中国大陆慢性乙型肝炎患者代谢综合征对肝细胞癌风险的影

StephenW

Cancer Epidemiol Biomarkers Prev. 2019 Sep 18. pii: cebp.0303.2019. doi: 10.1158/1055-9965.EPI-19-0303. [Epub ahead of print]
The influence of metabolic syndrome on the risk of hepatocellular carcinoma in patients with chronic hepatitis B infection in mainland China.
Tan Y1, Zhang X2, Zhang W3, Tang L2, Yang H2, Yan K4, Jiang L2, Yang J2, Li C2, Yang J2, Wen T2, Tang H2, Yan L2.
Author information

1
    West China Hospital of Sichuan University [email protected].
2
    West China Hospital of Sichuan University.
3
    West China Medical Center of Sichuan University.
4
    West China School of Public Health.

Abstract
BACKGROUND:

The association between metabolic syndrome (MS), both in terms of its components and as a whole, and the risk of hepatocellular carcinoma (HCC) in subjects with hepatitis B virus (HBV) infection remains unclear, especially in mainland China.
METHODS:

We prospectively included 6,564 individuals with HBV infection from an initial cohort of 105,397 civil servants. The multivariate-adjusted hazard ratio (HR) and 95% confidence interval (95%CI) were evaluated using Cox proportional hazards models to explore the potential connection between HCC risk and MS. Cumulative incidences were plotted using Kaplan-Meier curves.
RESULTS:

After a 45,668.0 person-year follow-up (76.0±30.8 months) of 6,564 subjects who were seropositive for hepatitis B surface antigen (HBsAg), 89 incident HCC cases were identified. MS as a whole was independently associated with a 2-fold increased HCC risk (HR, 2.25, 95%CI: 1.41-3.60) after adjusting for age (in 1-year increment), gender, cigarette smoking, alcohol consumption, liver cirrhosis and elevated aspartate aminotransferase levels. Subjects with 3 or more factors and those with one or two factors had adjusted increased HCC risks of 2.12-fold (95%CI: 1.16-3.89) and 1.28-fold (95%CI:0.74-2.22), respectively, in comparison to those without any metabolic factors. Central obesity and type 2 diabetes were associated with significantly increased HCC risk, whereas this association was not observed in obese subjects (95%CI: 0.73-3.44).
CONCLUSION:

MS as a whole, central obesity and type 2 diabetes were independently associated with increased HCC risk in a population with HBV infection in mainland China.
IMPACT:

MS may be a risk factor for HCC.

Copyright ©2019, American Association for Cancer Research.

PMID:
    31533942
DOI:
    10.1158/1055-9965.EPI-19-0303

StephenW

癌症Epidemiol Biomarkers Prev。 2019年9月18日.pii：cebp.0303.2019。 doi：10.1158 / 1055-9965.EPI-19-0303。 [Epub提前发布]
中国大陆慢性乙型肝炎患者代谢综合征对肝细胞癌风险的影响。
Tan Y1，Zhang X2，Zhang W3，Tang L2，Yang H2，Yan K4，Jiang L2，Yang J2，Li C2，Yang J2，Wen T2，Tang H2，Yan L2。
作者信息

1
    四川大学华西医院[email protected]。
2
    四川大学华西医院。
3
    四川大学华西医学中心。
4
    华西公共卫生学院。

抽象
背景：

代谢综合征（MS）的成分和整体与乙型肝炎病毒（HBV）感染者的肝细胞癌（HCC）风险之间的关联仍不清楚，尤其是在中国大陆。
方法：

我们从最初的105,397名公务员队列中，预期纳入了6,564例HBV感染患者。使用Cox比例风险模型评估多变量校正风险比（HR）和95％置信区间（95％CI），以探索HCC风险与MS之间的潜在联系。使用Kaplan-Meier曲线绘制累积发生率。
结果：

在对5,564例乙型肝炎表面抗原（HBsAg）血清阳性的受试者进行了45,668.0人年的随访（76.0±30.8个月）后，确定了89例HCC病例。调整年龄（按一年递增），性别，吸烟，饮酒，肝硬化后，MS整体上与HCC风险增加2倍（HR，2.25、95％CI：1.41-3.60）相关。和升高的天冬氨酸转氨酶水平。与3个因素或更多因素以及具有一个或两个因素的受试者相比，调整后的HCC风险分别增加了2.12倍（95％CI：1.16-3.89）和1.28倍（95％CI：0.74-2.22）。没有任何代谢因素的人。中心性肥胖和2型糖尿病与HCC风险显着增加相关，而在肥胖受试者中未观察到这种相关性（95％CI：0.73-3.44）。
结论：

从整体上看，MS，中枢型肥胖和2型糖尿病与中国大陆HBV感染人群的HCC风险增加独立相关。
影响：

MS可能是HCC的危险因素。

美国癌症研究协会版权所有©2019。

结论：
    31533942
DOI：
    10.1158 / 1055-9965.EPI-19-0303