母亲HBeAg阳性和与脐带血乙型肝炎病毒血症相关的病毒血症。

StephenW

Pediatr Neonatol. 2019 Jan 5. pii: S1875-9572(18)30508-4. doi: 10.1016/j.pedneo.2019.01.002. [Epub ahead of print]
Maternal HBeAg positivity and viremia associated with umbilical cord blood hepatitis B viremia.
Lee LY1, Lee GH2, Mattar C3, Saw S4, Aw M5.
Author information

1
    Department of Neonatology, National University Hospital, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: [email protected].
2
    Department of Medicine, National University Hospital, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
3
    Department of Obstetrics and Gynaecology, National University Hospital, Singapore; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
4
    Department of Laboratory Medicine, National University Hospital, Singapore.
5
    Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore.

Abstract
BACKGROUND:

Hepatitis B (HBV) transmission may result from in utero transmission. We aimed to determine the correlation between maternal serum and umbilical cord blood HBV DNA levels in infants delivered by chronic HBV-infected mothers and to describe the effect of cord blood viremia on vertical transmission.
METHODS:

A prospective cohort of 92 chronic HBV-infected mother-and-child pairs recruited over three years was analyzed. Maternal and cord blood were tested for HBV DNA by real-time PCR. Standard immunoprophylaxis with both active and passive immunization was administered to all infants. Serological testing was performed on all infants at 9 months of age.
RESULTS:

Moderate positive correlation of the maternal HBV DNA with cord blood HBV DNA was demonstrated (r2 = 0.521, p = <0.001). HBeAg +ve mothers were younger with higher HBV and cord viremia. At 9 months of age, one infant was infected. Infants delivered by HBeAg positive mothers and mothers with high HBV DNA of more than 6 LOG IU/mL (1 x 106 IU/mL) have increased relative risk of cord blood viremia.
CONCLUSIONS:

Maternal HBV DNA and presence of HBeAg were positively correlated to cord blood HBV DNA in infants delivered by chronic HBV-infected mothers. Our data suggest that reducing maternal viremia during the antenatal period may help to reduce cord blood viremia.

Copyright © 2019. Published by Elsevier B.V.
KEYWORDS:

cord blood hepatitis B viral (HBV) DNA; hepatitis B core antibody; in-utero exposure to HBV; maternal hepatitis B viral (HBV) DNA

PMID:
    30683599
DOI:
    10.1016/j.pedneo.2019.01.002

StephenW

Pediatr Neonatol。 2019年1月5日.pii：S1875-9572（18）30508-4。 doi：10.1016 / j.pedneo.2019.01.002。 [印刷前的电子版]
母亲HBeAg阳性和与脐带血乙型肝炎病毒血症相关的病毒血症。
Lee LY1，Lee GH2，Mattar C3，Saw S4，Aw M5。
作者信息

1
    新加坡国立大学医院新生儿科;新加坡国立大学Yong Loo Lin医学院儿科。电子地址：[email protected]。
2
    新加坡国立大学医院医学系;新加坡国立大学Yong Loo Lin医学院医学系。
3
    新加坡国立大学医院妇产科;新加坡国立大学Yong Loo Lin医学院妇产科。
4
    新加坡国立大学医院检验医学系。
五
    新加坡国立大学Yong Loo Lin医学院儿科，新加坡; Khoo Teck Puat-国立大学儿童医学研究所，国立大学卫生系统，新加坡。

抽象
背景：

乙型肝炎（HBV）传播可能来自子宫内传播。我们的目的是确定慢性HBV感染母亲分娩的婴儿的母体血清和脐带血HBV DNA水平之间的相关性，并描述脐带血性病毒血症对垂直传播的影响。
方法：

分析了一项前瞻性队列研究，其中包括三年内招募的92名慢性HBV感染的母婴配对。通过实时PCR测试母体和脐带血的HBV DNA。对所有婴儿施用标准的免疫预防，包括主动和被动免疫。对9个月大的所有婴儿进行血清学检测。
结果：

证实了母体HBV DNA与脐带血HBV DNA的中度正相关（r2 = 0.521，p = <0.001）。 HBeAg + ve母亲更年轻，HBV和脐带血症更高。在9个月大时，一名婴儿被感染。 HBeAg阳性母亲和HBV DNA高于6 LOG IU / mL（1 x 106 IU / mL）的母亲分娩的婴儿脐带血性病毒血症的相对风险增加。
结论：

母体HBV DNA和HBeAg的存在与慢性HBV感染母亲分娩的婴儿脐带血HBV DNA呈正相关。我们的数据表明，在产前期减少母体病毒血症可能有助于减少脐带血病毒血症。

版权所有©2019。Elsevier B.V.
关键词：

脐血乙型肝炎病毒（HBV）DNA;乙型肝炎核心抗体;子宫内暴露于HBV;母体乙型肝炎病毒（HBV）DNA

结论：
    30683599
DOI：
    10.1016 / j.pedneo.2019.01.002