乙型肝炎病毒的高环境稳定性和化学杀菌剂的灭活要求

StephenW

High Environmental Stability of Hepatitis B Virus and Inactivation Requirements for Chemical Biocides
Thoa Thi Than Eunji Jo Daniel Todt Phuong Hong Nguyen Jochen Steinmann Eike Steinmann Marc P Windisch
The Journal of Infectious Diseases, Volume 219, Issue 7, 15 March 2019, Pages 1044–1048, https://doi.org/10.1093/infdis/jiy620
Published:
24 October 2018
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Abstract

Hepatitis B virus (HBV) infection is considered a major public health problem worldwide, and a significant number of reports on nosocomial and occupational outbreaks have been reported. This systematic investigation of HBV stability and susceptibility to different antiseptics revealed that HBV infectivity was very stable, with a half-life of >22 days at 37°C. At 4°C, infectivity was barely reduced for up to 9 months. Different alcohols and commercially available hand antiseptics had a virucidal effect against HBV. We propose that very strict compliance with established hygienic guidelines should be mandatory to avoid and prevent HBV infections.
Biocides, infectivity, inactivation, hepatitis B virus, HepG2-NTCP, virion stability

StephenW

乙型肝炎病毒的高环境稳定性和化学杀菌剂的灭活要求
Thoa Thun Than Eunji Jo Daniel Todt Phuong Hong Nguyen Jochen Steinmann Eike Steinmann Marc P Windisch
Journal of Infectious Diseases，第219卷，第7期，2019年3月15日，第1044-1048页，https：//doi.org/10.1093/infdis/jiy620
发布时间：
2018年10月24日
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乙型肝炎病毒（HBV）感染被认为是世界范围内的主要公共卫生问题，并且已经报道了大量关于医院内和职业暴发的报告。这项对HBV稳定性和对不同防腐剂敏感性的系统研究表明，HBV感染性非常稳定，37°C时半衰期> 22天。在4°C时，传染性几乎不会降低，长达9个月。不同的醇和市售的手消毒剂具有抗HBV的杀病毒作用。我们建议严格遵守既定的卫生指南，以避免和预防HBV感染。
杀生物剂，感染性，灭活，乙型肝炎病毒，HepG2-NTCP，病毒体稳定性

StephenW

https://academic.oup.com/jid/article/219/7/1044/5144374