几丁质酶-3样蛋白1，天冬氨酸氨基转移酶 - 血小板比值指数

StephenW

Comparison of chitinase-3-like protein 1, aspartate aminotransferase-to-platelet ratio index, and fibrosis-4 index with shear-wave elastography

Mushtaq, Saadiyaa; Ghani, Eijaza; Azam, Khalidb; Hussain, Tabindaa
European Journal of Gastroenterology & Hepatology: March 2019 - Volume 31 - Issue 3 - p 357–362
doi: 10.1097/MEG.0000000000001291
Original Articles: Hepatology

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Background In the past, there has been an exponential increase in the potential biomarkers that can be used for staging of liver fibrosis. In light of intraobserver and intralobular variations, criticism has been directed at liver biopsy, and its efficacy has been challenged. Shear-wave elastography (SWE) has become a routine method for pre-assessment of liver fibrosis. Serum markers such as chitinase-3-like protein 1 (CHI3L1) also known as YKL-40, aspartate aminotransferase-to-platelet ratio index, and fibrosis-4 (Fib-4) index have been researched as potential alternates to detect liver fibrosis.

Study A total of 150 enrolled patients with chronic hepatitis underwent serum analysis to estimate CHI3L1 or YKL-40 level, aspartate aminotransferase-to-platelet ratio index, and Fib-4 index. These patients also underwent SWE.

Results The distribution of fibrosis grade according to SWE was F0: 46 patients, F1: 31 patients, F2: 16 patients, F3: four patients, and F4: 53 patients. Receiver operating characteristic curve analysis for F0–F1 versus F2–F3, F0–F1 versus F4, and F2–F3 versus F4 gave area under curve values of 0.56 (P>0.05), 0.76 (P<0.01), and 0.75, respectively (P<0.01) for aspartate aminotransferase-to-platelet ratio index; of 0.65 (P<0.05), 0.78 (P<0.01), and 0.7, respectively (P<0.05) for Fib-4 index; and 0.98, 0.99, and 0.95, respectively (P<0.01 for all) for CHI3L1.

Conclusion CHI3L1 could be used as a preliminary tool to assess mild/absent fibrosis from significant fibrosis and cirrhosis.

StephenW

几丁质酶-3样蛋白1，天冬氨酸氨基转移酶 - 血小板比值指数和纤维化-4指数与剪切波弹性成像的比较

Mushtaq，Saadiyaa; Ghani，Eijaza;阿扎姆，哈立德;塔宾达，侯赛因
欧洲胃肠病学和肝病学杂志：2019年3月 - 第31卷 - 第3期 - 第357-362页
doi：10.1097 / MEG.0000000000001291
原创文章：肝脏病学

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背景技术过去，可用于肝纤维化分期的潜在生物标志物呈指数增长。鉴于观察者和小叶内变异，批评已针对肝脏活组织检查，其疗效受到挑战。剪切波弹性成像（SWE）已成为预先评估肝纤维化的常规方法。血清标志物如几丁质酶-3样蛋白1（CHI3L1）也被称为YKL-40，天冬氨酸氨基转移酶 - 血小板比率指数和纤维化-4（Fib-4）指数已被研究作为检测肝纤维化的潜在替代品。

研究共对150名入组慢性肝炎患者进行血清分析，以评估CHI3L1或YKL-40水平，天冬氨酸氨基转移酶与血小板比值指数和Fib-4指数。这些患者也接受了SWE。

结果根据SWE的纤维化程度分布为F0：46例患者，F1：31例患者，F2：16例患者，F3：4例患者，F4：53例患者。 F0-F1与F2-F3，F0-F1与F4和F2-F3与F4的接收器操作特征曲线分析得到曲线下面积分别为0.56（P> 0.05），0.76（P <0.01）和0.75。天冬氨酸氨基转移酶与血小板比值指数（P <0.01）; Fib-4指数分别为0.65（P <0.05），0.78（P <0.01）和0.7（P <0.05）; CHI3L1分别为0.98,0.99和0.95（全部P <0.01）。

结论CHI3L1可作为评估显着纤维化和肝硬化轻度/无纤维化的初步工具。