香港血源性及肠道病毒性肝炎的全港性流行病学研究

StephenW

A Territorywide Prevalence Study on Blood-Borne and Enteric Viral Hepatitis in Hong Kong
Kevin S H Liu Wai-Kay Seto Eric H Y Lau Danny Ka-Ho Wong Yuk-Fai Lam Ka-Shing Cheung Lung-Yi Mak Kwan-Lung Ko Wai-Pan To Mildred W K Law ... Show more
The Journal of Infectious Diseases, Volume 219, Issue 12, 15 June 2019, Pages 1924–1933, https://doi.org/10.1093/infdis/jiz038
Published:
21 January 2019
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Abstract
Background

Viral hepatitis epidemiological data are important for the World Health Organization plan of eliminating viral hepatitis. We aimed to document the prevalence of viral hepatitis A to E in Hong Kong.
Methods

This community-based study was open to all Hong Kong Chinese citizens aged ≥18 years. Baseline data and risk factors were collected. Hepatitis A–E serology was measured, including hepatitis B e antigen, antibodies to hepatitis B e antigen, antibodies to hepatitis D, hepatitis B virus (HBV) DNA for hepatitis B surface antigen (HBsAg)–positive participants, and antibodies to hepatitis B surface antigen and antibodies to hepatitis B core antigen (anti-HBc) in HBsAg-negative participants. Hepatitis C virus (HCV) RNA and genotypes were determined in anti-HCV–positive participants.
Results

A total of 10 256 participants were recruited from February 2015 to July 2016. Overall HBsAg seroprevalence was 7.8% (95% confidence interval [CI], 7.3%–8.3%), which was reduced significantly with HBV vaccination (odds ratio, 0.15 [95% CI, .11–.21]). Among HBsAg-negative participants, anti-HBc seroprevalence increased from 5.4% (<26 years) to 60.1% (>65 years). No hepatitis D virus (HDV) cases were detected. Anti-HCV positivity was 0.5% (95% CI, .3%–.6%). Prevalence of antibodies to hepatitis A virus (anti-HAV) and hepatitis E virus (anti-HEV) was 65.2% (95% CI, 64.2%–66.1%) and 33.3% (95% CI, 32.4%–34.2%), respectively, and were influenced by age, family income, and being born in mainland China.
Conclusions

HBV seroprevalence remained high despite universal vaccination. High anti-HBc seroprevalence underlines the potential issue of HBV reactivation during profound immunosuppression. HCV and HDV remained uncommon. Anti-HAV seroprevalence had decreased whereas anti-HEV seroprevalence had risen.
HBV, HCV, vaccination, immigration, HAV, HEV
Topic:

    hepatitis hepatitis a china hepatitis b e antigens hepatitis b surface antigens hepatitis c antibodies hepatitis e virus hong kong vaccination world health organization antibodies hepatitis a virus hepatitis b virus viral hepatitis hepatitis a virus antibodies hepatitis c virus hepatitis b core antibody community seroprevalence

Issue Section:
Viruses

StephenW

香港血源性及肠道病毒性肝炎的全港性流行病学研究
Kevin S H Liu Wai-Kay濑户Eric H Y Lau Danny Ka-Ho Wong Yuk-Fai Lam Ka-Shing Cheung Lung-Yi Mak Kwan-Lung Ko Wai-Pan To Mildred W K Law ...显示更多
Journal of Infectious Diseases，第219卷，第12期，2019年6月15日，第1924-1933页，https：//doi.org/10.1093/infdis/jiz038
发布时间：
2019年1月21日
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背景

病毒性肝炎流行病学数据对于世界卫生组织消除病毒性肝炎的计划非常重要。我们的目的是记录香港病毒性肝炎A至E的患病率。
方法

这项以社区为基础的研究向所有年龄≥18岁的香港中国公民开放。收集了基线数据和风险因素。测定甲型肝炎血清学，包括乙型肝炎e抗原，乙型肝炎e抗原抗体，丁型肝炎抗体，乙型肝炎病毒表面抗原（HBsAg）阳性参与者乙型肝炎病毒（HBV）DNA和乙型肝炎抗体表面抗原和HBsAg阴性参与者的乙型肝炎核心抗原（抗HBc）抗体。在抗HCV阳性参与者中测定丙型肝炎病毒（HCV）RNA和基因型。
结果

2015年2月至2016年7月共招募了10 256名参与者。总体HBsAg血清阳性率为7.8％（95％置信区间[CI]，7.3％-8.3％），HBV疫苗接种率显着降低（优势比，0.15 [ 95％CI，.11-.21]）。在HBsAg阴性参与者中，抗HBc血清阳性率从5.4％（<26岁）增加到60.1％（> 65岁）。未检测到丁型肝炎病毒（HDV）病例抗-HCV阳性率为0.5％（95％CI，。3％ - 。6％）。甲型肝炎病毒（抗-HAV）和戊型肝炎病毒（抗-HEV）抗体的患病率为65.2％（95％CI，64.2％-66.1％）和33.3％（95％CI，32.4％-34.2％），分别受年龄，家庭收入和出生在中国大陆的影响。
结论

尽管普遍接种疫苗，HBV血清阳性率仍然很高。高抗HBc血清阳性率突显了在严重免疫抑制期间HBV再激活的潜在问题。 HCV和HDV仍然不常见。抗-HV血清阳性率从抗HEV血清阳性率上升后下降。
HBV，HCV，疫苗接种，移民，HAV，HEV
话题：

中国肝炎2005年b抗原乙型肝炎表面抗原丙型肝炎抗体肝炎病毒香港疫苗接种世界卫生组织抗体甲型肝炎病毒乙型肝炎病毒病毒性肝炎病毒抗体丙型肝炎病毒乙型肝炎核心抗体社区血清阳性率

问题部分：
病毒