中国研究人员开发了用于乙型肝炎研究的双人源小鼠

StephenW

ECNS Wire
Chinese researchers develop dual-humanized mice for hepatitis B study

2019-02-01 16:09:08Ecns.cn Editor : Mo Hong'e

(ECNS) - Researchers from Xiamen University and Zhejiang University have developed the world's first model mice to accurately delineate the natural history of hepatitis B virus (HBV) infection and immune-pathophysiology, the development of disease as affected by the immune system.

Teams led by Professor Xia Ningshao of Xiamen University and Li Jun at the First Affiliated Hospital at Zhejiang University spent five years in reaching the breakthrough, publishing their results in the journal Gut.

The model of HBV-induced chronic hepatitis and cirrhosis in mice using the transplant of human bone marrow mesenchymal stem cells will help clarify mechanisms of host-virus interactions and identify intervention strategies for HBV-related liver diseases.

Dual-humanized mice were sensitive to chronic HBV infection, generated sustained human immune and inflammatory responses and ultimately developed liver cirrhosis, according to the paper.

An estimated 250 million people across the world are living with the hepatitis B virus, including 80 million in China. About 600,000 die from HBV-related liver disease each year globally.

StephenW

ECNS电线
中国研究人员开发了用于乙型肝炎研究的双人源小鼠

2019-02-01 16：09：08Ecns.cn编辑：莫红娥

（ECNS） - 来自厦门大学和浙江大学的研究人员开发出世界上第一台模型小鼠，以准确描绘乙型肝炎病毒（HBV）感染和免疫病理生理学的自然史，以及受免疫系统影响的疾病的发展。

由厦门大学夏宁韶教授和浙江大学第一附属医院李军领导的团队花了五年时间才取得突破，在Gut杂志上发表了他们的成果。

使用人骨髓间充质干细胞移植的小鼠HBV诱导的慢性肝炎和肝硬化模型将有助于阐明宿主 - 病毒相互作用的机制，并确定HBV相关肝病的干预策略。

根据该论文，双人源小鼠对慢性HBV感染敏感，产生持续的人体免疫和炎症反应，并最终发展为肝硬化。

据估计，全世界有2.5亿人患有乙型肝炎病毒，其中包括中国的8000万人。全球每年约有600,000人死于与HBV相关的肝病。