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J Pak Med Assoc. 2019 Sep;69(9):1279-1286.
Combined detection of AFP-L3, GP73 and TIP30 enhances diagnostic accuracy for HBV-related cirrhosis and hepatocellular carcinoma.
Yanming L1, Yue C2, Wencan C1, Liangyin WU1, Xijun L1, Jiafeng Z3, Fengping HE1.
Author information
1
Department of Clinical Laboratory, Yuebei People's Hospital, Shaoguan, Guangdong, P.R. China.
2
Department of Medical Technology, Medical College of Shaoguan University, Shaoguan, Guandong P.R. China.
3
Department of Hepatobiliary Surgery, Yuebei People's Hospital, Shaoguan, Guangdong, P.R. China.
Abstract
OBJECTIVE:
To investigate the value of combined tests of serum Golgi protein-73, alpha-fetoprotein- L3 and Tat-interacting protein-30 in the diagnosis of hepatitis B virus related cirrhosis and hepatocellular carcinoma.
METHODS:
The cross-sectional study was conducted at Yuebei People's Hospital, Guangdong, China, from January to October 2017, and comprised hepatitis B patients and healthy controls. Serum Golgi protein-73, alpha-fetoprotein-L3 and Tat-interacting protein-30 levels in both groups were detected by enzyme-linked immunosorbent assay (ELISA). Alpha-fetoprotein-L3 was separated and quantified by electrochemiluminescence immunoas says and the percentage of alpha-fetoprotein-L3 to alphafetoprotein was calculated.
RESULTS:
Of the 721 subjects, 525(%) were patients and 196(%) were healthy controls. Among the patients, 271(%) had chronic hepatitis B, 161(%) had liver cirrhosis and 93(%) had hepatocellular carcinoma. Serum Golgi protein-73, alpha-fetoprotein-L3 and Tat-interacting protein-30 levels were significantly different in the hepatocellular carcinoma patients compared to controls, and those with chronic hepatitis and liver cirrhosis (p<0.01 each). The sensitivity and specificity of the combined detection of the three serum levels for diagnosing cirrhosis were 78.26% and 86.72%. The corresponding values for diagnosing hepatocellular carcinoma were 86.02% and 92.51%.
CONCLUSIONS:
Combined detection of Golgi protein-73, alpha fetoprotein-L3 and Tat-interacting protein was found to have the potential to improve diagnostic accuracy.
KEYWORDS:
Hepatocellular carcinoma, Cirrhosis, Chronic hepatitis B, Tumour marker
PMID:
31511712 |
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