慢性HBV感染可降低发生血脂异常的风险

StephenW

Virginia Schad, PharmD
December 04, 2018
Chronic HBV Infection May Lower the Risk for Developing Dyslipidemia


Chronic hepatitis B virus infection may actually lower the risk for developing dyslipidemia. Chronic hepatitis B virus infection may actually lower the risk for developing dyslipidemia.

Chronic hepatitis B virus (HBV) infection may lower the risk for developing dyslipidemia, according to large cohort study findings published in the Journal of Viral Hepatitis.1

In patients with HBV infection, there is increasing evidence that demonstrates the presence of metabolic derangements, especially in lipid profiles, suggesting that there is an association between HBV infection and host metabolism.2 Further, clinical studies have demonstrated an inverse relationship between HBV infection and lipid profiles.3-6 However, no longitudinal studies have evaluated this association in patients who did not have baseline dyslipidemia. Therefore, researchers in Korea investigated the association between HBV infection and the incidence of new-onset dyslipidemia in 62,287 healthy adults with no history of cirrhosis, a normal baseline lipid profile, and hepatitis B surface antigen (HBsAg) seropositivity.1


They found that there were 12,331 incident cases of hypercholesterolemia during 278,004.4 person-years of follow-up. The adjusted hazard ratio for incident hypercholesterolemia, high low-density lipoprotein (LDL) cholesterolemia, hypertriglyceridemia, high non-high-density lipoprotein (HDL) cholesterolemia, and low HDL cholesterolemia comparing HBsAg-positive- with HBsAg-negative-participants were 0.71, 0.83, 0.61, 0.69, and 1.10, respectively. An inverse association between HBsAg positivity and incident high apolipoprotein B (apoB) was also identified with a corresponding 0.63 hazard ratio, but HBsAg positivity was associated with a higher incidence of low apolipoprotein A (apoA).

“In conclusion, in a cohort study of non-cirrhotic and non-diabetic adults, we demonstrated that HBsAg positivity was associated with decreased risk of hypercholesterolemia, high LDL cholesterolemia, high non-HDL cholesterolemia, hypertriglyceridemia and high apoB, but increased risk of low apoA, indicating that HBV has a lowering effect on lipid profiles” noted the investigators.1


References

    Joo E-J, Chang Y, Yeom J-S, Cho YK, Ryu S. Chronic hepatitis B virus infection and risk of dyslipidaemia: A cohort study [published online September 29, 2018] J Viral Hepat. doi:10.1111/jvh.13014

StephenW

Virginia Schad，PharmD
2018年12月4日
慢性HBV感染可降低发生血脂异常的风险


慢性乙型肝炎病毒感染实际上可能降低发生血脂异常的风险。慢性乙型肝炎病毒感染实际上可能降低发生血脂异常的风险。

根据发表在“病毒性肝炎杂志”上的大型队列研究结果，慢性乙型肝炎病毒（HBV）感染可降低患上血脂异常的风险。

在HBV感染患者中，越来越多的证据表明存在代谢紊乱，特别是在脂质谱中，表明HBV感染与宿主代谢之间存在关联.2此外，临床研究表明HBV感染与HBV感染之间呈负相关关系。然而，没有纵向研究评估了没有基线血脂异常的患者的这种相关性。因此，韩国研究人员调查了62,287名没有肝硬化病史，正常基线血脂谱和乙型肝炎表面抗原（HBsAg）血清阳性的健康成人HBV感染与新发血脂异常的发生率之间的关系。


他们发现在278,004.4人年的随访期间发生了12,331例高胆固醇血症事件。事件高胆固醇血症，高低密度脂蛋白（LDL）胆固醇血症，高甘油三酯血症，高非高密度脂蛋白（HDL）胆固醇血症和低HBL胆固醇血症比较HBsAg阳性与HBsAg阴性参与者的调整风险比为0.71，分别为0.83,0.61,0.69和1.10。 HBsAg阳性与事件高载脂蛋白B（apoB）之间的反向关联也被确定，相应的0.63风险比，但HBsAg阳性与低载脂蛋白A（apoA）的较高发生率相关。

“总之，在一项非肝硬化和非糖尿病成人的队列研究中，我们证明HBsAg阳性与高胆固醇血症，高LDL胆固醇血症，高非HDL胆固醇血症，高甘油三酯血症和高apoB风险降低相关，但风险增加研究者指出，低apoA，表明HBV对脂质谱具有降低作用


参考

    Joo E-J，Chang Y，Yeom J-S，Cho YK，Ryu S.慢性乙型肝炎病毒感染和血脂异常的风险：一项队列研究[在线发表于2018年9月29日] J病毒Hepat。 DOI：10.1111 / jvh.13014