血清几丁质酶3样1在乙型肝炎相关的慢性肝病中的临床意义。

StephenW

J Clin Lab Anal. 2020 Jan 8:e23200. doi: 10.1002/jcla.23200. [Epub ahead of print]
The clinical significance of serum chitinase 3-like 1 in hepatitis B-related chronic liver diseases.
Jiang Z1,2, Wang S1,2, Jin J2, Ying S1, Chen Z1, Zhu D1, Xiao B2, Hu Y1,3, Qian Y1, Cai T3, Fu L1,2,3.
Author information

1
    Department of Hepatology, HwaMei Hospital, University Of Chinese Academy Of Sciences, Ningbo, China.
2
    Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, China.
3
    Key Laboratory of Diagnosis and Treatment of Digestive System tumors of Zhejiang Province, Ningbo, China.

Abstract
AIM:

In the present study, we purposed to determine serum chitinase 3-like 1 (CHI3L1) expression characteristics in chronic liver diseases monoinfected with hepatitis B virus and analyze its diagnostic value in liver fibrosis.
METHODS:

A total of 467 chronic hepatitis B (CHB) patients, 312 liver cirrhosis (LC) patients, and 104 hepatocellular carcinoma (HCC) patients at our institution were enrolled, and clinical indicators were analyzed.
RESULTS:

Our data have shown that the expression level of serum CHI3L1 was steadily increased from CHB to LC to HCC (P < .001). Serum CHI3L1 expression levels were positively associated with liver stiffness measurement (LSM), fibrosis-4 (FIB-4) index, aspartate aminotransferase-to-platelet ratio index (APRI), and HCC stage. The receiver operating characteristic (ROC) curve proved that serum CHI3L1 was superior to other noninvasive methods (LSM, FIB-4, and APRI) with an area under the ROC curve (AUC) of 0.97 in diagnosing significant fibrosis.
CONCLUSIONS:

Serum CHI3L1 harbors significant clinical value in chronic liver diseases infected with hepatitis B virus, especially in the diagnosis of fibrosis.

© 2020 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc.
KEYWORDS:

CHI3L1; diagnosis; hepatitis B; hepatocellular carcinoma; liver fibrosis

PMID:
    31916309
DOI:
    10.1002/jcla.23200

StephenW

J临床实验室肛门。 2020年1月8日：e23200。 doi：10.1002 / jcla.23200。 [Epub提前发布]
血清几丁质酶3样1在乙型肝炎相关的慢性肝病中的临床意义。
姜Z1,2，王S1,2，金J2，英S1，陈Z1，朱D1，肖B2，胡Y1,3，钱Y1，蔡T3，傅L1,2,3。
作者信息

1个
    中国科学院大学附属华美医院肝病科，宁波
2
    宁波大学医学院生物化学与分子生物学系，浙江省病理生理学重点实验室，宁波
3
    浙江省消化系统肿瘤诊治重点实验室，宁波。

抽象
目标：

在本研究中，我们旨在确定在单株感染乙型肝炎病毒的慢性肝病中血清几丁质酶3样1（CHI3L1）的表达特征，并分析其在肝纤维化中的诊断价值。
方法：

我院共纳入467例慢性乙型肝炎（CHB）患者，312例肝硬化（LC）患者和104例肝细胞癌（HCC）患者，并分析其临床指标。
结果：

我们的数据表明，血清CHI3L1的表达水平从CHB到LC到HCC稳定增加（P <.001）。血清CHI3L1表达水平与肝硬度测量（LSM），纤维化4（FIB-4）指数，天冬氨酸氨基转移酶与血小板比率指数（APRI）和HCC分期呈正相关。接受者操作特征（ROC）曲线证明血清CHI3L1在诊断显着纤维化方面优于ROC曲线下面积（AUC）为0.97的其他非侵入性方法（LSM，FIB-4和APRI）。
结论：

血清CHI3L1在感染了乙型肝炎病毒的慢性肝病中具有重要的临床价值，尤其是在纤维化的诊断方面。

©2020作者。 Wiley Periodicals，Inc.出版的《临床实验室分析杂志》。
关键字：

CHI3L1;诊断;乙型肝炎；肝细胞癌；肝纤维化

PMID：
    31916309
DOI：
    10.1002 / jcla.23200

StephenW

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcla.23200