3例肝细胞癌用质子束治疗4次。

StephenW

Mol Clin Oncol. 2020 Jan;12(1):31-35. doi: 10.3892/mco.2019.1950. Epub 2019 Nov 18.
Three cases of hepatocellular carcinoma treated 4 times with proton beams.
Murakami M1, Fukumitsu N2, Okumura T1, Numajiri H1, Murofushi K1, Ohnishi K1, Mizumoto M1, Ishikawa H1, Tsuboi K1, Sakurai H1.
Author information

1
    Department of Radiation Oncology and Proton Medical Research Center, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8576, Japan.
2
    Department of Radiation Oncology, Kobe Proton Center, Kobe. Hyōgo 650-0047, Japan.

Abstract

HCC may recur following surgery or radiofrequency ablation. Proton beam therapy (PBT) is a type of radiotherapy that achieves excellent local control of HCC without severe toxicity. The present study reported the long-term outcome of 3 HCC patients who each received 4 repeat courses of PBT. All patients had a hepatitis B or C viral infection. A total of 14 lesions were treated using a curative PBT protocol and irradiated liver volumes in each treatment were 7-50% of the total liver volume. Liver function in all cases was considerably preserved until the last follow-up and patient survival was 51-107 months from the first PBT with no local recurrence observed in the 14 lesions. The presented cases indicated that repeated PBT is an effective treatment option for recurrent HCC due to reduced liver damage and superior local treatment compared with other treatment options such as transarterial chemoembolization.

Copyright: © Murakami et al.
KEYWORDS:

hepatocellular carcinoma; irradiated liver volume; proton beam therapy; repeated proton beam therapy; total liver volume

PMID:
    31814974
PMCID:
    PMC6888171
DOI:
    10.3892/mco.2019.1950

StephenW

摩尔临床Oncol。 2020年1月； 12（1）：31-35。 Doi：10.3892 / mco.2019.1950。 EPUB 2019年11月18日
3例肝细胞癌用质子束治疗4次。
村上M1，福光N2，大仓T1，沼ji H1，室富士K1，大西K1，水本M1，石川H1，坪K1，樱井H1。
作者信息

1个
日本筑波大学筑波大学医学部放射肿瘤科和质子医学研究中心，茨城县305-8576。
2
神户神户质子中心放射肿瘤学系。日本兵库650-0047。

抽象

手术或射频消融后可能会复发HCC。质子束疗法（PBT）是一种放射疗法，可实现HCC的出色局部控制，而无严重毒性。本研究报告了3例HCC患者的长期预后，每例患者均接受4个PBT重复疗程。所有患者均患有乙型或丙型肝炎病毒感染。使用治愈性PBT方案治疗了总共14个病变，每次治疗的照射肝脏体积占总肝脏体积的7-50％。在所有病例中，肝功能基本得以保留，直到最后一次随访为止，患者的生存期从首次PBT起为51-107个月，在14个病变中未观察到局部复发。提出的病例表明，与其他治疗方案（如经动脉化学栓塞术）相比，由于减少的肝损伤和优越的局部治疗，重复PBT是复发性HCC的有效治疗方案。

版权：©村上等。
关键字：

肝细胞癌；肝脏辐射量质子束治疗重复质子束治疗；肝脏总体积

PMID：
31814974
PMCID：
PMC6888171
DOI：
10.3892 / mco.2019.1950

StephenW

www.spandidos-publications.com/10.3892/mco.2019.1950/download