乙型肝炎病毒感染与慢性肾病的关系：中国农村地区300万20至

StephenW

Medicine (Baltimore). 2019 Feb;98(5):e14262. doi: 10.1097/MD.0000000000014262.
Association between hepatitis B virus infection and chronic kidney disease: A cross-sectional study from 3 million population aged 20 to 49 years in rural China.
Du Y1,2, Zhang S3, Hu M2,4,5, Wang Q3, Liu N2,4,5, Shen H3, Zhang Y3, Yan D3, Zhang M2,4,5.
Author information

1
    Department of Nephrology, Beijing Shijitan Hospital, Capital Medical University.
2
    Beijing Key Laboratory of Urinary Cellular Molecular Diagnostics.
3
    Department of Maternal and Child Health, National Health and Family Planning Commission of the People s Republic of China.
4
    Clinical Laboratory Medicine, Beijing Shijitan Hospital, Capital Medical University.
5
    Clinical Laboratory Medicine, Peking University Ninth School of Clinical Medicine, Beijing, China.

Abstract

Hepatitis B virus (HBV) infection can lead to different types of chronic kidney diseases (CKD) in clinical practice. However, HBV infection has been observed to have no significant association with CKD indicators in some epidemiological surveys. This research aims to estimate CKD prevalence in HBV infection population and clarify the relationship between HBV infection status and CKD.The participants aged 20 to 49 years were selected by multistage random sampling from January 1, 2010 to December 31, 2012 across 31 provinces and regions in rural China. The data was collected by standard questionnaire and physical check-up. Status of HBV infection was diagnosed as immune tolerant phase, hepatitis B envelope antigen -positive chronic HBV infection, inactive HBV carrier, hepatitis B envelope antigen -negative chronic HBV infection and resolved HBV infection based on serological markers, and the level of hepatic function, respectively.In total, 2,969,502 subjects were included in the study. In population aged 20 to 49 years in rural China, prevalence of HBV infection was 12.17%. Prevalence of proteinuria, hematuria, estimated glomerular filtration rate less than 60 mL/min/1.73m and CKD was 0.94%(95% CI = 0.91-0.97%) vs. 0.65%(95% CI = 0.64-0.66%), 1.92%(95% CI = 1.87-1.96%) vs. 1.19% (95% CI = 1.18-1.21%), 1.02%(95% CI = 0.99-1.06%) vs. 0.77% (95% CI = 0.76-0.78%), and 3.85%(95% CI = 3.78-3.91%) vs. 2.60%(95% CI = 2.58-2.62%) in population with HBV infection and without infection, respectively. Prevalence of CKD and indicators was higher in population in every status of HBV infection than in population without infection, respectively (all P < 0·0001). Every HBV infection status was a risk factor for CKD.CKD prevalence was higher in population in every status of HBV infection than without infection. HBV infection was a risk factor for CKD in population aged 20 to 49 years in rural China.

PMID:
    30702585
DOI:
    10.1097/MD.0000000000014262

StephenW

医学（巴尔的摩）。 2019年2月; 98（5）：e14262。 doi：10.1097 / MD.0000000000014262。
乙型肝炎病毒感染与慢性肾病的关系：中国农村地区300万20至49岁人群的横断面研究。
Du Y1,2，Zhang S3，Hu M2,4,5，Wang Q3，Liu N2,4,5，Shen H3，Zhang Y3，Yan D3，Zhang M2,4,5。
作者信息

1
    首都医科大学附属北京世纪坛医院肾内科。
2
    北京市细胞分子诊断重点实验室。
3
    中华人民共和国国家卫生和计划生育委员会妇幼保健司。
4
    首都医科大学附属北京世纪潭医院临床检验医学。
五
    北京大学第九临床医学院临床检验医学研究所，北京

抽象

在临床实践中，乙型肝炎病毒（HBV）感染可导致不同类型的慢性肾病（CKD）。然而，在一些流行病学调查中，观察到HBV感染与CKD指标没有显着关联。本研究旨在评估HBV感染人群中CKD患病率，明确HBV感染状况与CKD之间的关系。2010年1月1日至2012年12月31日期间，对31个省和地区的20~49岁参与者进行多阶段随机抽样选择。在中国农村。通过标准问卷和身体检查收集数据。 HBV感染状况被诊断为免疫耐受期，乙型肝炎包膜抗原阳性慢性HBV感染，无活性HBV携带者，乙型肝炎包膜抗原 - 阴性慢性HBV感染，基于血清学标志物解决HBV感染，以及肝功能水平，总共有2,969,502名受试者被纳入研究。在中国农村20至49岁人口中，HBV感染率为12.17％。蛋白尿，血尿的患病率，估计肾小球滤过率小于60 mL / min / 1.73m，CKD为0.94％（95％CI = 0.91-0.97％），而0.65％（95％CI = 0.64-0.66％），1.92 ％（95％CI = 1.87-1.96％）与1.19％（95％CI = 1.18-1.21％），1.02％（95％CI = 0.99-1.06％）对比0.77％（95％CI = 0.76-0.78）在HBV感染和无感染的人群中分别为％）和3.85％（95％CI = 3.78-3.91％）与2.60％（95％CI = 2.58-2.62％）。 HBV感染的人群中CKD和指标的患病率分别高于无感染人群（均P <0.0001）。每个HBV感染状态都是CKD的危险因素。在HBV感染的每个状态中，CKD患病率均高于无感染患者。 HBV感染是中国农村20至49岁人群CKD的危险因素。

结论：
    30702585
DOI：
    10.1097 / MD.0000000000014262