母体HBV DNA与脐带血HBV DNA的适度联系

StephenW

February 26, 2019
Moderate Link Between Maternal HBV DNA and Cord Blood HBV DNA


For mothers with chronic hepatitis B virus (HBV), there is a moderate correlation between maternal HBV DNA and cord blood HBV DNA, according to results published in Pediatrics and Neonatology.

However, the results did not indicate that cord blood HBV DNA was linked with an increased rate of vertical transmission.

The study included mother-and-child pairs in which the mother had chronic HBV infection (n=92). Mothers underwent antenatal screening for hepatitis B surface antigen, hepatitis B e antigen (HBeAg), and HIV antibodies. The researchers used real-time polymerase chain reaction to test maternal and cord blood for HBV DNA. They administered standard immunoprophylaxis with both active and passive immunization to the infants. When each infant reached 9 months of age, he or she underwent serologic testing.

The researchers found a moderate positive correlation between maternal HBV DNA and cord blood HBV DNA (r2=.521, P <.001).

The results indicated that mothers who were positive for HBeAg were more likely to be younger, to have higher HBV viral load, and to have higher cord viremia compared with mothers who were negative for HBeAg.

At 9 months of age, serologic testing showed that 1 infant was infected with HBV. This infant’s mother was positive for HBeAg; no infants of mothers who were negative for HBeAg were infected.

The researchers found that infants delivered by mothers who were HBeAg positive and those who had high HBV DNA (>6 LOG IU/mL) had an increased relative risk for cord blood viremia (1.48 and 1.62, respectively).
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“This study showed that the levels of umbilical cord HBV DNA increased with maternal HBV DNA in the third trimester and correlated to the maternal HBeAg positivity,” the researchers wrote.

Reference

Lee LY, Lee GH, Mattar C, Saw S, Aw M. Maternal HBeAg positivity and viremia associated with umbilical cord blood hepatitis B viremia [published online January 5, 2019]. Pediatr Neonatol. doi:10.1016/j.pedneo.2019.01.002

StephenW

2019年2月26日
母体HBV DNA与脐带血HBV DNA的适度联系


根据Pediatrics and Neonatology发表的结果，对于患有慢性乙型肝炎病毒（HBV）的母亲，母体HBV DNA与脐带血HBV DNA之间存在中度相关性。

然而，结果并未表明脐带血HBV DNA与垂直传播率增加有关。

该研究包括母亲和儿童对，其中母亲患有慢性HBV感染（n = 92）。母亲接受了乙肝表面抗原，乙型肝炎e抗原（HBeAg）和HIV抗体的产前筛查。研究人员使用实时聚合酶链反应来测试母体和脐带血中的HBV DNA。他们对婴儿进行标准免疫预防，同时进行主动和被动免疫。当每个婴儿达到9个月大时，他或她接受了血清学检测。

研究人员发现母体HBV DNA与脐带血HBV DNA呈中度正相关（r2 = .521，P <.001）。

结果表明，与HBeAg阴性的母亲相比，HBeAg阳性的母亲更可能更年轻，具有更高的HBV病毒载量，并且具有更高的脐带血症。

在9个月大时，血清学检测显示1名婴儿感染了HBV。这名婴儿的母亲对HBeAg呈阳性反应;没有感染HBeAg阴性的母亲的婴儿被感染。

研究人员发现，HBeAg阳性母亲和HBV DNA高（> 6 LOG IU / mL）的母亲分娩的婴儿脐带血性病毒血症的相对风险增加（分别为1.48和1.62）。
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研究人员写道：“这项研究表明，脐带HBV DNA水平在妊娠晚期随着母体HBV DNA的增加而增加，并与母体HBeAg阳性相关。”

参考

Lee LY，Lee GH，Mattar C，Saw S，Aw M.母亲HBeAg阳性和与脐带血乙型肝炎病毒血症相关的病毒血症[2019年1月5日在线发表]。 Pediatr Neonatol。 DOI：10.1016 / j.pedneo.2019.01.002