HBeAg血清清除率的数学研究。

StephenW

Math Biosci Eng. 2019 Aug 20;16(6):7616-7658. doi: 10.3934/mbe.2019382.
Mathematical investigation of HBeAg seroclearance.
Kadelka S1, Ciupe SM1.
Author information

1
    Department of Mathematics, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

Abstract

Spontaneous or drug-induced loss of hepatitis B e antigen is considered a beneficial event in the disease progression of chronic hepatitis B virus infections. Mathematical models of within-host interactions are proposed; which provide insight into hepatitis B e antibody formation, its influence on hepatitis B e antigen seroclearance, and reversion of anergic cytotoxic immune responses. They predict that antibody expansion causes immune activation and hepatitis B e antigen seroclearance. Quantification of the time between antibody expansion and hepatitis B e antigen seroclearance in the presence and absence of treatment shows that potent short-term treatment speeds up the time between antibody expansion and hepatitis B e antigen seroclearance. The monthly hepatocyte turnover during this time can be increased or decreased by treatment depending on the amount of core promoter or precore mutated virus produced. The results can inform human interventions.
KEYWORDS:

HBeAb ; mathematical modeling ; dHBeAg ; hepatitis B ; seroclearance

PMID:
    31698631
DOI:
    10.3934/mbe.2019382

StephenW

数学生物工程。 2019八月20; 16（6）：7616-7658。 doi：10.3934 / mbe.2019382。
HBeAg血清清除率的数学研究。
Kadelka S1，Ciupe SM1。
作者信息

1个
    弗吉尼亚理工学院和州立大学数学系，布莱克斯堡，弗吉尼亚州24061，美国。

抽象

自发或药物诱导的乙型肝炎e抗原丢失被认为是慢性乙型肝炎病毒感染疾病进展中的有益事件。提出了主机内相互作用的数学模型。它提供了有关乙型肝炎e抗体形成，其对乙型肝炎e抗原血清清除的影响以及无反应性细胞毒性免疫反应的逆转的见解。他们预测抗体的扩增会引起免疫激活和乙型肝炎e抗原血清清除。在存在和不存在治疗的情况下，定量抗体扩增与B型肝炎e抗原血清清除之间的时间表明，有效的短期治疗可加快抗体扩增与b型肝炎e抗原血清清除之间的时间。根据产生的核心启动子或前核心突变病毒的数量，可以通过治疗增加或减少这段时间的每月肝细胞更新。结果可以为人为干预提供信息。
关键字：

乙肝抗体;数学建模;乙肝表面抗原;乙型肝炎;清除血清

PMID：
    31698631
DOI：
    10.3934 / mbe.2019382

StephenW

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