中国一般人群的乙型肝炎感染：系统评价和荟萃分析。

StephenW

BMC Infect Dis. 2019 Sep 18;19(1):811. doi: 10.1186/s12879-019-4428-y.
Hepatitis B infection in the general population of China: a systematic review and meta-analysis.
Wang H1, Men P2, Xiao Y2, Gao P1, Lv M1, Yuan Q1, Chen W1, Bai S1, Wu J3.
Author information

1
    Institute for immunization and prevention, Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, No.16, HePingLi Middle Street, DongCheng District, Beijing, 100013, China.
2
    China Institute of Medical Information/Medical Library, CAMS&PUMC, No. 69 Dongdan North Street, Dongcheng District, Beijing, 100005, China.
3
    Institute for immunization and prevention, Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, No.16, HePingLi Middle Street, DongCheng District, Beijing, 100013, China. [email protected].

Abstract
BACKGROUND:

Hepatitis B virus (HBV) infection is a major public health problem in China. Over a decade has passed since the last National Hepatitis Seroepidemiological Survey was conducted in 2006. The lack of updated data on hepatitis B in China makes assessing the current prevalence and burden of the disease inadequate. In response to the above situation, a systematic review and meta-analysis was conducted to provide a better understanding of hepatitis B epidemiology in the general population of China.
METHODS:

A systematic search was conducted in international databases (Medline through PubMed, EMBASE, Cochrane, Web of Science) and national databases (CBM, CNKI, WanFang Data) to retrieve primary studies published between January 1, 2013 and December 31, 2017. The pooled prevalence of HBV infection and 95% confidence intervals were calculated. Quality assessment, heterogeneity testing and publication bias assessment were also performed.
RESULTS:

Of the 27 studies included in the meta-analysis, the pooled estimated prevalence of HBV infection in the general population of China from 2013 to 2017 was 6.89% (95% CI:5.84-7.95%), which could be extrapolated to an estimated population of 84 million living with HBsAg in 2018. The prevalence of HBV infection in males was higher than that in females (5.88% vs 5.05%), and rural areas had a higher prevalence than urban areas (5.86% vs 3.29%). The highest prevalence of HBV infection was reported in Western provinces (8.92, 95% CI: 7.19-10.64%). In adults older than 20 years, the prevalence of HBV infection was approximately 7%, which was higher than that in children.
CONCLUSION:

The prevalence of HBV infection in the general population of China was classified as higher intermediate prevalence (5-7.99%), of which more than 90% of the HBV infection population included adults older than 20 years. The blocking of mother-to-infant hepatitis B transmission and plans involving timely birth dose of hepatitis B vaccine within 24 h should be implemented. Additionally, improving the quality of life and survival rate of the infected population through antiviral therapy and high-risk adult vaccination will be the priority of our future work. Moreover, various control measures should be implemented in different provinces across China.
KEYWORDS:

China; Hepatitis B; Meta-analysis; Prevalence

PMID:
    31533643
DOI:
    10.1186/s12879-019-4428-y

StephenW

BMC Infect Dis。 2019年9月18日; 19（1）：811。 doi：10.1186 / s12879-019-4428-y。
中国一般人群的乙型肝炎感染：系统评价和荟萃分析。
Wang H1，Men P2，Xiao Y2，Gao P1，Lv M1，Yuan Q1，Chen W1，Bai S1，Wu J3。
作者信息

1
    北京市东城区和平里中街16号，北京市疾病预防控制中心，北京市预防医学研究中心免疫与预防研究所，100013
2
    中国医学信息学院/医学图书馆，中国医学科学院，北京市东城区东单北街69号，邮编：100005
3
    北京市东城区和平里中街16号，北京市疾病预防控制中心，北京市预防医学研究中心免疫与预防研究所，100013 [email protected]。

抽象
背景：

乙型肝炎病毒（HBV）感染是中国主要的公共卫生问题。自2006年上一次全国肝炎血清流行病学调查以来，已经过去了十多年。中国缺乏关于乙型肝炎的最新数据，因此评估目前的患病率和疾病负担是不够的。针对上述情况，进行了系统评价和荟萃分析，以更好地了解中国一般人群的乙型肝炎流行病学。
方法：

在国际数据库（Medline通过PubMed，EMBASE，Cochrane，Web of Science）和国家数据库（CBM，CNKI，万方数据）中进行系统检索，以检索2013年1月1日至2017年12月31日期间发表的主要研究。计算HBV感染的患病率和95％置信区间。还进行了质量评估，异质性测试和发表偏倚评估。
结果：

在荟萃分析中纳入的27项研究中，2013年至2017年中国一般人群中HBV感染的汇总估计患病率为6.89％（95％CI：5.84-7.95％），可推算为估计人群2018年生活HBsAg的人数为8400万。男性HBV感染率高于女性（5.88％vs 5.05％），农村地区的患病率高于城市地区（5.86％vs 3.29％）。西部省份报告的HBV感染率最高（8.92,95％CI：7.19-10.64％）。在20岁以上的成年人中，HBV感染的患病率约为7％，高于儿童。
结论：

中国一般人群中HBV感染的流行程度被归类为较高的中间流行率（5-7.99％），其中超过90％的HBV感染人群包括20岁以上的成年人。应实施阻断母婴乙型肝炎传播和24小时内及时分娩乙型肝炎疫苗的计划。此外，通过抗病毒治疗和高风险成人疫苗接种来提高感染人群的生活质量和存活率将是我们未来工作的重点。此外，应在中国各省实施各种控制措施。
关键词：

中国;乙型肝炎; Meta分析;流行

结论：
    31533643
DOI：
    10.1186 / s12879-019-4428-Y

乙肝人1949

这位同学好执着，这种默默奉献的精神值得学习

小牡丹

瞎BB，没有可信度。