慢性乙型肝炎感染患者的死亡率：慢性肝炎队列研究（CHeCS）

StephenW

Mortality Among Patients With Chronic Hepatitis B Infection: The Chronic Hepatitis Cohort Study (CHeCS)
Danae Bixler Yuna Zhong Kathleen N Ly Anne C Moorman Philip R Spradling Eyasu H Teshale Loralee B Rupp Stuart C Gordon Joseph A Boscarino Mark A Schmidt ... Show more
Clinical Infectious Diseases, Volume 68, Issue 6, 5 March 2019, Pages 956–963, https://doi.org/10.1093/cid/ciy598
Published:
28 July 2018

Abstract
Background

According to death certificates, approximately 1800 persons die from hepatitis B annually in the United States; however, this figure may underestimate true mortality from chronic hepatitis B (CHB).
Methods

We analyzed data from CHB patients seen in the Chronic Hepatitis Cohort Study (CHeCS) between 1 January 2006 and 31 December 2013. We compared overall and cause-specific death rates and mean ages at death between CHeCS CHB decedents and U.S. decedents from the Multiple Cause of Death (MCOD) file.
Results

Of 4389 CHB patients followed for a mean of 5.38 years, 492 (11%) CHB patients died after a mean follow-up of 3.00 years. Compared to survivors, decedents were older, more likely to be White (40.6%), African-American (27.1%), or male (74.2%); and more likely to have had cirrhosis (59.8%), diabetes (27.2%), alcohol abuse (17.7%), hepatocellular carcinoma (17.5%), or a liver transplant (5.7%); whereas survivors were more likely to be Asian (48.8%; all P < .001). CHB patients died at an average age of 59.8 years—14 years younger than the general U.S. population—and at higher rates for all causes (relative risk [RR] = 1.85, 95% confidence interval [CI], 1.851–1.857) and liver-related causes (RR = 15.91, 95% CI, 15.81–16.01). Only 19% of CHB decedents and 40% of those dying of liver disease had hepatitis B reported on their death certificates.
Conclusions

Compared to the general population, CHB patients die at younger ages and higher rates from all causes and liver-related causes. Death certificates underrepresent the true mortality from CHB.

StephenW

慢性乙型肝炎感染患者的死亡率：慢性肝炎队列研究（CHeCS）
Danae Bixler Yuna Zhong Kathleen N Ly Anne C Moorman Philip R Spradling Eyasu H Teshale Loralee B Rupp Stuart C Gordon Joseph A Boscarino Mark A Schmidt ...显示更多
临床传染病，第68卷，第6期，2019年3月5日，第956-963页，https：//doi.org/10.1093/cid/ciy598
发布时间：
2018年7月28日

抽象
背景

根据死亡证明，美国每年约有1800人死于乙型肝炎;然而，这个数字可能低估了慢性乙型肝炎（CHB）的真实死亡率。
方法

我们分析了2006年1月1日至2013年12月31日在慢性肝炎队列研究（CHeCS）中观察到的CHB患者的数据。我们比较了CHeCS CHB死者和美国死因之间死因的总体和原因特异性死亡率以及平均死亡年龄of Death（MCOD）文件。
结果

在4389例CHB患者中平均随访5.38年，492例（11％）CHB患者在平均随访3。00年后死亡。与幸存者相比，死者年龄较大，更可能是白人（40.6％），非洲裔美国人（27.1％）或男性（74.2％）;更有可能患有肝硬化（59.8％），糖尿病（27.2％），酒精滥用（17.7％），肝细胞癌（17.5％）或肝移植（5.7％）;幸存者更可能是亚洲人（48.8％;所有P <.001）。 CHB患者的平均年龄为59.8岁 - 比美国一般人群年轻14岁 - 所有原因的死亡率较高（相对风险[RR] = 1.85,95％置信区间[CI]，1.851-1.857）和肝脏相关原因（RR = 15.91,95％CI，15.81-16.01）。只有19％的CHB死者和40％死于肝病的人在他们的死亡证明上报告了乙型肝炎。
结论

与一般人群相比，CHB患者死于所有原因和肝脏相关原因的年龄较小和较高的比率。死亡证明不足以代表CHB的真正死亡率。

StephenW

https://academic.oup.com/cid/article/68/6/956/5061152?rss=1