增加咖啡摄入量可降低HBeAg阴性感染中循环HBV DNA和HBsAg水平：

StephenW

Viruses. 2019 Sep 1;11(9). pii: E808. doi: 10.3390/v11090808.
Increased Coffee Intake Reduces Circulating HBV DNA and HBsAg Levels in HBeAg-Negative Infection: A Cohort Study.
Chook JB1, Ngeow YF2, Tee KK3, Lee JWT3, Mohamed R4.
Author information

1
    Department of Medical Sciences (DMS), School of Healthcare and Medical Sciences (SHMS), Sunway University, Bandar Sunway, Selangor Darul Ehsan 47500, Malaysia. [email protected].
2
    Department of Pre-Clinical Sciences, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Bandar Sungai Long, Selangor 43000, Malaysia.
3
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.
4
    Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.

Abstract

Coffee is hepatoprotective and potentially antiviral; however, its anti-hepatitis B virus (anti-HBV) property is not known in humans. This study investigated the influence of coffee drinking behaviour as well as clinical and biochemical profiles of hepatitis B e antigen (HBeAg) negative participants on circulating HBV DNA and hepatitis B surface antigen (HBsAg) levels at a 24-week interval. Exactly 114 chronically HBV-infected adult participants were enrolled from the University of Malaya Medical Centre (UMMC), Malaysia. A significant reduction of HBV DNA level was observed in those drinking three or more cups of coffee per day, with a median reduction of 523 IU/mL (P = 0.003). Reduction of HBsAg level was observed in those drinking two cups per day, with a median reduction of 37 IU/mL (P < 0.001). Multivariate analysis showed that increased coffee intake (P = 0.015) and lower ALT level (P = 0.033) were the significant predictors for a lower HBV DNA level, whereas increased coffee intake (P = 0.002) and having a family history of HBV infection (P = 0.021) were the significant predictors for a lower HBsAg level. These data suggest that drinking three cups or more coffee per day reduces circulating HBV DNA and HBsAg levels.
KEYWORDS:

antiviral; coffee; hepatitis B virus; surface antigen; viral load

PMID:
    31480588
DOI:
    10.3390/v11090808

StephenW

病毒。 2019年9月1日; 11（9）。 pii：E808。 doi：10.3390 / v11090808。
增加咖啡摄入量可降低HBeAg阴性感染中循环HBV DNA和HBsAg水平：一项队列研究。
Chook JB1，Ngeow YF2，Tee KK3，Lee JWT3，Mohamed R4。
作者信息

1
    医学科学系（DMS），医学和医学科学学院（SHMS），双威大学，Bandar Sunway，雪兰莪Darul Ehsan 47500，Malaysia。 [email protected]。
2
    印度尼西亚雪兰莪州Bandar Sungai Long大学医学与健康科学学院临床前科学系。
3
    马来西亚大学医学院医学微生物学系，吉隆坡50603，马来西亚。
4
    马来西亚大学医学院医学系，吉隆坡50603，马来西亚。

抽象

咖啡具有保肝作用，可能具有抗病毒作用;然而，它的抗乙型肝炎病毒（抗HBV）特性在人类中是未知的。本研究调查了乙型肝炎e抗原（HBeAg）阴性参与者的咖啡饮用行为以及24周间隔的HBV DNA和乙型肝炎表面抗原（HBsAg）水平的临床和生化特征的影响。来自马来西亚马来亚大学医学中心（UMMC）的114名长期感染HBV的成年人参加了这项研究。在每天饮用三杯或更多杯咖啡的人中观察到HBV DNA水平显着降低，中值降低523IU / mL（P = 0.003）。在每天饮用两杯的人中观察到HBsAg水平的降低，中值降低37IU / mL（P <0.001）。多变量分析显示，增加咖啡摄入量（P = 0.015）和降低ALT水平（P = 0.033）是降低HBV DNA水平的显着预测因子，而咖啡摄入量增加（P = 0.002）且有HBV感染家族史（ P = 0.021）是HBsAg水平较低的重要预测因子。这些数据表明，每天喝三杯或更多咖啡会降低循环HBV DNA和HBsAg水平。
关键词：

抗病毒;咖啡;乙型肝炎病毒;表面抗原;病毒载量

结论：
    31480588
DOI：
    10.3390 / v11090808

StephenW

https://www.mdpi.com/1999-4915/11/9/808/pdf