通过组织工程学进行肝组织再生的最新进展

StephenW

Current progress in hepatic tissue regeneration by tissue engineering

    Vahid Hosseini, Nazila Fathi Maroufi, Sepideh Saghati, Nahideh Asadi, Masoud Darabi, Saeed Nazari Soltan Ahmad, Hosseini Hosseinkhani & Reza Rahbarghazi

Journal of Translational Medicine volume 17, Article number: 383 (2019) Cite this article
Abstract
Background

Liver, as a vital organ, is responsible for a wide range of biological functions to maintain homeostasis and any type of damages to hepatic tissue contributes to disease progression and death. Viral infection, trauma, carcinoma, alcohol misuse and inborn errors of metabolism are common causes of liver diseases are a severe known reason for leading to end-stage liver disease or liver failure. In either way, liver transplantation is the only treatment option which is, however, hampered by the increasing scarcity of organ donor. Over the past years, considerable efforts have been directed toward liver regeneration aiming at developing new approaches and methodologies to enhance the transplantation process. These approaches include producing decellularized scaffolds from the liver organ, 3D bio-printing system, and nano-based 3D scaffolds to simulate the native liver microenvironment. The application of small molecules and micro-RNAs and genetic manipulation in favor of hepatic differentiation of distinct stem cells could also be exploited. All of these strategies will help to facilitate the application of stem cells in human medicine. This article reviews the most recent strategies to generate a high amount of mature hepatocyte-like cells and updates current knowledge on liver regenerative medicine.
Background

StephenW

通过组织工程学进行肝组织再生的最新进展

    瓦希德·侯赛尼（Vahid Hosseini），纳齐拉·法蒂·马鲁菲（Nazila Fathi Maroufi），塞皮德·萨加蒂（Sepideh Saghati），纳西德·阿萨迪（Nahideh Asadi），马苏德·达拉比（Masoud Darabi），赛义德·纳扎里·索尔坦·艾哈迈德（Saetan Nahari）

Journal of转化医学杂志第17卷，文章编号：383（2019）引用本文
抽象
背景

肝脏作为重要器官，负责维持体内平衡的多种生物学功能，肝组织的任何类型损害均会导致疾病进展和死亡。病毒感染，创伤，癌，酒精滥用和先天性代谢错误是肝病的常见原因，是导致终末期肝病或肝衰竭的严重已知原因。无论哪种方式，肝移植是唯一的治疗选择，但是，器官供体的日益短缺阻碍了肝移植的发展。在过去的几年中，已经致力于肝脏再生，以开发新的方法和方法来增强移植过程。这些方法包括从肝脏器官中产生脱细胞的支架，3D生物打印系统以及基于纳米的3D支架以模拟天然肝脏微环境。还可以利用小分子和微小RNA的应用以及有利于不同干细胞肝分化的遗传操作。所有这些策略将有助于促进干细胞在人类医学中的应用。本文回顾了产生大量成熟肝细胞样细胞的最新策略，并更新了有关肝再生医学的最新知识。

StephenW

https://translational-medicine.b ... /s12967-019-02137-6

hp121

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这个是哪个国家的研究？？

StephenW

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伊朗(Iran)