乙肝相关慢性肝病患者的乙肝病毒活性与肝脂肪变性程度无

StephenW

Liver Int. 2019 Dec 28. doi: 10.1111/liv.14344. [Epub ahead of print]
Hepatitis B virus activity is not associated with degree of liver steatosis in patients with Hepatitis B-related chronic liver disease.
Worland T1, Apostolov R1, Asadi K1, Leung C1.
Author information

1
    Austin Health, Melbourne, Australia.

Abstract
BACKGROUND & AIMS:

The recently published manuscript by Zhu and colleagues "Hepatitis B virus infection and risk of non-alcoholic fatty liver disease: A population-based cohort study" found no correlation between presence of chronic HBV and presence of common risk factors for non-alcoholic fatty liver disease on primary analysis. A limitation to this study, like most population based research, is the absence of liver histology, which is considered gold standard for assessment of non-alcoholic fatty liver disease.
METHODS:

Our group studied the association between hepatitis B viral activity and non-alcoholic fatty liver disease activity as measured by grade of steatohepatitis/fibrosis on liver biopsy by analysing consecutive liver histology samples from patients with chronic hepatitis B at a single quaternary liver transplant centre.
RESULTS:

Linear regression modelling for active viral hepatitis on histologic examination against degree of steatohepatitis showed no correlation (r2 0.018, all P>0.1). Linear regression of degree of steatohepatitis versus hepatitis B viral load also showed no correlation.
CONCLUSIONS:

Our work is concordant with the manuscript from Zhu et al; we found no significant correlation between hepatitis B viral activity and degree of steatohepatitis.

© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
KEYWORDS:

Hepatitis B; Non-alcoholic fatty liver disease; fatty liver

PMID:
    31883410
DOI:
    10.1111/liv.14344

StephenW

肝内科。 2019十二月28. doi：10.1111 / liv.14344。 [Epub提前发布]
乙肝相关慢性肝病患者的乙肝病毒活性与肝脂肪变性程度无关。
Worland T1，Apostolov R1，Asadi K1，Leung C1。
作者信息

1个
    澳大利亚墨尔本，奥斯汀健康中心。

抽象
背景与目的：

朱和同事最近发表的手稿“乙型肝炎病毒感染和非酒精性脂肪肝的风险：一项基于人群的队列研究”发现慢性乙肝病毒的存在与非酒精性脂肪肝的常见危险因素之间没有关联疾病初步分析。像大多数基于人群的研究一样，该研究的局限性是缺乏肝脏组织学，肝脏组织学被认为是评估非酒精性脂肪性肝病的金标准。
方法：

我们的小组通过在单个四级肝移植中心分析连续的慢性乙型肝炎患者的肝组织学样本，研究了根据活检的脂肪性肝炎/纤维化等级对乙型肝炎病毒活性与非酒精性脂肪肝疾病活动之间的关系。
结果：

组织学检查脂肪性肝炎程度的活动性病毒性肝炎的线性回归模型显示无相关性（r2 = 0.018，所有P> 0.1）。脂肪性肝炎程度与乙型肝炎病毒载量的线性回归也没有相关性。
结论：

我们的工作与朱等人的手稿相吻合。我们发现乙型肝炎病毒活性与脂肪性肝炎程度之间无显着相关性。

分级为4 +©2019 John Wiley＆Sons A / S。由John Wiley＆Sons Ltd.发布。
关键字：

乙型肝炎；非酒精性脂肪肝疾病；脂肪肝

PMID：
    31883410
DOI：
    10.1111 / liv.14344