血清阴性青年需要乙型肝炎再次接种的剂量，以抗乙型肝炎

StephenW

Fam Pract. 2019 Aug 3. pii: cmz039. doi: 10.1093/fampra/cmz039. [Epub ahead of print]
Doses of hepatitis B revaccination needed for the seronegative youths to be seropositive to antibody against hepatitis B surface antigen.
Jan CF1,2, Liu TH1, Ho CH1, Chien YC3, Chang CJ1, Guo FR1, Huang KC1,2.
Author information

1
    Department of Family Medicine, National Taiwan University Hospital, Taipei, Taiwan.
2
    Department of Family Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
3
    Genomics Research Center, Academia Sinica, Taipei, Taiwan.

Abstract
OBJECTIVES:

To determine the required hepatitis B vaccine doses for subjects who were seronegative for three hepatitis B seromarkers during their youth who wish to have seroprotective antibodies against the hepatitis B surface antigen (anti-HBs).
METHODS:

We conducted a retrospective cohort study. From 2012 to 2015, graduate school students born after 1986 who were seronegative for three hepatitis B virus seromarkers at college entrance (n = 1037) were recruited. Four groups of subjects received zero to three doses of a hepatitis B vaccine booster at their free willingness, and their anti-HBs titre were measured at their graduate school entrance. Very low and extremely low antibody titres against the hepatitis B surface antigen were elucidated by graphic inference to determine the required booster dose cut-off value for seropositivity after revaccination.
RESULTS:

The anti-HBs seropositive rates in the four groups of subjects receiving the hepatitis B booster vaccine(s) were 17.7%, 52.1%, 78.6% and 90.9% for those receiving zero, one, two and three doses, respectively. In subjects with very low antibody titres against the hepatitis B surface antigen after one dose of the vaccine booster and subjects with an extremely low titre after two doses of the booster, the seropositive rates reached 95% at the cut-off value of 3 mIU/ml.
CONCLUSION:

A seropositive rate of at least 95% can be reached by the administration of two hepatitis B booster doses to youths with extremely low antibody titres against the hepatitis B surface antigen (<3 mIU/ml) and administering one dose to those with very low titres (3-10 mIU/ml) at college.

© The Author(s) 2019. Published by Oxford University Press.
KEYWORDS:

Adolescent medicine; hepatology; immunization; prevention; primary care; public health

PMID:
    31375819
DOI:
    10.1093/fampra/cmz039

StephenW

Fam Pract。 2019年8月3日.pii：cmz039。 doi：10.1093 / fampra / cmz039。 [印刷前的电子版]
血清阴性青年需要乙型肝炎再次接种的剂量，以抗乙型肝炎表面抗原的血清阳性。
Jan CF1,2，Liu TH1，Ho CH1，Chien YC3，Chang CJ1，Guo FR1，Huang KC1,2。
作者信息

1
    台湾台北大学医院家庭医学系。
2
    台湾台北大学医学院家庭医学系。
3
    中国科学院基因组学研究中心，台湾台北。

抽象
目的：

为年龄较小的三种乙型肝炎血清标志物血清阴性的受试者确定所需的乙型肝炎疫苗剂量，这些受试者希望获得针对乙型肝炎表面抗原（抗-HBs）的血清保护性抗体。
方法：

我们进行了一项回顾性队列研究。从2012年到2015年，招募了1986年以后出生的研究生，他们在大学入口（n = 1037）为三种乙型肝炎病毒血清标记物血清阴性。四组受试者以自由意愿接受零至三剂乙肝疫苗加强剂，并且在他们的研究生入口处测量他们的抗HBs滴度。通过图解推断阐明了针对乙型肝炎表面抗原的非常低和极低的抗体滴度，以确定再次接种后血清阳性所需的加强剂量截止值。
结果：

接受乙肝加强疫苗接种的四组受试者的抗HBs血清阳性率分别为零，一，二和三剂量的17.7％，52.1％，78.6％和90.9％。在一剂疫苗加强剂和两剂加强剂后滴度极低的受试者抗乙型肝炎表面抗原滴度非常低的受试者中，血清阳性率达到95％，截止值为3 mIU /毫升。
结论：

对抗乙型肝炎表面抗原（<3 mIU / ml）抗体滴度极低且对滴度极低的青少年给予两次乙型肝炎加强剂量，可达到至少95％的血清阳性率（3-10 mIU / ml）在大学。

©The Author（s）2019。由牛津大学出版社出版。
关键词：

青少年医学;肝病;免疫接种;预防;初级卫生保健;公共卫生

结论：
    31375819
DOI：
    10.1093 / fampra / cmz039

StephenW

https://academic.oup.com/fampra/ ... mpra/cmz039/5543276