通过瞬时弹性成像降低肝硬度表明慢性乙型肝炎患者的肝细

StephenW

Medicine (Baltimore). 2019 Jan;98(3):e13929. doi: 10.1097/MD.0000000000013929.
Decreased liver stiffness by transient elastography indicates lower incidence of hepatocellular carcinoma in patients with chronic hepatitis B.
Zhang Y1, Wang C2, Li H3, Ding Y2.
Author information

1
    Department of Ultrasonography.
2
    Department of Gastroenterology, Jining No 1 People's Hospital, Jining, Shandong.
3
    Department of Liver and Gallbladder Surgery, Heze Municiple Hospital, Heze, Shandong, China.

Abstract

The prognositc value of dynamic liver stiffness (LS) variation on hepatocellular carcinoma (HCC) incidence in patients with chronic hepatitis B (CHB) remains to be explored. We aim to compare HCC incidence in patients with compensated CHB-related cirrhosis with increased and decreased LS after nucleos(t)ide analog (NA) regimens.A total of 168 patients with CHB-related compensated cirrhosis were divided into groups according to LS variation post to NA treatment. The laboratory results of 2 groups were reviewed and investigated. The probability of HCC development among each group was analyzed and compared.A total of 168 patients with CHB with compensated cirrhosis received NA treatment and Fibroscan. Child-Pugh score, alanine aminotransferase, total bilirubin level, status of hepatitis B e antigen, and serum hepatitis B virus DNA level were compared between groups. The cumulative probability of HCC development in patients with decreased LS was significantly lower than in patients with increased LS (P < .05). Multi-variant analysis indicated that decreased LS was significantly associated with lower probability of HCC development (hazard ratio, 0.65; 95% confidence interval range, 0.33-0.84, P < .05).Decreased LS after NA treatment indicates a lower HCC incidence in patients with CHB with compensated cirrhosis.

PMID:
    30653099
DOI:
    10.1097/MD.0000000000013929

StephenW

医学（巴尔的摩）。 2019年1月; 98（3）：e13929。 doi：10.1097 / MD.0000000000013929。
通过瞬时弹性成像降低肝硬度表明慢性乙型肝炎患者的肝细胞癌发病率较低。
Zhang Y1，Wang C2，Li H3，Ding Y2。
作者信息

1
    超声检查科。
2
    济宁市第一人民医院消化科，山东济宁
3
    山东省菏泽市菏泽市医院肝胆外科

抽象

慢性乙型肝炎（CHB）患者肝细胞癌（HCC）发病率动态肝硬度（LS）变化的预后值仍有待探索。我们的目的是比较核心（t）ide类似物（NA）方案后CHB相关性代偿性肝硬化患者的HCC发生率与LS增加和减少的情况。根据LS变异将168例CHB相关代偿性肝硬化患者分组。发给NA治疗。对2组实验室结果进行了回顾和研究。分析比较各组HCC发生概率。共168例CHB合并代偿性肝硬化患者接受NA治疗和Fibroscan治疗。比较组间Child-Pugh评分，丙氨酸氨基转移酶，总胆红素水平，乙型肝炎e抗原状态和血清乙型肝炎病毒DNA水平。 LS降低患者HCC发生的累积概率显着低于LS升高患者（P <.05）。多变量分析表明，LS降低与HCC发展概率降低显着相关（风险比，0.65; 95％置信区间范围，0.33-0.84，P <.05）.Na治疗后LS降低表明HCC发病率较低。患有CHB并伴有代偿性肝硬化的患者。

结论：
    30653099
DOI：
    10.1097 / MD.0000000000013929