产前使用乙型肝炎免疫球蛋白预防乙型肝炎病毒母婴传播的

StephenW

Efficacy of antepartum administration of hepatitis B immunoglobulin in preventing mother-to-child transmission of hepatitis B virus

Journal of Viral Hepatitis — Zhao M, et al. | June 18, 2019



Researchers investigated if antepartum administration of three doses of hepatitis B immunoglobulin (HBIG) is efficacious in interrupting mother-to-child transmission (MTCT) of hepatitis B virus (HBV). They enrolled 728 hepatitis B e antigen-positive pregnant women with chronic HBV infection who had an HBV DNA level higher than 6log10 copies/mL in this trial. Based on individual preference, three groups of patients were formed: Group A and group B received 200 IU (unit) HBIG and 400 IU (unit) HBIG intramuscularly once a month at the third, second and first month before delivery, respectively; Group C received no special treatment and served as the control. As per outcomes, the MTCT of HBV was effectively prevented with the administration of passive-active immunoprophylaxis to infants. They noted neither decrease in the rate of MTCT nor an increase in the antibody against hepatitis B surface antigen levels of infants born to hepatitis B surface antigen-positive mothers with HBV DNA higher than 6log10 copies/mL when extra antepartum administration of HBIG during pregnancy was performed.

StephenW

产前使用乙型肝炎免疫球蛋白预防乙型肝炎病毒母婴传播的疗效

病毒性肝炎杂志 - 赵默，等。 | 2019年6月18日


研究人员调查了产前给予三剂乙型肝炎免疫球蛋白（HBIG）是否有效中断乙型肝炎病毒（HBV）的母婴传播（MTCT）。他们招募了728名患有慢性HBV感染的乙型肝炎e抗原阳性孕妇，他们的HBV DNA水平高于6log10拷贝/ mL。根据个人偏好，形成三组患者：A组和B组分别在分娩前第3个月，第2个月和第1个月肌肉注射200 IU（单位）HBIG和400 IU（单位）HBIG; C组未接受特殊治疗，并作为对照组。根据结果​​，通过对婴儿施用被动 - 主动免疫预防可有效预防HBV的MTCT。他们指出，在HBV DNA高于6log10拷贝/ mL的乙型肝炎表面抗原阳性母亲所生的婴儿中，当怀孕期间额外产前给予HBIG时，MTCT率和抗乙型肝炎表面抗原水平的抗体均未增加。执行。