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肝胆相照论坛 论坛 学术讨论& HBV English 联合检测AFP-L3,GP73和TIP30可提高HBV相关肝硬化和肝细 ...
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联合检测AFP-L3,GP73和TIP30可提高HBV相关肝硬化和肝细胞癌的 [复制链接]

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发表于 2019-9-14 19:15 |只看该作者 |倒序浏览 |打印
J Pak Med Assoc. 2019 Sep;69(9):1279-1286.
Combined detection of AFP-L3, GP73 and TIP30 enhances diagnostic accuracy for HBV-related cirrhosis and hepatocellular carcinoma.
Yanming L1, Yue C2, Wencan C1, Liangyin WU1, Xijun L1, Jiafeng Z3, Fengping HE1.
Author information

1
    Department of Clinical Laboratory, Yuebei People's Hospital, Shaoguan, Guangdong, P.R. China.
2
    Department of Medical Technology, Medical College of Shaoguan University, Shaoguan, Guandong P.R. China.
3
    Department of Hepatobiliary Surgery, Yuebei People's Hospital, Shaoguan, Guangdong, P.R. China.

Abstract
OBJECTIVE:

To investigate the value of combined tests of serum Golgi protein-73, alpha-fetoprotein- L3 and Tat-interacting protein-30 in the diagnosis of hepatitis B virus related cirrhosis and hepatocellular carcinoma.
METHODS:

The cross-sectional study was conducted at Yuebei People's Hospital, Guangdong, China, from January to October 2017, and comprised hepatitis B patients and healthy controls. Serum Golgi protein-73, alpha-fetoprotein-L3 and Tat-interacting protein-30 levels in both groups were detected by enzyme-linked immunosorbent assay (ELISA). Alpha-fetoprotein-L3 was separated and quantified by electrochemiluminescence immunoas says and the percentage of alpha-fetoprotein-L3 to alphafetoprotein was calculated.
RESULTS:

Of the 721 subjects, 525(%) were patients and 196(%) were healthy controls. Among the patients, 271(%) had chronic hepatitis B, 161(%) had liver cirrhosis and 93(%) had hepatocellular carcinoma. Serum Golgi protein-73, alpha-fetoprotein-L3 and Tat-interacting protein-30 levels were significantly different in the hepatocellular carcinoma patients compared to controls, and those with chronic hepatitis and liver cirrhosis (p<0.01 each). The sensitivity and specificity of the combined detection of the three serum levels for diagnosing cirrhosis were 78.26% and 86.72%. The corresponding values for diagnosing hepatocellular carcinoma were 86.02% and 92.51%.
CONCLUSIONS:

Combined detection of Golgi protein-73, alpha fetoprotein-L3 and Tat-interacting protein was found to have the potential to improve diagnostic accuracy.
KEYWORDS:

Hepatocellular carcinoma, Cirrhosis, Chronic hepatitis B, Tumour marker

PMID:
    31511712

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62111 元 
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30437 
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2022-12-28 

才高八斗

2
发表于 2019-9-14 19:16 |只看该作者
J Pak Med Assoc。 2019年9月; 69(9):1279-1286。
联合检测AFP-L3,GP73和TIP30可提高HBV相关肝硬化和肝细胞癌的诊断准确性。
阎明L1,岳C2,文灿C1,吴良银1,西军L1,嘉丰Z3,冯平和1。
作者信息

1
广东省韶关市粤北人民医院检验科,中国。
2
韶关学院医学院医学技术系,广东韶关,中国。
3
广东省韶关市粤北人民医院肝胆外科,中国。

抽象
目的:

目的探讨血清Golgi蛋白-73,甲胎蛋白-L3和Tat相互作用蛋白-30联合检测对乙型肝炎病毒相关性肝硬化和肝细胞癌的诊断价值。
方法:

横断面研究于2017年1月至10月在中国广东省粤北人民医院进行,烧伤乙型肝炎患者和健康对照。血清高尔基体蛋白-73,甲胎蛋白-L3和Tat相互作用蛋白-30水平在两组中通过酶联免疫吸附测定(ELISA)检测。通过电化学发光免疫法分离并定量甲胎蛋白-L3,并计算甲胎蛋白-L3对甲胎蛋白的百分比。
结果:

在721名受试者中,525名(%)是患者,196名(%)是健康对照。在这些患者中,271(%)患有慢性乙型肝炎,161(%)患有肝硬化,93(%)患有肝细胞癌。与对照组和慢性肝炎和肝硬化患者相比,肝细胞癌患者的血清高尔基体蛋白-73,甲胎蛋白-L3和Tat相互作用蛋白-30水平显着不同(各自p <0.01)。联合检测三种血清水平诊断肝硬化的敏感性和特异性分别为78.26%和86.72%。诊断肝细胞癌的相应值分别为86.02%和92.51%。
结论:

发现高尔基体蛋白-73,甲胎蛋白-L3和Tat相互作用蛋白的组合检测具有提高诊断准确性的潜力。
关键词:

肝细胞癌,肝硬化,慢性乙型肝炎,肿瘤标志物

结论:
31511712

Rank: 8Rank: 8

现金
62111 元 
精华
26 
帖子
30437 
注册时间
2009-10-5 
最后登录
2022-12-28 

才高八斗

3
发表于 2019-9-14 19:16 |只看该作者
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