脐带血中阳性或阴性母体乙型肝炎e抗原（HBeAg）婴儿的抗体

StephenW

Hum Vaccin Immunother. 2019 Feb 8. doi: 10.1080/21645515.2019.1575712. [Epub ahead of print]
Comparison of antibody response to hepatitis B vaccination in infants with positive or negative maternal hepatitis B e antigen (HBeAg) in cord blood: implication for the role of HBeAg as an immunotolerogen.
Zhou YH1, Huang H1, Ning M1, Liu J1, Chen J2, Feng J2, Dai Y2, Hu Y1,3.
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Abstract

Hepatitis B e antigen (HBeAg) has been considered to cause immunotolerance to hepatitis B virus (HBV) in newborn infants after fetal HBeAg exposure. This study compared anti-HBs responses to hepatitis B vaccination in infants who were born to HBeAg-positive and -negative mothers respectively, to investigate whether fetal HBeAg exposure may induce immunotolerance to HBV. Totally 265 infants who received recommended neonatal immunoprophylaxis against hepatitis B and had no HBV infection were included. Anti-HBs levels were compared between 124 infants with cord blood positive HBeAg and 141 infants with cord blood negative HBeAg at 7-12 months of age. The infants in two groups had similar age at the follow-up (10.0 ± 2.3 vs 10.1 ± 2.3 months, P = 0.590). Overall, 259 (97.7%) of 265 infants achieved anti-HBs levels (mIU/ml) ≥10 and 6 (2.3%) others had anti-HBs <10. Of 124 HBeAg-positive infants at birth, 46.0%, 39.5%, 12.1%, and 2.4% had anti-HBs levels (mIU/ml) ≥1000, 100-999.9, 10-99.9, and <10, respectively. Of 141 HBeAg-negative infants at birth, 35.5%, 48.9%, 13.5%, and 2.1% showed ≥1000, 100-999.9, 10-99.9, and <10, respectively. The proportions of each anti-HBs level between the two groups were comparable (all P > 0.05). Additionally, the distribution of anti-HBs response levels were also comparable in infants with high and low HBeAg levels (P = 0.818). In conclusions, the fetal HBeAg exposure does not inhibit the antibody response to neonatal hepatitis B vaccination. The data suggest that HBeAg appears not inducing immunotolerance to HBV.
KEYWORDS:

HBeAg; Hepatitis B vaccination; anti-HBs response; fetal exposure

PMID:
    30735449
DOI:
    10.1080/21645515.2019.1575712

StephenW

Hum Vaccin Immunother。 2019年2月8日。土井：10.1080 / 21645515.2019.1575712。 [印刷前的电子版]
脐带血中阳性或阴性母体乙型肝炎e抗原（HBeAg）婴儿的抗体对乙型肝炎疫苗接种的反应比较：暗示HBeAg作为免疫原的作用。
Zhou YH1，Huang H1，Ning M1，Liu J1，Chen J2，Feng J2，Dai Y2，Hu Y1,3。
作者信息
抽象

已经认为乙型肝炎e抗原（HBeAg）在胎儿HBeAg暴露后对新生儿的乙型肝炎病毒（HBV）产生免疫耐受。该研究比较分别出生于HBeAg阳性和阴性母亲的婴儿的抗HBs应答与乙型肝炎疫苗接种，以调查胎儿HBeAg暴露是否可能诱导HBV免疫耐受。共纳入265名婴儿，他们接受了针对乙型肝炎的推荐新生儿免疫预防并且没有HBV感染。比较了124名脐带血阳性HBeAg婴儿和141名脐带血HBeAg阴性的婴儿在7-12个月时的抗-HBs水平。两组婴儿在随访时年龄相近（10.0±2.3 vs 10.1±2.3个月，P = 0.590）。总体而言，265名婴儿中有259名（97.7％）的抗-HBs水平（mIU / ml）≥10，其他6名（2.3％）的抗-HBs <10。在出生的124名HBeAg阳性婴儿中，46.0％，39.5％，12.1％和2.4％的抗-HBs水平（mIU / ml）分别≥1000,100-999.9,10-99.9和<10。在出生的141名HBeAg阴性婴儿中，35.5％，48.9％，13.5％和2.1％分别显示≥1000,100-999.9,10-99.9和<10。两组之间每种抗-HBs水平的比例是可比较的（所有P> 0.05）。此外，HBeAg水平高和低的婴儿的抗HBs反应水平分布也相当（P = 0.818）。总之，胎儿HBeAg暴露不会抑制抗体对新生儿乙型肝炎疫苗接种的反应。数据表明HBeAg似乎不诱导对HBV的免疫耐受。
关键词：

大三阳;乙型肝炎疫苗接种;抗HBs反应;胎儿暴露

结论：
    30735449
DOI：
    10.1080 / 21645515.2019.1575712