慢性乙型肝炎患者的疲劳是显着的并且与自主神经功能障碍

StephenW

Health Qual Life Outcomes. 2019 Jul 25;17(1):130. doi: 10.1186/s12955-019-1200-3.
Fatigue in chronic hepatitis B patients is significant and associates with autonomic dysfunction.
Wang H1, Zhou Y2, Yan R2, Ru GQ3, Yu LL3, Yao J2,4.
Author information

1
    Department of Infectious Diseases, Zhejiang Provincial People's Hospital, People's Hospital Hang Zhou Medical College, 108, Shan Tang Road, Hangzhou, 310016, Zhejiang Province, China. [email protected].
2
    Department of Infectious Diseases, Zhejiang Provincial People's Hospital, People's Hospital Hang Zhou Medical College, 108, Shan Tang Road, Hangzhou, 310016, Zhejiang Province, China.
3
    Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital Hang Zhou Medical College, Zhejiang, China.
4
    Department of Medical Record Statistic Information, Zhejiang Provincial People's Hospital, People's Hospital Hang Zhou Medical College, Zhejiang, China.

Abstract
BACKGROUND:

Fatigue is an important clinical finding in patients with chronic hepatitis virus infection. However, studies assessing fatigue in patients with chronic hepatitis B (CHB) are very limited. This study aimed to quantify the severity of fatigue in patients with CHB, to determine whether perceived fatigue reflects impairment of functional ability, and to explore potential causes.
METHODS:

A total of 133 patients with histologically proven CHB and 59 community controls were assessed using the fatigue impact scale (FIS).
RESULTS:

The degree of fatigue was significantly higher in patients with CHB than in controls (mean (range) FIS 24.9 (0-91) vs. 15.7 (0-31), p < 0.001). Fatigue experienced by patients with CHB was similar to that in primary biliary cirrhosis (PBC) (n = 20) (FIS 22.2 vs. 20.9, p = 0.28). No association was found between FIS and biochemistry and histological parameters of liver disease severity. Significant associations were found between fatigue severity and cognitive impairment (r = 0.39, p < 0.001), daytime somnolence (r = 0.32, p < 0.001), scores of the Chronic Liver Disease Questionnaire (r = - 0.31, p < 0.001), and autonomic symptoms (r = 0.43, p < 0.001). The level of autonomic symptom was the only factor independently associated with the degree of fatigue.
CONCLUSION:

Fatigue is a significant problem of functional ability impairment in CHB and similar in degree to that in PBC patients. Fatigue in patients with CHB appears to be unrelated to the severity of liver disease but is associated with significant autonomic symptoms.
KEYWORDS:

Autonomic; Fatigue; HBV; Symptom

PMID:
    31345232
DOI:
    10.1186/s12955-019-1200-3

StephenW

健康质量生活结果。 2019年7月25日; 17（1）：130。 doi：10.1186 / s12955-019-1200-3。
慢性乙型肝炎患者的疲劳是显着的并且与自主神经功能障碍相关。
Wang H1，Zhou Y2，Yan R2，Ru GQ3，Yu LL3，Yao J2,4。
作者信息

1
杭州市山塘路108号杭州医学院人民医院浙江省人民医院感染科，浙江省杭州市310016 [email protected]。
2
杭州市山塘路108号杭州医学院人民医院浙江省人民医院感染科，浙江省杭州市310016
3
浙江省人民医院病理科，杭州医学院人民医院，浙江杭州
4
浙江省人民医院浙江省人民医院病历统计信息部，杭州医学院，浙江省人民医院

抽象
背景：

评估慢性乙型肝炎（CHB）患者疲劳的评估非常有限。本研究旨在量化CHB患者疲劳的严重程度，以确定感知疲劳是否满足功能障碍，并探讨潜在原因。
方法：

使用疲劳影响量表（FIS）评估总共133名经组织学证实的CHB患者和59名社区对照。
结果：

CHB患者的疲劳程度显着高于对照组（平均值（范围）FIS 24.9（0-91）vs。15.7（0-31），p <0.001）。 CHB患者的疲劳与原发性胆汁性肝硬化（PBC）（n = 20）相似（FIS 22.2 vs. 20.9，p = 0.28）。 FIS与肝病严重程度的生化和组织学参数之间未发现相关性。疲劳严重和认知障碍（r = 0.39，p <0.001），白天嗜睡（r = 0.32，p <0.001），慢性肝病问卷评分（r =  -  0.31，p <0.001）之间存在显着相关性，和自主神经症状（r = 0.43，p <0.001）。自主神经症状的水平是与疲劳程度独立相关的唯一因素。
结论：

疲劳是CHB中潜在能力损害的重要问题，并且与PBC患者的程度相似。 CHB患者的疲劳似乎与肝病的严重程度无关，但与显着的自主神经有关。
关键词：

自主;疲劳; HBV;症状

结论：
31345232
DOI：
10.1186 / s12955-019-1200-3

StephenW

https://hqlo.biomedcentral.com/t ... 6/s12955-019-1200-3