使用声辐射力脉冲成像对点剪切波弹性成像进行评估，以评

StephenW

J Clin Med. 2019 Dec 2;8(12). pii: E2101. doi: 10.3390/jcm8122101.
Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection.
Graf C1, Mondorf A1, Knop V1, Peiffer KH1, Dietz J1, Friess J1, Wedemeyer H2,3, Buggisch P4, Mauss S5, Berg T6, Rausch M7, Sprinzl M8, Klinker H9, Hinrichsen H10, Bronowicki JP11, Haag S12, Hüppe D13, Lutz T14, Poynard T15, Zeuzem S1, Friedrich-Rust M1, Sarrazin C1,16, Vermehren J1.
Author information

1
    Department of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany.
2
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30625 Hannover, Germany.
3
    Department of Gastroenterology and Hepatology, University Hospital Essen, 45147 Essen, Germany.
4
    Institute for Interdisciplinary Medicine IFI, 20099 Hamburg, Germany.
5
    Center for HIV and Hepatogastroenterology, 40237 Düsseldorf, Germany.
6
    Department of Gastroenterology and Rheumatology, University Hospital Leipzig, 04103 Leipzig, Germany.
7
    Practice of Internal Medicine, 10777 Berlin, Germany.
8
    Department of Internal Medicine I, University Medical Centre of the Johannes Gutenberg-University, 55131 Mainz, Germany.
9
    Department of Medicine II, Division of Hepatology, University Hospital Würzburg, 97080 Würzburg, Germany.
10
    Gastroenterology-Hepatology Center, 24105 Kiel, Germany.
11
    Hepato-Gastroenterology, Hopital Brabois- CHU Nancy, 54500 Vandoeuvre-les-Nancy, France.
12
    Practice of Gastroenterology, 65189 Wiesbaden, Germany.
13
    Practice of Hepatology, 44623 Herne, Germany.
14
    Infektiologikum, 60596 Frankfurt, Germany.
15
    BioPredictive, 75007 Paris, France.
16
    Department of Gastroenterology, St. Josefs-Hospital, 65189 Wiesbaden, Germany.

Abstract
BACKGROUND:

Accurate assessment of hepatic fibrosis in patients with chronic HBeAg-negative Hepatitis B is of crucial importance not only to predict the long-term clinical course, but also to evaluate antiviral therapy indication. The aim of this study was to prospectively assess the utility of point shear wave elastography (pSWE) for longitudinal non-invasive fibrosis assessment in a large cohort of untreated patients with chronic HBeAg-negative hepatitis B virus (HBV) infection.
METHODS:

407 consecutive patients with HBeAg-negative HBV infection who underwent pSWE, transient elastography (TE) as well as laboratory fibrosis markers, including fibrosis index based on four factors (FIB-4), aspartate to platelet ratio index (APRI) and FibroTest, on the same day were prospectively followed up for six years. Patients were classified into one of the three groups: inactive carriers (IC; HBV-DNA <2000 IU/mL and ALT <40 U/L); grey zone group 1 (GZ-1; HBV DNA <2000 IU/mL and ALT >40 U/L); grey zone group 2 (GZ-2; HBV-DNA >2000 IU/mL and ALT <40 U/L).
RESULTS:

pSWE results were significantly correlated with TE (r = 0.29, p < 0.001) and APRI (r = 0.17; p = 0.005). Median pSWE values did not differ between IC, GZ-1 and GZ-2 patients (p = 0.82, p = 0.17, p = 0.34). During six years of follow-up, median pSWE and TE values did not differ significantly over time (TE: p = 0.27; pSWE: p = 0.05).
CONCLUSION:

Our data indicate that pSWE could be useful for non-invasive fibrosis assessment and follow-up in patients with HBeAg-negative chronic HBV infection.
KEYWORDS:

APRI; FIB-4; HBV; acoustic radiation force impulse imaging; fibrotest; non-invasive fibrosis assessment; point shear wave elastography; transient elastography

PMID:
    31810183
DOI:
    10.3390/jcm8122101

StephenW

J临床医学。 2019年12月2日; 8（12）。 Pii：E2101。 Doi：10.3390 / jcm8122101。
使用声辐射力脉冲成像对点剪切波弹性成像进行评估，以评估HBeAg阴性HBV感染患者的纵向纤维化。
Graf C1，Mondorf A1，Knop V1，Peiffer KH1，Dietz J1，Friess J1，Wedemeyer H2,3，Buggisch P4，Mauss S5，Berg T6，Rausch M7，Sprinzl M8，Klinker H9，Hinrichsen H10，Bronowicki JP11，Haag S12， HüppeD13，Lutz T14，Poynard T15，Zeuzem S1，Friedrich-Rust M1，Sarrazin C1,16，Vermehren J1。
作者信息

1个
法兰克福大学医院内科1，德国法兰克福60596。
2
汉诺威医学院消化内科，肝内分泌科，德国汉诺威30625。
3
埃森大学医院消化内科和肝病科，德国埃森45147。
4
IFI跨学科医学研究所，20099，德国汉堡。
5
艾滋病毒和肝消化病学中心，德国杜塞尔多夫40237。
6
莱比锡大学医院消化内科和风湿病科，德国莱比锡04103。
7
内科医学实践，德国柏林10777。
8
约翰内斯·古腾堡大学大学医学中心内科一，德国美因兹55131。
9
维尔茨堡大学医院，肝病科，第二医学系，德国维尔茨堡97080。
10
胃肠病学-肝病中心，德国基尔24105。
11
肝肠胃病，霍皮塔尔·布拉博伊斯-南希，54500，法国Vandoeuvre-les-Nancy。
12
胃肠病学实践，德国威斯巴登65189。
13
肝病学实践，44623 Herne，德国。
14
Infektiologikum，60596法兰克福，德国。
15
BioPredictive，75007法国巴黎。
16
圣约瑟夫医院消化内科，德国威斯巴登65189。

抽象
背景：

准确评估慢性HBeAg阴性乙型肝炎患者的肝纤维化不仅对预测长期临床病程，而且对评估抗病毒治疗指征至关重要。这项研究的目的是前瞻性评估点剪切波弹性成像（pSWE）在大量未经治疗的慢性HBeAg阴性乙型肝炎病毒（HBV）感染患者中进行纵向非侵入性纤维化评估的效用。
方法：

连续407例HBeAg阴性HBV感染患者接受了pSWE，瞬时弹性成像（TE）以及实验室纤维化标记，包括基于四个因素的纤维化指数（FIB-4），门冬氨酸与血小板比率指数（APRI）和FibroTest，同一天进行了长达六年的随访。患者被分为三类之一：无活动的携带者（IC； HBV-DNA <2000 IU / mL，ALT <40 U / L）；灰区组1（GZ-1; HBV DNA <2000 IU / mL和ALT> 40 U / L）;灰区组2（GZ-2; HBV-DNA> 2000 IU / mL和ALT <40 U / L）。
结果：

pSWE结果与TE（r = 0.29，p <0.001）和APRI（r = 0.17; p = 0.005）显着相关。 IC，GZ-1和GZ-2患者之间的中位pSWE值没有差异（p = 0.82，p = 0.17，p = 0.34）。在六年的随访期间，中位pSWE和TE值随时间变化不显着（TE：p = 0.27; pSWE：p = 0.05）。
结论：

我们的数据表明，pSWE可用于HBeAg阴性慢性HBV感染患者的非侵入性纤维化评估和随访。
关键字：

APRI； FIB-4；乙肝病毒声辐射力脉冲成像；纤维测试无创纤维化评估；点剪切波弹性成像瞬时弹性成像

PMID：
31810183
DOI：
10.3390 / jcm8122101

StephenW

https://www.mdpi.com/2077-0383/8/12/2101/pdf