6最近关于肝癌风险的报告，减少几率的选择

StephenW

6 recent reports on liver cancer risks, options to reduce odds
January 21, 2019

As cancer rates continue to rise throughout the U.S. and internationally, researchers have focused on defining factors and demographics correlated with a higher risk for hepatocellular carcinoma and extrahepatic liver cancer to guide clinical practice.

Healio Gastroenterology and Liver Disease presents the following reports on studies that revealed risk factors for liver cancer including incident diabetes and fatty liver, while an alternative diet and regular vigorous exercise reduced the risk for liver cancer.

Adherence to ‘Healthy Eating Index’ diet may reduce liver cancer risk

Adherence to the Alternative Healthy Eating Index-2010 dietary pattern may reduce the risk for hepatocellular carcinoma, according to a study published in Hepatology.

“Diets are complex combinations of nutrients and other compounds that act synergistically within individual foods and across food combinations, thus, evaluating the association of dietary pattern with health outcomes may capture dietary effects on health more completely,” Xuehong Zhang, MD, from Massachusetts General Hospital, and colleagues wrote. Read more

Regular vigorous exercise reduces liver cancer risk

Regular vigorous physical activity reduced the risk for hepatocellular carcinoma by approximately 45%, according to recently published data.

“The distribution of HCC varies greatly according to geographic location and it is more common in low- and middle-income countries than in developed countries,” Sebastian E. Baumeister, PhD, from the University of Greifswald in Germany, and colleagues wrote. “The recent increase in HCC incidence is thought to be caused by increases in obesity, diabetes, and physical inactivity.” Read more

Incident diabetes increases risk for liver cancer, hepatic diseases

Diabetes and high blood glucose levels among individuals without known diabetes correlated with increased risks for liver cancer and chronic liver disease, according results of a Chinese cohort study.

“The increase in diabetes prevalence is so recent [in China] that its impact on risk of liver cancer and liver diseases, if any, may not yet have fully emerged,” Yuanjie Pang, from the University of Oxford in the United Kingdom, and colleagues wrote. “Our finding linking diabetes with liver cancer was broadly consistent with those of previous prospective studies in Western and other East Asian populations.” Read more



Oncimmune expands access to cancer risk lung, liver blood tests

Oncimmune Holdings entered into an agreement with America’s Choice Provider Network to expand access to the company’s EarlyCDT-Lung and EarlyCDT-Liver blood tests, designed to assess cancer risks, according to a press release.

“Our collaboration with America’s Choice Provider Network is one of several payor and provider agreements we have recently finalized to ensure as many people as possible in the U.S. are able to use our EarlyCDT tests to facilitate earlier diagnoses,” Marco Casarin, general manager of Oncimmune, said in the release. Read more

Extrahepatic cancer risk increases after HCV SVR

Extrahepatic cancer was more common in patients with hepatitis C and was the leading cause of death in patients who achieved sustained virologic response compared with the general population, according to results of a French cohort study.

“A sustained viral response (SVR) in HCV patients and maintained viral suppression (MVR) by nucleos(t)ide analogues in HBV patients have changed the clinical course of viral cirrhosis during recent decades,” Manon Allaire, MD, from the Hospital Center University of Caen Normandie in France, and colleagues wrote. “Our results suggest a role for viral replication in the carcinogenesis of lymphoproliferative disorders, although the mechanism by which HCV may cause hematological malignancies remains unclear.” Read more

Fatty liver imposes 91% higher risk for cancer

Patients with non-alcoholic fatty liver disease carried a 91% higher risk for malignancy and the risk for cancer with obesity is “driven by NAFLD,” according to a presentation at The Liver Meeting 2018.

“The risk of malignancy was higher in NAFLD vs. controls ... 91% higher than the general population when we take all cancers into account,” Alina M. Allen, MD, of Mayo Clinic, Rochester, Minn., said during her presentation. “Obesity is associated with a higher risk of cancer only in those with NAFLD and not in those without.” Read more

StephenW

6最近关于肝癌风险的报告，减少几率的选择
2019年1月21日

随着美国和国际癌症发病率持续上升，研究人员一直致力于确定与肝细胞癌和肝外肝癌风险较高相关的因素和人口统计学，以指导临床实践。

Healio Gastroenterology and Liver Disease提供以下报告，揭示肝癌的风险因素，包括糖尿病和脂肪肝，而替代饮食和定期剧烈运动可降低患肝癌的风险。

坚持“健康饮食指数”饮食可以降低肝癌风险

根据肝病学杂志发表的一项研究，坚持替代健康饮食指数-2010饮食模式可能会降低患肝细胞癌的风险。

“饮食是营养素和其他化合物的复杂组合，在个体食物和食物组合中协同作用，因此，评估饮食模式与健康结果的关联可以更完全地捕捉饮食对健康的影响，”来自马萨诸塞州的医学博士张学红医院和同事写道。阅读更多

定期剧烈运动可降低肝癌风险

根据最近公布的数据，定期剧烈的体力活动可将肝细胞癌的风险降低约45％。

“HCC的分布根据地理位置的不同而有很大差异，在低收入和中等收入国家比在发达国家更为常见，”来自德国格赖夫斯瓦尔德大学的Sebastian E. Baumeister博士及其同事写道。 “最近HCC发病率的增加被认为是由肥胖，糖尿病和缺乏身体活动的增加引起的。”阅读更多内容

糖尿病事件增加了肝癌，肝病的风险

根据一项中国队列研究结果显示，未知糖尿病患者的糖尿病和高血糖水平与肝癌和慢性肝病风险增加有关。

“在中国，糖尿病患病率的增加是如此近以至于它对肝癌和肝病风险的影响（如果有的话）可能尚未完全出现，”英国牛津大学的袁杰杰和同事写道。 “我们将糖尿病与肝癌联系起来的研究结果与之前在西方和其他东亚人群中进行的前瞻性研究大体一致。”阅读更多



Oncimmune扩大了癌症风险，肝脏血液检测的可及性

据新闻报道，Oncimmune Holdings与美国的选择供应商网络达成协议，扩大公司的EarlyCDT-Lung和EarlyCDT-Liver血液检测，旨在评估癌症风险。

“我们与美国选择提供商网络的合作是我们最近确定的几个付款人和提供商协议之一，以确保尽可能多的美国人能够使用我们的EarlyCDT测试来促进早期诊断，”Oncimmune总经理Marco Casarin ，在发布中说。阅读更多

HCV SVR后肝外癌风险增加

根据一项法国队列研究的结果，肝外癌在丙型肝炎患者中更为常见，并且与一般人群相比，是获得持续病毒学应答的患者的主要死亡原因。

“近几十年来，HCV患者的持续病毒应答（SVR）和HBV患者的核苷（酸）类似物维持病毒抑制（MVR）改变了病毒性肝硬化的临床过程，”医学中心医学博士Manon Allaire法国卡昂诺曼底大学及其同事写道。 “我们的研究结果表明病毒复制在淋巴增生性疾病的发生中起作用，尽管HCV可能导致血液系统恶性肿瘤的机制仍不清楚。”阅读更多

脂肪肝使癌症风险增加91％

根据2018年肝脏会议上的一篇报道，患有非酒精性脂肪性肝病的患者患恶性肿瘤的风险高出91％，而肥胖导致的癌症风险“由NAFLD驱动”。

“当我们考虑所有癌症时，NAFLD与对照组相比，恶性肿瘤的风险更高......比普通人群高出91％，”明尼苏达州罗切斯特市梅奥诊所的医学博士Alina M. Allen说。介绍。 “只有NAFLD患者才会出现更高的癌症风险，而没有NAFLD的患者则更高。”阅读更多内容