亚洲的肝细胞癌：具有挑战性的情况。

StephenW

Euroasian J Hepatogastroenterol. 2019 Jan-Jun;9(1):27-33. doi: 10.5005/jp-journals-10018-1292.
Hepatocellular Carcinoma in Asia: A Challenging Situation.
Jafri W1, Kamran M2.
Author information

1
    Department of Medicine, Aga Khan University, Karachi, Pakistan.
2
    Department of Medicine, Baqai Medical University, Karachi, Pakistan.

Abstract

Amongst the primary tumors of the liver, hepatocellular carcinoma (HCC) is the most common. It is also one of the most prevalent types of cancers in Asia. Mostly, HCC occurs on a background of chronic liver disease and liver cirrhosis; however, de novo HCCs can also arise in apparently normal looking livers on imaging. There are multiple risk factors for HCC, including hepatitis B and C infections, diabetes mellitus, alcohol, and nonalcoholic steatohepatitis. Other common risk factors which are known to be involved in the pathogenesis of HCC are obesity, food contaminated with aflatoxin and hemochromatosis. Many of these factors are commonly found in this part of the world, hence the high burden of disease. Besides these, smoking and familial predisposition to HCC also seem to have an important role to play in its development. Majority of HCC are missed at an early stage despite the emphasis on adequate screening and surveillance strategies. Therefore, most of the time these tumors are diagnosed at a fairly advanced stage, when palliative treatment is the only therapeutic option left. Hence, prevention of HCC by controlling and minimizing the possible risk factors is the need of the hour. How to cite this article: Jafri W, Kamran M. Hepatocellular Carcinoma in Asia: A Challenging Situation. Euroasian J Hepatogastroenterol 2019; 9(1):27-33.

Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.
KEYWORDS:

Aflatoxin; Hepatitis B virus; Hepatitis C virus; Hepatocellular carcinoma; Nonalcoholic steatohepatitis

PMID:
    31988864
PMCID:
    PMC6969322
DOI:
    10.5005/jp-journals-10018-1292

StephenW

Euroasian J Hepatogastroenterol。 2019年1月-6月; 9（1）：27-33。 doi：10.5005 / jp-journals-10018-1292。
亚洲的肝细胞癌：具有挑战性的情况。
Jafri W1，Kamran M2。
作者信息

1个
    阿加汗大学医学系，巴基斯坦卡拉奇。
2
    巴基斯坦卡拉奇，Baqai医科大学医学系。

抽象

在肝脏的原发性肿瘤中，肝细胞癌（HCC）最常见。它也是亚洲最流行的癌症之一。肝癌通常发生在慢性肝病和肝硬化的背景下。然而，从影像学上看，看起来正常的肝脏也可能出现从头肝癌。肝癌有多种危险因素，包括乙型和丙型肝炎感染，糖尿病，酒精和非酒精性脂肪性肝炎。已知与HCC发病机理有关的其他常见危险因素是肥胖，黄曲霉毒素污染的食物和血色素沉着病。这些因素中的许多因素在世界这一地区很常见，因此疾病负担高。除此之外，吸烟和家族性肝癌的易感性似乎在其发展中也起着重要作用。尽管强调适当的筛查和监测策略，但早期仍会错过大多数HCC。因此，大多数情况下，当姑息治疗是唯一的治疗选择时，这些肿瘤被诊断为处于相当晚期。因此，通过控制和最小化可能的危险因素来预防HCC是一个小时的需求。如何引用本文：Jafri W，Kamran M.《亚洲肝细胞癌：具有挑战性的情况》。 Euroasian J Hepatogastroenterol 2019; 9（1）：27-33。

版权所有©2019; Jaypee Brothers Medical Publishers（P）Ltd.
关键字：

黄曲霉毒素;乙型肝炎病毒；丙型肝炎病毒；肝细胞癌；非酒精性脂肪性肝炎

PMID：
    31988864
PMCID：
    PMC6969322
DOI：
    10.5005 / jp-journals-10018-1292

StephenW

https://www.ejohg.com/doi/pdf/10.5005/jp-journals-10018-1292