乙型肝炎核心抗体基线水平预测丙型肝炎转氨酶水平正常的HB

StephenW

Journal Summaries in Internal Medicine
Baseline level of hepatitis B core antibody predicts spontaneous hepatitis B e antigen (HBeAg) seroconversion in HBeAg-positive children with a normal alanine aminotransferase level

Hepatology — Chen HS, Wu JF, Su TH, et al. | August 14, 2019

In HBeAg-positive children with a normal alanine aminotransferase (ALT) level, baseline hepatitis B core antibody (anti-HBc) level was assessed as a predictor of spontaneous HBeAg seroconversion. Researchers longitudinally followed HBeAg-positive children with untreated chronic hepatitis B (CHB Using a double-sandwich immunoassay, they measured anti-HBc level. For a median of 19.8 years, they observed overall 182 children (106 males) with a median age of 10.6 years at study entry. Follow-up Revised the occurrence of spontaneous HBeAg seroconversion in 85 children (46.7%). According to multivariable survival analysis, spontaneous HBeAg seroconversion was predicted by a baseline anti-HBc titer of > 500 IU/mL, hepatitis B virus (HBV) genotype B and B + C, and a baseline hepatitis B surface antigen titer of ≤ 4.8 log10 IU/mL. In this patient population, baseline anti-HBc level was found to be predictive of spontaneous HBeAg seroconversion. In the HBeAg-positive no Rmal ALT phase of CHB, anti-HBV immune response was reflected by anti-HBc level.

Read the full article on Hepatology

StephenW

内科学杂志
乙型肝炎核心抗体基线水平预测丙型肝炎转氨酶水平正常的HBeAg阳性儿童自发性乙型肝炎e抗原（HBeAg）血清学转换

肝病学 - 陈HS，吴建福，苏TH，等。 | 2019年8月14日

在具有正常丙氨酸氨基转移酶（ALT）水平的HBeAg阳性儿童中，基线乙型肝炎核心抗体（抗-HBc）水平被评估为自发性HBeAg血清转换的预测因子。研究人员纵向跟踪HBeAg阳性儿童未治疗的慢性乙型肝炎（CHB使用双夹心免疫测定，他们测量抗HBc水平。中位数为19。8年，他们观察到总共182名儿童（106名男性），中位年龄为10.6岁。随访修订85例儿童自发性HBeAg血清学转换的发生率（46.7％）。根据多变量生存分析，基线抗HBc滴度> 500 IU / mL，乙型肝炎可预测自发性HBeAg血清学转换。病毒（HBV）基因型B和B + C，基线乙型肝炎表面抗原滴度≤4.8log10 IU / mL。在该患者人群中，基线抗HBc水平被发现可预测自发性HBeAg血清转换。在HBeAg中 - 阳性没有CHB的RAL ALT期，抗-HBc水平反映了抗HBV免疫应答。

阅读关于肝脏病学的完整文章

StephenW

https://aasldpubs.onlinelibrary. ... pT3rWyBcBd7Sg%3D%3D