年龄，种族和病毒基因型与慢性乙型肝炎患儿和成人乙型肝

StephenW

J Viral Hepat. 2019 Apr 11. doi: 10.1111/jvh.13104. [Epub ahead of print]
Age, race and viral genotype are associated with the prevalence of Hepatitis B e antigen in children and adults with chronic Hepatitis B.
Di Bisceglie AM1, King WC2, Lisker-Melman M3, Khalili M4, Belle SH2, Feld JJ5, Ghany MG6, Janssen HLA5, Lau D7, Lee WM8, Ling SC5, Cooper S9, Rosenthal P4, Schwarz KB10, Sterling RK11, Teckman JH1, Terrault N4; Hepatitis B Research Network (HBRN).
Collaborators (37)

Chung RT, Roberts LR, Hassan MA, Schwarzenberg SJ, Wong DK, Juan J, Yim C, Patel K, Murakami CS, Perrillo R, Do S, Rodriguez-Baez N, Han SB, Tran TT, Cooper SL, Lok AS, Fontana RJ, Tsai N, Younoszai B, Fried MW, Muir A, Evon D, Darling JM, Carithers RC, Shuhart M, Kowdley KV, Wang CC, Murray KF, Luketic VA, Jake Liang T, Hoofnagle JH, Doo E, Chang KM, Park JJ, Wahed A, Cloonan Y, Kleiner D.
Author information

1
    Saint Louis University Liver Center, Saint Louis University.
2
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh.
3
    Washington University.
4
    University of California at San Francisco.
5
    Toronto Centre for Liver Disease, Toronto General Hospital, University of Toronto.
6
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases.
7
    Beth Israel, Deaconess Medical Center.
8
    University of Texas, Southwestern Medical Center.
9
    California Pacific Medical Center.
10
    Johns Hopkins University School of Medicine.
11
    Virginia Commonwealth University.

Abstract

Hepatitis B e antigen (HBeAg) is an important serological marker of hepatitis B virus (HBV) infection and is associated with higher levels of viremia, increased risk of infectivity to others and increased risk of hepatocellular carcinoma. We analyzed HBeAg status in a large cohort of adults and children enrolled in Cohort Studies of the Hepatitis B Research Network, long-term natural history studies of chronic HBV infection. A cross sectional analysis examined factors associated with HBeAg positivity, including demographic and virologic data, across the age spectrum. Among 2,241 enrolled participants who met criteria for this analysis, 825 (37%) were seropositive for HBeAg. The prevalence of HBeAg was lower in those with older age, ranging from 85% among up to 10 years of age to only 12% among those older than 50 years. In addition to age, both race and HBV genotype were independently associated with HBeAg positivity. There was a significant interaction between age and race; prevalence of HBeAg was significantly higher among Asians >10-30 years old vs. whites or blacks who were >10 to 30 years old, and those infected with HBV genotype C. Conversely, the presence of the basal core promoter and pre-core variants were associated with significantly lower prevalence of HBeAg, even when adjusted for age, race and genotype. These data will provide a better understanding of factors associated with seropositivity for HBeAg and may lead to better strategies for preventing HBV infection and broader indications for antiviral therapy. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.
KEYWORDS:

e antigen; hepatitis B; natural history

PMID:
    30974509
DOI:
    10.1111/jvh.13104

StephenW

J病毒肝病。 2019年4月11日doi：10.1111 / jvh.13104。 [印刷前的电子版]
年龄，种族和病毒基因型与慢性乙型肝炎患儿和成人乙型肝炎e抗原的患病率相关。
Di Bisceglie AM1，King WC2，Lisker-Melman M3，Khalili M4，Belle SH2，Feld JJ5，Ghany MG6，Janssen HLA5，Lau D7，Lee WM8，Ling SC5，Cooper S9，Rosenthal P4，Schwarz KB10，Sterling RK11，Teckman JH1 ，Terrault N4;乙型肝炎研究网络（HBRN）。
合作者（37）

Chung RT，Roberts LR，Hassan MA，Schwarzenberg SJ，Wong DK，Juan J，Yim C，Patel K，Murakami CS，Perrillo R，Do S，Rodriguez-Baez N，Han SB，Tran TT，Cooper SL，Lok AS， Fontana RJ，Tsai N，Younoszai B，Fried MW，Muir A，Evon D，Darling JM，Carithers RC，Shuhart M，Kowdley KV，Wang CC，Murray KF，Luketic VA，Jake Liang T，Hoofnagle JH，Doo E，Chang KM，Park JJ，Wahed A，Cloonan Y，Kleiner D.
作者信息

1
    圣路易斯大学肝脏中心，圣路易斯大学。
2
    匹兹堡大学公共卫生研究生院流行病学系。
3
    华盛顿大学。
4
    加州大学旧金山分校。
五
    多伦多大学多伦多综合医院多伦多肝病中心。
6
    国家糖尿病与消化和肾脏疾病研究所肝病科。
7
    Beth Israel，Deaconess医疗中心。
8
    德克萨斯大学西南医学中心。
9
    加州太平洋医疗中心。
10
    约翰霍普金斯大学医学院。
11
    弗吉尼亚联邦大学。

抽象

乙型肝炎e抗原（HBeAg）是乙型肝炎病毒（HBV）感染的重要血清学标志物，并且与更高水平的病毒血症，增加的感染风险和增加的肝细胞癌风险相关。我们分析了一大群成人和儿童的HBeAg状态，这些成人和儿童参加了乙型肝炎研究网络的队列研究，这是慢性HBV感染的长期自然史研究。横断面分析检查了与年龄范围内HBeAg阳性相关的因素，包括人口统计学和病毒学数据。在符合该分析标准的2,241名登记参与者中，825名（37％）为HBeAg血清反应阳性。 HBeAg的患病率在年龄较大的患者中较低，从10岁至85岁不等，在50岁以上的患者中仅为12％。除年龄外，种族和HBV基因型均与HBeAg阳性独立相关。年龄和种族之间存在显着的相互作用;在> 10-30岁的亚洲人中，HBeAg的患病率显着高于> 10至30岁的白人或黑人，以及感染HBV基因型C的人。相反，基础核心启动子和前核心变体的存在即使根据年龄，种族和基因型进行调整，HBeAg的患病率也显着降低。这些数据将更好地了解与HBeAg血清阳性相关的因素，并可能导致更好的预防HBV感染的策略和更广泛的抗病毒治疗适应症。本文受版权保护。版权所有。

本文受版权保护。版权所有。
关键词：

e抗原;乙型肝炎;自然历史

结论：
    30974509
DOI：
    10.1111 / jvh.13104