慢性乙型肝炎感染相关性肝病的免疫抑制：综述。

StephenW

World J Gastroenterol. 2019 Jul 21;25(27):3527-3537. doi: 10.3748/wjg.v25.i27.3527.
Immune suppression in chronic hepatitis B infection associated liver disease: A review.
Li TY1, Yang Y2, Zhou G1, Tu ZK3.
Author information

1
    Infectious Disease, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, Guangdong Province, China.
2
    Institute of Liver diseases, the First Hospital of Jilin University, Changchun 130061, Jilin Province, China.
3
    Infectious Disease, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, Guangdong Province, China. [email protected].

Abstract

Hepatitis B virus (HBV) infection is one the leading risk factors for chronic hepatitis, liver fibrosis, cirrhosis and hepatocellular cancer (HCC), which are a major global health problem. A large number of clinical studies have shown that chronic HBV persistent infection causes the dysfunction of innate and adaptive immune response involving monocytes/macrophages, dendritic cells, natural killer (NK) cells, T cells. Among these immune cells, cell subsets with suppressive features have been recognized such as myeloid derived suppressive cells(MDSC), NK-reg, T-reg, which represent a critical regulatory system during liver fibrogenesis or tumourigenesis. However, the mechanisms that link HBV-induced immune dysfunction and HBV-related liver diseases are not understood. In this review we summarize the recent studies on innate and adaptive immune cell dysfunction in chronic HBV infection, liver fibrosis, cirrhosis, and HCC, and further discuss the potential mechanism of HBV-induced immunosuppressive cascade in HBV infection and consequences. It is hoped that this article will help ongoing research about the pathogenesis of HBV-related hepatic fibrosis and HBV-related HCC.
KEYWORDS:

Dendritic cells; Hepatitis B virus; Hepatocellular carcinoma; Liver fibrosis; Monocytes; Regulatory T cells; Regulatory natural killer cells

PMID:
    31367154
PMCID:
    PMC6658392
DOI:
    10.3748/wjg.v25.i27.3527

StephenW

World J Gastroenterol。 2019年7月21日; 25（27）：3527-3537。 doi：10.3748 / wjg.v25.i27.3527。
慢性乙型肝炎感染相关性肝病的免疫抑制：综述。
Li TY1，Yang Y2，Zhou G1，Tu ZK3。
作者信息

1
    广州医科大学附属第二医院传染病研究室，广东省广州市510000
2
    吉林大学第一医院肝病研究所，吉林省长春130061
3
    广州医科大学附属第二医院传染病研究室，广东省广州市510000 [email protected]。

抽象

乙型肝炎病毒（HBV）感染是慢性肝炎，肝纤维化，肝硬化和肝细胞癌（HCC）的主要危险因素之一，这是一个主要的全球健康问题。大量临床研究表明，慢性HBV持续感染引起先天性和适应性免疫应答的功能障碍，涉及单核细胞/巨噬细胞，树突细胞，自然杀伤（NK）细胞，T细胞。在这些免疫细胞中，已经认识到具有抑制特征的细胞亚群，例如髓源性抑制细胞（MDSC），NK-reg，T-reg，其代表肝纤维发生或肿瘤发生过程中的关键调节系统。然而，关联HBV诱导的免疫功能障碍和HBV相关肝病的机制尚不清楚。在这篇综述中，我们总结了最近关于慢性HBV感染，肝纤维化，肝硬化和HCC中先天性和适应性免疫细胞功能障碍的研究，并进一步讨论了HBV诱导的免疫抑制级联在HBV感染中的潜在机制及其后果。希望本文将有助于正在进行的关于HBV相关性肝纤维化和HBV相关性HCC发病机制的研究。
关键词：

树突状细胞;乙型肝炎病毒;肝细胞癌;肝纤维化;单核细胞;调节性T细胞;监管自然杀手细胞

结论：
    31367154
PMCID：
    PMC6658392
DOI：
    10.3748 / wjg.v25.i27.3527

StephenW

https://www.wjgnet.com/1007-9327/full/v25/i27/3527.htm