抑郁和失眠与慢性乙型肝炎的甲状腺激素水平密切相关。

StephenW

Med Sci Monit. 2019 Apr 11;25:2672-2678. doi: 10.12659/MSM.914444.
Depression and Insomnia Are Closely Associated with Thyroid Hormone Levels in Chronic Hepatitis B.
Huang X1, Zhang H2, Qu C3, Liu Y1, Bian C1, Xu Y2.
Author information

1
    Department of Infectious Diseases, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China (mainland).
2
    Department of Digestive Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China (mainland).
3
    Hepatobiliary and Pancreatic Surgery Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China (mainland).

Abstract

BACKGROUND Depression and insomnia in chronic hepatitis B (CHB) patients affect the quality of life, disease diagnosis, and mortality. CHB patients are more likely to have psychological disorders, but the underlying mechanisms have not been elucidated. This study investigated the incidence of depression in patients with CHB and sought to identify risk factors for depression and insomnia in these patients, focusing on changes in liver function and thyroid hormone levels. MATERIAL AND METHODS This cross-sectional cohort study used the Hamilton Depression Scale and Athens Insomnia Scale to assess the depressive and insomnia states, respectively, of 209 CHB patients. Liver function, thyroid hormone levels, hepatitis B surface antigen, hepatitis B e-antigen, and hepatitis B virus-deoxyribonucleic acid load were evaluated. Liver cirrhosis was assessed by imaging (color Doppler ultrasound and computed tomography). A multivariate logistic regression model was used to analyze the correlation among various factors and depression and insomnia. RESULTS Subclinical and clinical depressive states were found in 23.9% and 5.3% and subclinical and clinical insomnia in 11% and 35.4% of patients, respectively. Depression and insomnia severity were significantly correlated with low FT3 (<3.5 mol/L). The odds ratios of low FT3 for subclinical and clinical depression and clinical insomnia were 3.07 (95% confidence interval (CI), 1.248-7.568), 7.85 (95% CI, 1.839-33.547), and 3.91 (95% CI, 1.417-10.789), respectively. CONCLUSIONS CHB patients are prone to depression and insomnia. FT3 reduction may be a risk factor for depression and insomnia. In clinical settings, more attention needs to be paid to the mental state of patients with FT3 reduction.

PMID:
    30973843
DOI:
    10.12659/MSM.914444

StephenW

Med Sci Monit。 2019年4月11日; 25：2672-2678。 doi：10.12659 / MSM.914444。
抑郁和失眠与慢性乙型肝炎的甲状腺激素水平密切相关。
Huang X1，Zhang H2，Qu C3，Liu Y1，Bian C1，Xu Y2。
作者信息

1
    青岛大学附属医院感染科，山东青岛（大陆）。
2
    青岛大学附属医院消化内科，山东青岛（大陆）。
3
    青岛大学附属医院肝胆胰外科中心，山东青岛（大陆）。

抽象

背景技术慢性乙型肝炎（CHB）患者的抑郁和失眠会影响生活质量，疾病诊断和死亡率。 CHB患者更可能患有心理障碍，但其潜在的机制尚未阐明。本研究调查了CHB患者抑郁的发生率，并寻求确定这些患者抑郁和失眠的危险因素，重点关注肝功能和甲状腺激素水平的变化。材料和方法这项横断面队列研究使用汉密尔顿抑郁量表和雅典失眠量表分别评估209名CHB患者的抑郁和失眠状态。评估肝功能，甲状腺激素水平，乙型肝炎表面抗原，乙型肝炎e抗原和乙型肝炎病毒 - 脱氧核糖核酸负荷。通过成像（彩色多普勒超声和计算机断层扫描）评估肝硬化。使用多变量逻辑回归模型分析各种因素与抑郁和失眠之间的相关性。结果亚临床和临床抑郁状态分别为23.9％和5.3％，亚临床和临床失眠分别为11％和35.4％。抑郁和失眠严重程度与低FT3（<3.5 mol / L）显着相关。亚临床和临床抑郁症和临床失眠的低FT3比值比为3.07（95％可信区间（CI），1.248-7.568），7.85（95％CI，1.839-33.547）和3.91（95％CI，1.417-分别为10.789）。结论CHB患者易患抑郁症和失眠症。 FT3减少可能是抑郁和失眠的危险因素。在临床环境中，需要更多地关注FT3减少患者的精神状态。

结论：
    30973843
DOI：
    10.12659 / MSM.914444