活化的γδT细胞在急性乙型肝炎患者中表现出细胞毒性和病

StephenW

Clin Immunol. 2019 Mar 23. pii: S1521-6616(18)30557-6. doi: 10.1016/j.clim.2019.03.005. [Epub ahead of print]
Activated γδ T cells exhibit cytotoxicity and the capacity for viral clearance in patients with acute hepatitis B.
Jia ZH1, Li YY2, Wang JY1, Zhang JY2, Huang A3, Guo XD4, Zhu ZY5, Wangx FS6, Wu XL7.
Author information

1
    State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
2
    Treatment and Research Center for Infectious Diseases, Beijing 302 Hospital, Beijing 100039, China.
3
    The Center for Non-infectious Liver Diseases, Beijing 302 Hospital, 100039, China.
4
    Department of Pathology, Beijing 302 Hospital, 100039, China.
5
    Hepatobiliary Surgery Center, Beijing 302 Hospital, 100039, China.
6
    Treatment and Research Center for Infectious Diseases, Beijing 302 Hospital, Beijing 100039, China. Electronic address: [email protected].
7
    School of Life Sciences, Tianjin University, Tianjin Engineering Center of Micro Nano Biomaterials and Detection Treatment Technology, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, China. Electronic address: [email protected].

Abstract

γδ T cells are a unique population of lymphocytes that have regulatory roles in patients with chronic hepatitis B (CHB); however, their role in acute hepatitis B (AHB) infection remains unclear. Phenotype and function of γδ T cells were analyzed in 29 AHB patients, 28 CHB patients, and 30 healthy controls (HCs) using immunofunctional assays. Compared with HCs and CHB patients, decreased peripheral and increased hepatic γδ T cells were found in AHB patients. Increased hepatic γδ T cells in AHB patients were attributed to elevated hepatic chemokine levels. Peripheral γδ T cells exhibited highly activated and terminally differentiated memory phenotype in AHB patients. Consistently, peripheral γδ T cells in AHB patients showed increased cytotoxic capacity and enhanced antiviral activity which was further proved in longitudinal study. Activated γδ T cells in AHB patients exhibited increased cytotoxicity and capacity for viral clearance associated with liver injury and the control of infection.

Copyright © 2019. Published by Elsevier Inc.
KEYWORDS:

Antiviral activity; Cytokine; Cytotoxity; Longitudinal study; γδ T cells

PMID:
    30914281
DOI:
    10.1016/j.clim.2019.03.005

StephenW

临床免疫。 2019年3月23日.pii：S1521-6616（18）30557-6。 doi：10.1016 / j.clim.2019.03.005。 [印刷前的电子版]
活化的γδT细胞在急性乙型肝炎患者中表现出细胞毒性和病毒清除能力。
Jia ZH1，Li YY2，Wang JY1，Zhang JY2，Huang A3，Guo XD4，Zhu ZY5，Wangx FS6，Wu XL7。
作者信息

1
    南开大学生命科学学院药物化学生物学国家重点实验室，天津300071
2
    北京302医院感染科治疗研究中心，北京100039
3
    北京302医院非传染性肝病中心，100039
4
    北京302医院病理科，100039
五
    北京302医院肝胆外科中心，100039
6
    北京302医院感染科治疗研究中心，北京100039电子地址：[email protected]。
7
    天津大学生命科学学院，天津市微纳生物材料与检测处理技术工程中心，化学科学与工程协同创新中心，天津300072电子地址：[email protected]。

抽象

γδT细胞是一种独特的淋巴细胞群，在慢性乙型肝炎（CHB）患者中具有调节作用;然而，它们在急性乙型肝炎（AHB）感染中的作用仍不清楚。使用免疫功能测定法在29名AHB患者，28名CHB患者和30名健康对照（HC）中分析γδT细胞的表型和功能。与HCs和CHB患者相比，在AHB患者中发现外周和肝脏γδT细胞减少。 AHB患者肝脏γδT细胞增加归因于肝脏趋化因子水平升高。外周γδT细胞在AHB患者中表现出高度活化和终末分化的记忆表型。一致地，AHB患者的外周γδT细胞显示出增加的细胞毒性能力和增强的抗病毒活性，这在纵向研究中得到进一步证实。 AHB患者中活化的γδT细胞表现出增加的细胞毒性和与肝损伤相关的病毒清除能力和感染控制。

版权所有©2019。Elsevier Inc.出版
关键词：

抗病毒活性;细胞因子;细胞毒性;纵向研究; γδT细胞

结论：
    30914281
DOI：
    10.1016 / j.clim.2019.03.005