维生素D与乙型肝炎病毒复制的关联：旁观者而非犯罪者

StephenW

J Formos Med Assoc. 2020 Jan 10. pii: S0929-6646(19)31147-7. doi: 10.1016/j.jfma.2019.12.004. [Epub ahead of print]
The association of vitamin D with hepatitis B virus replication: Bystander rather than offender.
Wang CC1, Tzeng IS2, Su WC3, Li CH3, Lin HH3, Yang CC4, Kao JH5.
Author information
Abstract
BACKGROUND/PURPOSE:

Low vitamin D is frequent in hepatitis B virus (HBV)-infected patients and several studies show an inverse association of serum vitamin D level with HBV viral load. However, the causal relationship remains unclear.
METHODS:

HBV carriers receiving regular 6-month surveillance without current antiviral treatment or cirrhosis were invited to participate into this trial. The markers of HBV replication included serum HBV DNA and quantitative HBsAg (qHBsAg) levels. Those with undetectable HBV DNA or sufficient vitamin D levels, cancer or electrolyte imbalance were excluded. The eligible subjects were randomized to receive either vitamin D supplement 2000 IU per day for 2 months (vitamin D group) or none (control group).
RESULTS:

A total of 196 HBV carriers (93 males and 103 females; mean age 51.9 ± 10.0 years) were screened. Of them, 28 patients had undetectable serum HBV DNA levels, which is defined as spontaneous viral clearance. The vitamin D levels were not different between patients with detectable HBV DNA and those without (p = 0.18). After exclusion, 149 patients were randomized to two groups: 75 in vitamin D group and 74 in control group. After 2 months vitamin D supplement, the serum vitamin D levels were significantly higher in the vitamin D group than the control group (p < 0.001). However, the serum qHBsAg and HBV DNA levels were comparable between these two groups.
CONCLUSION:

There is no causal relationship between vitamin D and HBV replication. The role of liver reserve on serum vitamin D levels in patients with chronic HBV infection needs further investigation.

Copyright © 2020. Published by Elsevier B.V.
KEYWORDS:

HBV DNA; Hepatitis B virus; Quantitative HBsAg; Vitamin D

PMID:
    31932201
DOI:
    10.1016/j.jfma.2019.12.004

StephenW

J Formos Med副教授。 2020年1月10日。pii：S0929-6646（19）31147-7。 Doi：10.1016 / j.jfma.2019.12.004。 [Epub提前发布]
维生素D与乙型肝炎病毒复制的关联：旁观者而非犯罪者。
Wang CC1，Tzeng IS2，Su WC3，Li CH3，Lin HH3，Yang CC4，Kao JH5。
作者信息
抽象
背景/目的：

乙型肝炎病毒（HBV）感染的患者中维生素D含量较低，几项研究表明血清维生素D水平与HBV病毒载量呈负相关。但是，因果关系仍然不清楚。
方法：

未经常规抗病毒治疗或肝硬化接受定期6个月监测的HBV携带者应邀参加该试验。 HBV复制的标志物包括血清HBV DNA和定量HBsAg（qHBsAg）水平。 HBV DNA检测不到或维生素D水平充足，癌症或电解质紊乱的患者被排除在外。符合条件的受试者被随机分配接受维生素D补充剂每天2000 IU，持续2个月（维生素D组）或不接受（对照组）。
结果：

总共筛选了196例HBV携带者（男性93例，女性103例；平均年龄51.9±10.0岁）。其中，有28名患者的血清HBV DNA水平无法检测到，这被定义为自发病毒清除。可以检测到HBV DNA的患者与未检测到HBV DNA的患者之间的维生素D水平没有差异（p = 0.18）。排除后，将149例患者随机分为两组：维生素D组75例和对照组74例。补充维生素D 2个月后，维生素D组的血清维生素D水平显着高于对照组（p <0.001）。但是，两组的血清qHBsAg和HBV DNA水平相当。
结论：

维生素D与HBV复制之间没有因果关系。肝储备对慢性HBV感染患者血清维生素D水平的作用尚待进一步研究。

版权所有©2020。由Elsevier B.V.发布。
关键字：

HBV DNA；乙型肝炎病毒；定量HBsAg；维生素D

PMID：
31932201
DOI：
10.1016 / j.jfma.2019.12.004

StephenW

https://www.sciencedirect.com/sc ... 19311477?via%3Dihub

neilhbver

如果时间拉长到5年10年，没准能看出区别