肝癌家族史可能会改变中国人群中HBV感染与肝癌的关系。

StephenW

Liver Int. 2019 Jun 22. doi: 10.1111/liv.14182. [Epub ahead of print]
Family History of Liver Cancer May Modify the Association between HBV Infection and Liver Cancer in a Chinese Population.
Liu X1,2, Baecker A1, Wu M3, Zhou JY3, Yang J3, Han RQ3, Wang PH3, Jin ZY2, Liu AM4, Gu X4, Zhang XF5, Wang XS5, Su M6, Hu X6, Sun Z7, Li G7, Fu A1, Jung SY8,9, Mu L10, He N2, Li L11, Zhao JK3, Zhang ZF1,8,12.
Author information

1
    Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, 90095.
2
    Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China, 200032.
3
    Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China, 210009.
4
    Dafeng Center for Disease Control and Prevention, Dafeng, Jiangsu, China, 224100.
5
    Ganyu Center for Disease Control and Prevention, Ganyu, Jiangsu, China, 222003.
6
    Chuzhou County Center for Disease Control and Prevention, Chuzhou, Jiangsu, China, 223001.
7
    Tongshan County Center for Disease control and Prevention, Tongshan, Jiangsu, China, 221006.
8
    Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, 90095-1781, USA.
9
    School of Nursing, UCLA, Los Angeles, CA, 90095, USA.
10
    Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, NY, 14214.
11
    Department of Epidemiology, School of Public Health, Peking University, Beijing, China, 100083.
12
    David Geffen School of Medicine, Center for Human Nutrition, UCLA, Los Angeles, CA, 90095, USA.

Abstract
BACKGROUND & AIMS:

The potential interaction between family history of liver cancer and HBV infection on liver cancer has not been fully examined.
METHODS:

We conducted a population-based case-control study composed of 2,011 liver cancer cases and 7,933 controls in Jiangsu province, China from 2003 to 2010. Data on major risk or protective factors were collected and HBV/HCV sero-markers were assayed using blood samples. Semi-Bayes (SB) adjustments were applied to provide posterior estimates.
RESULTS:

Both family history of liver cancer (adjusted OR: 4.32, 95% CI: 3.25-5.73) and HBsAg positivity (adjusted OR: 9.94, 95% CI: 8.33-11.87) were strongly associated with liver cancer development. For individuals with different combinations of serological markers, the adjusted ORs were 8.45 (95% CI: 5.16-13.82) for HBsAg and HBcAb positive; 7.57 (95% CI: 4.87-11.77) for HBsAg, HBeAg and HBcAb positive; and 3.62 (95% CI: 2.47-5.31) for HBsAg, HBeAb and HBcAb positive, compared to all negatives in HBV serological markers. One log increase in HBV DNA level was associated with 17% increased risk (adjusted OR: 1.17, 95% CI: 1.03-1.32). The SB-adjusted OR of HBV-positive individuals with family history of liver cancer was 41.34 (95% posterior interval [PI]: 23.69-72.12) compared with those HBV-negative without family history. Relative excess risk due to additive interaction, the attributable proportion and synergy index were 73.13, 0.87 and 8.04, respectively. Adjusted ratio of odds ratios for multiplicative interaction was 2.84 (95% CI: 1.41-5.75).
CONCLUSIONS:

Super-additive and super-multiplicative interactions may exist between family history of liver cancer and HBV infection on the development of liver cancer. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.
KEYWORDS:

Family history; Hepatitis B Virus; Hepatocellular carcinoma; Interaction; Serological marker

PMID:
    31228882
DOI:
    10.1111/liv.14182

StephenW

肝脏国际2019年6月22日doi：10.1111 / liv.14182。 [印刷前的电子版]
肝癌家族史可能会改变中国人群中HBV感染与肝癌的关系。
Liu X1,2，Baecker A1，Wu M3，Zhou JY3，Yang J3，Han RQ3，Wang PH3，Jin ZY2，Liu AM4，Gu X4，Zhang XF5，Wang XS5，Su M6，Hu X6，Sun Z7，Li G7， Fu A1，Jung SY8,9，Mu L10，He N2，Li L11，Zhao JK3，Zhang ZF1,8,12。
作者信息

1
    加利福尼亚大学洛杉矶分校公共卫生学院流行病学系，90095。
2
    复旦大学公共卫生学院流行病学系，上海200032
3
    江苏省疾病预防控制中心，江苏南京210009。
4
    大丰市疾病预防控制中心，江苏大丰，224100。
五
    中国江苏赣榆赣榆疾病预防控制中心，222003。
6
    滁州县疾病预防控制中心，江苏滁州223001。
7
    铜山县疾病预防控制中心，江苏铜山221006。
8
    Jonsson Comprehensive Cancer Center，UCLA，Los Angeles，CA，90095-1781，USA。
9
    加州大学洛杉矶分校护理学院，洛杉矶，加利福尼亚州，90095，美国。
10
    纽约州立大学布法罗分校公共卫生与健康专业学院流行病学与环境卫生系，纽约州布法罗，14214。
11
    北京大学公共卫生学院流行病学系，北京100083
12
    David Geffen医学院，人类营养中心，加州大学洛杉矶分校，洛杉矶，加利福尼亚州，90095，美国。

抽象
背景与目的：

尚未充分研究肝癌家族史与肝癌HBV感染之间的潜在相互作用。
方法：

我们在2003年至2010年期间进行了一项基于人群的病例对照研究，该研究由中国江苏省的2,011例肝癌病例和7,933例对照组成。收集主要风险或保护因素的数据，并使用血液样本检测HBV / HCV血清标记物。应用半贝叶斯（SB）调整来提供后验估计。
结果：

肝癌家族史（校正OR：4.32,95％CI：3.25-5.73）和HBsAg阳性（校正OR：9.94,95％CI：8.33-11.87）与肝癌发展密切相关。对于具有不同血清学标志物组合的个体，HBsAg和HBcAb阳性的调整OR值为8.45（95％CI：5.16-13.82）; HBsAg，HBeAg和HBcAb阳性7.57（95％CI：4.87-11.77）;与HBV血清学标志物中的所有阴性相比，HBsAg，HBeAb和HBcAb阳性为3.62（95％CI：2.47-5.31）。 HBV DNA水平增加一个百分点与风险增加17％相关（调整OR：1.17,95％CI：1.03-1.32）。与没有家族史的HBV阴性患者相比，具有肝癌家族史的HBV阳性个体的SB调整OR为41.34（95％后区间[PI]：23.69-72.12）。加性相互作用引起的相对超额风险，归因比例和协同指数分别为73.13,0.87和8.04。乘法相互作用的比值比的调整比率为2.84（95％CI：1.41-5.75）。
结论：

肝癌家族史与HBV感染之间可能存在超加性和超乘性相互作用对肝癌的发展。本文受版权保护。版权所有。

本文受版权保护。版权所有。
关键词：

家史;乙型肝炎病毒;肝细胞癌;相互作用;血清学标志物

结论：
    31228882
DOI：
    10.1111 / liv.14182