靶向PD-L1表达的新型肝定向锁定核酸可逆转HBV特异性免疫耐受

StephenW

A novel liver-directed locked nucleic acid targeting PD-L1 expression reverts HBV-specific immune tolerance and induces sustained clearance of HBV infection                                                                         AASLD 2019 Nov 8-12 Boston Reported by Jules Levin JieZhao2, LykkePedersen3, Julie Blaising1, Malika Ait-Goughoulte1, Fang Shen2, YoujunYu2, Johanna Walther1,Anna-Maria Geretti1, Timothy Tellinghuisen1, John AT Young1,  SørenOttosen3and Souphalone Luangsay1 1Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland 2Roche Innovation Center Shanghai, Shanghai, China 3Roche Innovation Center Copenhagen, Hørsholm, Denmark