，肾功能和骨骼发育。

版权所有©2020欧洲肝病研究协会。由Elsevier B.V.发布。保留所有权利。
关键字：

抗病毒治疗；骨密度;孕产妇传播；母婴传播；围产期传播；怀孕;垂直传输

PMID：
    32044401
DOI：
    10.1016 / j.jhep.2020.01.021

StephenW

https://www.journal-of-hepatolog ... 8278(20)30062-3/pdf