基线抗HBc水平可预测自发性HBeAg血清转换

StephenW

Baseline Anti-HBc Level Is Predictive of Spontaneous HBeAg Seroconversion
Virginia Schad, PharmD
The baseline hepatitis B core antibody (anti-HBc) level is predictive of spontaneous hepatitis B e antigen (HBeAg) seroconversion in HBeAg-positive children with a normal alanine aminotransferase (ALT) level, according to a longitudinal study published in Hepatology.1

Anti-HBc is a sensitive marker of hepatitis B virus (HBV) infection, and baseline anti-HBc levels are predictive of HBeAg seroconversion in adults with chronic hepatitis B (CHB) treated with peg-interferon or nucleotide analogues.2-4 While anti-HBc is a biomarker of hepatic inflammation in adults with CHB and a normal ALT level,5 few studies have focused on anti-HBc levels in children and whether baseline anti-HBc levels in HBeAg-positive children with CHB and a normal ALT level is predictive of HBeAg seroconversion. Therefore, researchers investigated the correlation between anti-HBc level and the natural course of CHB infection in children, particularly the ability of the baseline anti-HBc level to predict spontaneous HBeAg seroconversion during long-term follow-up.1 They followed 182 children for a median of 19.8 years and found that spontaneous HBeAg seroconversion occurred in 85 children (46.7%). A baseline anti-HBc titer of >500 IU/mL, HBV genotype B and B+C, and a baseline hepatitis B surface antigen titer of ≤4.8 log10 IU/mL were predictive of spontaneous HBeAg seroconversion. In children that remained HBeAg positive, anti-HBc levels gradually increased because of ongoing inflammation.

The authors concluded that, “The baseline anti-HBc level is predictive of spontaneous HBeAg seroconversion in HBeAg-positive children with a normal ALT level.”1 They added that, “The anti-HBc level reflects anti-HBV immune response in the HBeAg-positive normal ALT phase of CHB.”


References
1. Chen HS, Wu JF, Su TH, et al. Baseline level of hepatitis B core antibody predicts spontaneous HBeAg seroconversion in HBeAg-positive children with a normal ALT level [published online May 23, 2019]. Hepatology. doi:10.1002/hep.30788.

StephenW

基线抗HBc水平可预测自发性HBeAg血清转换
Virginia Schad，PharmD
根据Hepatology发表的一项纵向研究，基线乙型肝炎核心抗体（抗-HBc）水平可预测HBeAg阳性儿童的自发性乙型肝炎e抗原（HBeAg）血清转换水平正常丙氨酸氨基转移酶（ALT）水平。

抗-HBc是乙型肝炎病毒（HBV）感染的敏感标志物，基线抗-HBc水平可预测用peg-干扰素或核苷酸类似物治疗的慢性乙型肝炎（CHB）成人的HBeAg血清学转换.2-4 -HBc是CHB成人和正常ALT水平的成人肝脏炎症的生物标志物，很少有研究关注儿童的抗HBc水平以及HBeAg阳性的CHB和ALT水平正常儿童的基线抗HBc水平是否为预测HBeAg血清学转换。因此，研究人员调查了抗HBc水平与儿童CHB感染的自然过程之间的相关性，特别是基线抗HBc水平在长期随访期间预测自发性HBeAg血清转换的能力.1他们追踪了182名儿童中位数为19.8岁，发现自发性HBeAg血清学转换发生在85名儿童（46.7％）。基线抗HBc滴度> 500 IU / mL，HBV基因型B和B + C，基线乙型肝炎表面抗原滴度≤4.8log10IU / mL可预测自发性HBeAg血清转换。在HBeAg阳性的儿童中，由于持续发炎，抗-HBc水平逐渐升高。

作者得出结论：“基线抗-HBc水平可预测ALe水平正常的HBeAg阳性儿童自发性HBeAg血清转换。”1他们补充说，“抗-HBc水平反映了HBeAg中的抗HBV免疫反应” -CHB阳性正常ALT期。“


参考
1. Chen HS，Wu JF，Su TH，et al。乙型肝炎核心抗体的基线水平可预测ALT水平正常的HBeAg阳性儿童的自发性HBeAg血清转换[在线发表于2019年5月23日]。肝病。 DOI：10.1002 / hep.30788