ShearWave Elastography预测慢性肝病的死亡率

StephenW

ShearWave Elastography predicts mortality in chronic liver disease
July 25, 2019

Liver stiffness measured by 2D ShearWave Elastography demonstrated significant predictive value in the progression of chronic liver disease including associated complications and mortality, according to a press release from SuperSonic Imagine and a poster presented at the International Liver Congress 2019.

ShearWave Elastography (SWE) provides a quantitative color-coded map that visualizes and quantifies tissue stiffness during examination displayed in kilopascals.

“Recognizing the high diagnostic value of its biomarker in the prediction of survival, SuperSonic Imagine has taken a new step towards earlier and better-adapted patient management,” Michèle Lesieur, CEO of SuperSonic Imagine, said in the release. “This study not only confirms the expertise of SuperSonic Imagine in the evaluation of liver disease, but also the diagnostic benefits of its ultrasound innovations. To date, over 160 clinical articles have been published on the use of ShearWave Elastography in patients with liver disease.”

The multicenter study comprised 1,434 patients with chronic liver disease without decompensation. The AUC of SWE for mortality within 24 months was 0.815 (95% CI, 0.773-0.857) with a cut-off of 20.6 kPa (sensitivity, 76%; specificity, 80%).

Multivariate analysis revealed that a measurement less than 20.6 kPa correlated independently with overall mortality (HR = 2.17; 95% CI, 0.99-4.76), besides albumin (HR = 0.93; 95% CI, 0.89-0.978), MELD (HR = 1.08; 95% CI, 1.013-1.146) and age (HR = 1.01; 95% CI, 1.007-1.065).

“As a hepatologist, I can say that the number of patients with chronic liver disease is constantly increasing, and that it’s becoming ever more vital for physicians, radiologists and hepatologists, to have reliable tools such as SWE to address this major public health problem in the most effective way,” Jonel Trebicka, MD, PhD, from the University Clinic of Frankfurt in Germany, and lead study author, said in the release. “This study has allowed us to establish a new threshold value to help predict outcomes for each patient. Patients reaching more than 20.6 kPa are at two-fold higher risk of death within one year. This is important because it can be used as a biomarker to stratify care in patients with cirrhosis.”

Reference: www.supersonicimagine.com

StephenW

ShearWave Elastography预测慢性肝病的死亡率
2019年7月25日

根据SuperSonic Imagine的新闻稿和2019年国际肝病大会上发表的一张海报，通过2D ShearWave Elastography测量的肝硬度证明了慢性肝病进展中的显着预测价值，包括相关的并发症和死亡率。

ShearWave Elastography（SWE）提供了一种定量的彩色编码图，可以在以千帕为单位显示的检查过程中可视化和量化组织硬度。

SuperSonic Imagine首席执行官MichèleLesieur在发布会上表示，“认识到其生物标志物在预测生存方面具有很高的诊断价值，SuperSonic Imagine在早期和更好地适应患者管理方面迈出了新的一步。” “这项研究不仅证实了SuperSonic Imagine在评估肝脏疾病方面的专业知识，而且还证实了其超声波创新的诊断益处。迄今为止，已发表了160多篇关于在肝病患者中使用ShearWave弹性成像的临床文章。 “

该多中心研究汇编了1,434例无失代偿的慢性肝病患者。 SWE在24个月内死亡率的AUC为0.815（95％CI，0.773-0.857），截止值为20.6 kPa（敏感性，76％;特异性，80％）。

多变量分析显示，除白蛋白外，小于20.6 kPa的测量值与总死亡率（HR = 2.17; 95％CI，0.99-4.76）无关（HR = 0.93; 95％CI，0.89-0.978），MELD（HR = 1.08） ）95％CI，1.013-1.146）和年龄（HR = 1.01; 95％CI，1.007-1.065）。

“作为一名肝病专家，我可以说慢性肝病患者的数量在不断增加，而且对于医生，放射科医生和肝病专家来说，拥有可靠的工具如SWE来解决这一重大公共卫生问题变得越来越重要。最有效的方式，“来自德国法兰克福大学诊所的医学博士Jonel Trebicka和首席研究作者，在发布会上说。 “这项研究使我们能够建立一个新的阈值来帮助预测每位患者的预后。达到20.6 kPa以上的患者在一年内死亡的风险增加了两倍。这很重要，因为它可以用作生物标志物对肝硬化患者的护理进行分层。“

参考：www.supersonicimagine.com