乙型肝炎病毒特异性效应CD8 + T细胞是疾病预后的重要决定因

StephenW

Vaccine. 2019 Mar 29. pii: S0264-410X(19)30392-5. doi: 10.1016/j.vaccine.2019.03.058. [Epub ahead of print]
Hepatitis B virus-specific effector CD8+ T cells are an important determinant of disease prognosis: A meta-analysis.
Zheng J1, Ou Z1, Xu Y1, Xia Z1, Lin X1, Jin S1, Liu Y1, Wu J2.
Author information

1
    Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
2
    Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China. Electronic address: [email protected].

Abstract
BACKGROUND:

Hepatitis B virus (HBV)-specific effector CD8+ T cells are critical for viral clearance. To determine the effects of HBV-specific effector CD8+ T cells on HBV infection, we performed a meta-analysis of the available literature.
METHODS:

Electronic database searches identified appropriately designed studies that detected specific CD8+ T cells in HBV-infected patients. Our main endpoints were the course of infection, seroconversion of HBV "e" antigen (HBeAg), the level of HBVDNA, and alanine aminotransferase (ALT) activity. We used a fixed/random model for analysis, according to the results of a heterogeneity test (P value of Q-squared, I2).
RESULTS:

Our searches found five eligible articles. Pooled estimation of the reported results showed that levels of specific CD8+ T cells were significantly higher in patients with acute hepatitis B than in patients with chronic hepatitis B (odds ratio [OR] = 76.30, 95% confidence interval [CI]: 15.37-378.70). With respect to chronic hepatitis B, patients with <107 copies/ml HBVDNA had higher levels of specific CD8+ T cells relative to patients with >107 copies/ml HBVDNA, but the difference had no statistics significance (OR: 3.89, 95% CI: 0.71-21.33). Patients with negative HBeAg or positive anti-HBeAg antibody (anti-HBe) results had significantly higher levels of specific CD8+ T cells versus patients with positive HBeAg results (OR: 5.82, 95% CI: 1.41-24.13). There were no significant associations between the levels of specific CD8+ T cells and serum ALT activity (OR = 0.86, 95% CI: 0.01-74.15).
CONCLUSION:

HBV-specific effector CD8+ T cells influence the disease activity in HBV-infected patients in various ways and determine prognosis by eliminating the virus. Therefore, efforts of studying HBV-specific effector CD8+ T cells focused vaccine are potentially needed.

Copyright © 2019 Elsevier Ltd. All rights reserved.
KEYWORDS:

Hepatitis B; Meta-analysis; Prognosis; Specific CD8(+) T cell

PMID:
    30935741
DOI:
    10.1016/j.vaccine.2019.03.058

StephenW

疫苗。 2019年3月29日.pii：S0264-410X（19）30392-5。 doi：10.1016 / j.vaccine.2019.03.058。 [印刷前的电子版]
乙型肝炎病毒特异性效应CD8 + T细胞是疾病预后的重要决定因素：荟萃分析。
郑J1，欧Z1，徐Y1，夏Z1，林X1，金S1，刘Y1，吴J2。
作者信息

1
温州医科大学附属第一医院消化内科，浙江温州325000
2
温州医科大学附属第一医院消化内科，浙江温州325000电子地址：[email protected]。

抽象
背景：

乙型肝炎病毒（HBV）特异性效应CD8 + T细胞对病毒清除至关重要。为了确定HBV特异性效应CD8 + T细胞对HBV感染的影响，我们对现有文献进行了荟萃分析。
方法：

我们的主要终点是感染过程，HBV“e”抗原血清转换（HBeAg），HBVDNA水平和丙氨酸氨基转移酶（ALT）根据异质性检验的结果，我们使用固定/随机模型进行分析（ Q值的P值，I2）。
结果：

我们的搜索找到了五篇符合条件汇总估计的报告结果显示，急性乙型肝炎患者特异性CD8 + T细胞水平显着高于慢性乙型肝炎患者（优势比[OR] = 76.30,95％可信区间[CI]：15.37-378.70 ）。就慢性乙型肝炎而言，相对于HBVDNA> 107拷贝/ ml的患者，<107拷贝/ ml HBVDNA患者的特异性CD8 + T细胞水平较高，但差异无统计学意义（OR：3.89,95％CI： 0.71-21.33）。 HBeAg阴性或抗-HBeAg阳性抗体（抗-HBe）结果的患者与HBeAg阳性结果相比，特异性CD8 + T细胞水平有所提高（OR：5.82,95％CI：1.41-24.13）。特异性CD8 + T细胞水平与血清​​ALT活性之间无显着相关性（OR = 0.86,95％CI：0.01-74.15）。
结论：

HBV特异性效应CD8 + T细胞以各种方式影响HBV感染患者的疾病活动，并通过消除病毒来确定预后。

版权所有©2019 Elsevier Ltd.保留所有权利。
关键词：

乙型肝炎; Meta分析;预后;特异性CD8（+）T细胞

结论：
30935741
DOI：
10.1016 / j.vaccine.2019.03.058