肝类器官：从基础研究到治疗应用

StephenW

Liver organoids: from basic research to therapeutic applications

    Nicole Prior1, Patricia Inacio1, Meritxell Huch1,2

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Abstract

Organoid cultures have emerged as an alternative in vitro system to recapitulate tissues in a dish. While mouse models and cell lines have furthered our understanding of liver biology and associated diseases, they suffer in replicating key aspects of human liver tissue, in particular its complex architecture and metabolic functions. Liver organoids have now been established for multiple species from induced pluripotent stem cells, embryonic stem cells, hepatoblasts and adult tissue-derived cells. These represent a promising addition to our toolbox to gain a deeper understanding of this complex organ. In this perspective we will review the advances in the liver organoid field, its limitations and potential for biomedical applications.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
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http://dx.doi.org/10.1136/gutjnl-2019-319256

StephenW

肝类器官：从基础研究到治疗应用

    妮可·普瑞尔（Nicole Prior1），帕特里夏·伊纳西奥（Patricia Inacio）1，梅里特塞尔（Meritxell Huch）1,2

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类器官培养物已经成为替代碗碟中组织组织的体外系统。尽管小鼠模型和细胞系进一步加深了我们对肝脏生物学和相关疾病的了解，但它们在复制人类肝脏组织的关键方面（尤其是其复杂的结构和代谢功能）方面受到了影响。现已建立了针对来自诱导性多能干细胞，胚胎干细胞，成肝细胞和成年组织衍生细胞的多种物种的肝类器官。这些代表了对我们工具箱的有前途的补充，以加深对这种复杂器官的了解。从这个角度来看，我们将回顾肝类器官领域的进展，其局限性以及在生物医学领域的潜力。

本文是根据知识共享署名4.0 Unported（CC BY 4.0）许可分发的开放获取文章，允许他人出于任何目的复制，重新分发，重新混合，转换和构建此作品，但要适当引用原始作品。 ，给出了许可证的链接，并指出是否进行了更改。请参阅：https：//creativecommons.org/licenses/by/4.0/。
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http://dx.doi.org/10.1136/gutjnl-2019-319256

StephenW

https://gut.bmj.com/content/68/1 ... p;utm_term=07112019